The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN)

西北大学艾滋病毒/艾滋病护理点技术创新中心 (C-THAN)

• 批准号: 9973111
• 负责人: SALLY Maureen MCFALL
• 金额: $ 151.96万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-11 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9973111
• 关键词: AIDS clinical trial group; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adoption; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Award; Bedside Testings; Biological Assay; Biomedical Engineering; Car Phone; Care Technology Points; Caring; Clinical; Clinical Management; Clinical Research; Collaborations; Collection; Communicable Diseases; Communication; Communities; Cutaneous Tuberculosis; Detection; Development; Devices; Diagnostic; Diagnostic tests; Disease; Engineering; Ensure; Evaluation; Foundations; Future; Goals; HIV; HIV diagnosis; HIV drug resistance; HIV/HCV; Health; Health Professional; Health Technology; Hepatitis B; Hepatitis C; Hepatitis C Antigens; Human immunodeficiency virus test; Hypersensitivity skin testing; Incidence; Individual; Industrialization; Infection; Institution; Journals; Knowledge; Laboratories; Longevity; Maintenance; Mali; Mission; Monitor; National Institute of Biomedical Imaging and Bioengineering; Needs Assessment; Nigeria; Nigerian; Output; Pathway interactions; Patients; Pharmaceutical Preparations; Physicians; Prevention; Process; Production; Readiness; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Scientist; South Africa; Sputum; Structure; Tanzania; Techniques; Technology; Testing; Textbooks; Training; Training Programs; Translating; Translational Research; Translations; Tuberculosis; United Nations; United States National Institutes of Health; Universities; Validation; Viral; Work; Writing; base; clinical application; clinical translation; commercialization; community setting; comorbidity; design; experience; global health; health disparity; improved; innovation; low and middle-income countries; mycobacterial; non-tuberculosis mycobacteria; point of care; point-of-care diagnostics; programs; prototype; research clinical testing; screening; skills; technology development; training opportunity; training project

Summary Overall The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C- THAN) will develop a pipeline of needs-based point-of-care technologies critical for improved management of HIV/AIDS infected individuals in low-and-middle-income countries (LMICs). C-THAN will harness our existing expertise and our research and clinical network which has a 17-year history of dynamic and productive collaboration on addressing infectious diseases in sub-Saharan Africa. Northwestern University is joined by the Universities of Lagos, Ibadan and Jos (Nigeria), Cape Town and Stellenbosch (South Africa), University of Sciences, Techniques and Technologies Bamako (Mali) and Muhimbili University of Health and Allied Sciences (Tanzania). The United Nations' Program on HIV and AIDS (UNAIDS) has set the ambitious 90-90-90 goals to achieve detection of 90% of HIV cases, treatment for 90% of those cases, and viral suppression for 90% of those treated, by 2020. This will not be achieved in LMICs without improvement of the current diagnostic pathway with POC diagnostic tests that are affordable, rapid, easy to use, and require little maintenance. C-THAN will serve as a platform for the support of research projects to develop POC technologies that address this unmet need across multiple levels of technology readiness which are amenable to the conditions of the developing world. Projects supported will range from needs assessment to commercialization, with a view to ensuring translation into clinical impact. Our overall goal is to support the development of POC technologies to promote high priority topics of NIH HIV/AIDS research, including: Reducing HIV incidence by improving screening, detection and treatment monitoring related to HIV, HIV drug resistance, and antiretroviral drug levels; Diagnosing HIV-associated comorbidities which include tuberculosis (TB), non-tuberculosis mycobacteria (NTM), hepatitis B (HBV), and hepatitis C (HCV); Reducing health disparities by developing testing technology that can function in underserved community settings; and Training of the workforce able to translate POC technologies from Reseach & Development to implementation. The C-THAN structure will incorporate clinical and user needs in project development while providing expertise and resources to address early barriers to commercialization and implementation. Its Core components will operate in an integrated manner to deliver a scope of work entailing: 1) assessment of unmet clinical needs in POC testing for HIV/AIDS and its comorbidities; 2) collaboration with relevant scientists, physicians, researchers and engineers; 3) development of essential technical, clinical, industrial and regulatory partnerships; 4) clinical testing of prototype POC devices in the field; and 5) creation of training opportunities for technology developers, evaluators, and other stakeholders. C-THAN will have major impact on the prevention and clinical management of HIV/AIDS in LMICs and globally, and will lay a knowledge foundation to sustain POC technology development beyond its lifespan. 1

总结 总体 西北大学艾滋病毒/艾滋病护理点技术创新中心 (C- THAN）将开发一系列基于需求的护理点技术，这对于改善患者的管理至关重要 低收入和中等收入国家 (LMIC) 的艾滋病毒/艾滋病感染者。 C-THAN 将利用我们现有的 专业知识以及我们的研究和临床网络，该网络拥有 17 年充满活力和富有成效的历史 合作应对撒哈拉以南非洲的传染病。西北大学加入 拉各斯大学、伊巴丹大学和乔斯大学（尼日利亚）、开普敦大学和斯泰伦博斯大学（南非）、 科学、技术和工艺巴马科（马里）和穆辛比利健康与相关科学大学 （坦桑尼亚）。 联合国艾滋病规划署 (UNAIDS) 制定了雄心勃勃的 90-90-90 目标，以实现 检测 90% 的艾滋病毒病例，治疗 90% 的病例，抑制 90% 的病毒 到 2020 年，如果不改进当前的诊断途径，中低收入国家就无法实现这一目标 POC 诊断测试经济实惠、快速、易于使用且几乎不需要维护。 C-THAN 将作为支持研究项目的平台来开发 POC 技术，以解决 这种未满足的需求跨越了多个级别的技术准备情况，这些级别适合于条件 发展中国家。支持的项目范围从需求评估到商业化，以期 确保转化为临床影响。我们的总体目标是支持 POC 技术的发展 促进 NIH HIV/AIDS 研究的高度优先主题，包括： 与艾滋病毒、艾滋病毒耐药性和抗逆转录病毒药物相关的筛查、检测和治疗监测 级别；诊断 HIV 相关合并症，包括结核病 (TB)、非结核病 分枝杆菌 (NTM)、乙型肝炎 (HBV) 和丙型肝炎 (HCV)；通过发展减少健康差距 测试可在服务匮乏的社区环境中发挥作用的技术；对劳动力进行培训，使其能够 将 POC 技术从研究和开发转化为实施。 C-THAN 结构将在项目开发中纳入临床和用户需求，同时提供专业知识 以及解决商业化和实施的早期障碍的资源。其核心组件将 以综合方式开展工作，包括：1) 评估未满足的临床需求 HIV/艾滋病及其合并症的 POC 检测； 2）与相关科学家、医生合作， 研究人员和工程师； 3) 基本技术、临床、工业和监管的发展 伙伴关系； 4）原型POC设备的现场临床测试； 5) 创造培训机会 对于技术开发人员、评估人员和其他利益相关者。 C-THAN将对 中低收入国家和全球艾滋病毒/艾滋病的预防和临床管理，并将为以下方面奠定知识基础： 在其生命周期之外维持 POC 技术的发展。 1