Technology-Dev-Core

技术-开发-核心

• 批准号: 10699304
• 负责人: SALLY Maureen MCFALL
• 金额: $ 118.49万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2023-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10699304
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Africa South of the Sahara; African; Anti-Retroviral Agents; Area; Award; Biological Assay; Biomedical Engineering; Businesses; Calibration; Caring; Cellular Phone; Clinical; Collaborations; Detection; Developing Countries; Development; Devices; Diagnostic; Diagnostic Errors; Diagnostic tests; Dust; Electricity; Electronic Medical Records and Genomics Network; Environmental Risk Factor; Fostering; Funding; Funding Opportunities; Goals; Grant; HIV; HIV diagnosis; HIV drug resistance; Hepatitis B; Hepatitis C; Home; Humidity; Image; Immunoassay; Incidence; Incubated; Infrastructure; Institutes; Lighting; Maintenance; Medical; Mentorship; Mission; Molecular; Monitor; National Institute of Biomedical Imaging and Bioengineering; Nigeria; Output; Pathway interactions; Patients; Performance; Persons; Pharmaceutical Preparations; Point of Care Technology; Procedures; Process; Rapid diagnostics; Reduce health disparities; Refrigeration; Research; Research Personnel; Resource-limited setting; Services; South Africa; Strategic Planning; Structure; Technology; Temperature; Testing; Time; Training; Tuberculosis; United Nations; United States National Institutes of Health; Universities; Validation; Viral; Visual; Water Supply; base; clinical practice; commercialization; community setting; comorbidity; cost; design; improved; innovation; low and middle-income countries; non-tuberculosis mycobacteria; operation; performance tests; point of care; point-of-care diagnostics; programs; prototype; recruit; research clinical testing; screening; skills training; synthetic biology; technology development; underserved community; usability; user-friendly

Summary Technology Development (Tech Dev) Core The Technology Development Core of the Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN) will support the development of vital POC technology specifically designed for patient management of people living with HIV in low and middle income countries with emphasis on the diagnostic needs in sub-Saharan Africa. We will support technology projects specifically designed for low resource settings with low or limited medical infrastructure such as restricted access to electricity, refrigeration and/or central water supply. A successful test will be user friendly, requiring only local training in its operation and maintenance, manufacturable at low cost with low cost consumables, rapid result, durable, contain internal checks of device/assay performance, self-calibration and error diagnosis. Projects supported by C-THAN will conform to high priority topics of HIV/AIDS research, be amenable to the conditions of low resource environments, and have high likelihood of commercialization in developing countries. A unique feature of C- THAN is our commitment to fostering local technology development in LMICs by providing specific funding opportunities for home-grown solutions via coordinated efforts to specifically incubate POC technology for HIV care in LMICs. This goal is supported by our access to a network of emerging African biomedical engineering programs through our partners in Nigeria and South Africa. We will build a robust pipeline of POC technology by identifying diagnostic needs, recruiting projects that meet those needs, monitoring progress made in funded projects, providing services and mentorship to guide projects to maturity, and facilitating the transfer of projects for clinical evaluation. The output will be a pipeline of products of high clinical impact developed from a well- balanced research portfolio originating from the Technology Development Core.

摘要技术开发（技术开发）核心 艾滋病毒/艾滋病的技术发展中心的技术开发核心 西北大学（Than）将支持专门设计的重要POC技术的开发 用于低收入和中等收入国家中艾滋病毒携带者的患者管理，重点是 撒哈拉以南非洲的诊断需求。我们将支持专门为低低设计的技术项目 具有低或有限的医疗基础设施的资源设置，例如限制电力，制冷 和/或中央供水。成功的测试将是用户友好的，仅需要本地培训 和维护，可以低成本制造，低成本消耗品，快速效果，耐用，内部包含内部 检查设备/测定性能，自我校准和错误诊断。 C-c-Than Will的项目 符合艾滋病毒/艾滋病研究的高优先级主题，适合低资源条件 环境，并且在发展中国家有很高的商业化。 C-的独特功能 而不是我们通过提供特定资金来促进LMIC的本地技术开发的承诺 通过协调的努力，为艾滋病毒培养POC技术的协调努力提供了本土解决方案的机会 LMICS的护理。我们进入新兴的非洲生物医学工程网络为此目标提供了支持 通过我们在尼日利亚和南非的合作伙伴的计划。我们将建立强大的POC技术管道 通过确定诊断需求，招募满足这些需求的项目，监视资助的进度 项目，提供服务和指导，指导项目到期和促进项目的转移 用于临床评估。该输出将是由高临床影响产物的管道。 平衡的研究组合源自技术开发核心。