The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN)

西北大学艾滋病毒/艾滋病护理点技术创新中心 (C-THAN)

• 批准号: 9623833
• 负责人: SALLY Maureen MCFALL
• 金额: $ 151.58万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-11 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9623833
• 关键词: AIDS clinical trial group; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adoption; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Award; Bedside Testings; Biological Assay; Biomedical Engineering; Car Phone; Care Technology Points; Caring; Clinical; Clinical Management; Clinical Research; Collaborations; Collection; Communicable Diseases; Communication; Communities; Comorbidity; Cutaneous Tuberculosis; Detection; Development; Devices; Diagnostic; Diagnostic tests; Disease; Engineering; Ensure; Evaluation; Foundations; Future; Goals; HIV; HIV diagnosis; HIV drug resistance; HIV/HCV; Health; Health Professional; Healthcare; Hepatitis B; Hepatitis C; Hepatitis C Antigens; Human immunodeficiency virus test; Hypersensitivity skin testing; Incidence; Individual; Industrialization; Infection; Institution; Journals; Knowledge; Laboratories; Longevity; Maintenance; Mali; Mission; Monitor; National Institute of Biomedical Imaging and Bioengineering; Needs Assessment; Nigeria; Nigerian; Output; Pathway interactions; Patients; Pharmaceutical Preparations; Physicians; Prevention; Process; Production; Readiness; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Scientist; South Africa; Sputum; Structure; Tanzania; Techniques; Technology; Testing; Textbooks; Training; Training Programs; Translating; Translational Research; Translations; Tuberculosis; United Nations; United States National Institutes of Health; Universities; Validation; Viral; Work; Writing; base; clinical application; clinical translation; commercialization; community setting; design; experience; global health; health disparity; improved; innovation; low and middle-income countries; mycobacterial; non-tuberculosis mycobacteria; point of care; point-of-care diagnostics; programs; prototype; research clinical testing; screening; skills; technology development; training opportunity; training project

Summary Overall The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C- THAN) will develop a pipeline of needs-based point-of-care technologies critical for improved management of HIV/AIDS infected individuals in low-and-middle-income countries (LMICs). C-THAN will harness our existing expertise and our research and clinical network which has a 17-year history of dynamic and productive collaboration on addressing infectious diseases in sub-Saharan Africa. Northwestern University is joined by the Universities of Lagos, Ibadan and Jos (Nigeria), Cape Town and Stellenbosch (South Africa), University of Sciences, Techniques and Technologies Bamako (Mali) and Muhimbili University of Health and Allied Sciences (Tanzania). The United Nations' Program on HIV and AIDS (UNAIDS) has set the ambitious 90-90-90 goals to achieve detection of 90% of HIV cases, treatment for 90% of those cases, and viral suppression for 90% of those treated, by 2020. This will not be achieved in LMICs without improvement of the current diagnostic pathway with POC diagnostic tests that are affordable, rapid, easy to use, and require little maintenance. C-THAN will serve as a platform for the support of research projects to develop POC technologies that address this unmet need across multiple levels of technology readiness which are amenable to the conditions of the developing world. Projects supported will range from needs assessment to commercialization, with a view to ensuring translation into clinical impact. Our overall goal is to support the development of POC technologies to promote high priority topics of NIH HIV/AIDS research, including: Reducing HIV incidence by improving screening, detection and treatment monitoring related to HIV, HIV drug resistance, and antiretroviral drug levels; Diagnosing HIV-associated comorbidities which include tuberculosis (TB), non-tuberculosis mycobacteria (NTM), hepatitis B (HBV), and hepatitis C (HCV); Reducing health disparities by developing testing technology that can function in underserved community settings; and Training of the workforce able to translate POC technologies from Reseach & Development to implementation. The C-THAN structure will incorporate clinical and user needs in project development while providing expertise and resources to address early barriers to commercialization and implementation. Its Core components will operate in an integrated manner to deliver a scope of work entailing: 1) assessment of unmet clinical needs in POC testing for HIV/AIDS and its comorbidities; 2) collaboration with relevant scientists, physicians, researchers and engineers; 3) development of essential technical, clinical, industrial and regulatory partnerships; 4) clinical testing of prototype POC devices in the field; and 5) creation of training opportunities for technology developers, evaluators, and other stakeholders. C-THAN will have major impact on the prevention and clinical management of HIV/AIDS in LMICs and globally, and will lay a knowledge foundation to sustain POC technology development beyond its lifespan. 1

总结总结 西北大学艾滋病毒/艾滋病的工艺创新中心（C-） 而不是）将开发一条基于需求的基于需求的护理技术，这对于改善管理至关重要 艾滋病毒/艾滋病感染中低收入国家（LMIC）的人。 c-比人将利用我们的现有 专业知识以及我们的研究和临床网络具有17年的动态和生产史 解决撒哈拉以南非洲传染病的合作。西北大学加入了 拉各斯，伊巴丹和乔斯大学，开普敦和斯特伦博斯（南非），大学 科学，技术和技术Bamako（Mali）和Muhimbili卫生大学和联盟科学 （坦桑尼亚）。 联合国艾滋病毒和艾滋病计划（UNAIDS）设定了雄心勃勃的90-90-90目标 检测90％的艾滋病毒病例，其中90％的病例治疗，其中90％的病毒抑制 到2020年处理。 带有负担得起，快速，易于使用且几乎不需要维护的POC诊断测试。 C-Twan将作为支持研究项目的平台，以开发POC技术来解决 在多个技术准备就绪的情况下，这种未满足的需求适合于 发展中国家。支持的项目将从需求评估到商业化，以期 确保转化为临床影响。我们的总体目标是支持POC技术的发展 促进NIH艾滋病毒/艾滋病研究的高优先级主题，包括：通过改善降低艾滋病毒的发病率 与HIV，HIV耐药性和抗逆转录病毒药物有关的筛查，检测和治疗监测 水平；诊断与HIV相关的合并症，包括结核病（TB），无结核病 分枝杆菌（NTM），丙型肝炎（HBV）和丙型肝炎（HCV）；通过发展来减少健康差异 测试可以在服务不足的社区环境中起作用的技术；和劳动力的培训 将POC技术从研究与开发转换为实施。 C-by结构将在项目开发中纳入临床和用户需求，同时提供专业知识 以及解决商业化和实施障碍的资源。它的核心组件将 以综合方式运作以提供需要的工作范围：1）评估未满足的临床需求 POC测试艾滋病毒/艾滋病及其合并症； 2）与相关科学家，医生合作， 研究人员和工程师； 3）开发基本技术，临床，工业和监管 伙伴关系； 4）该场原型POC设备的临床测试； 5）创造培训机会 对于技术开发人员，评估人员和其他利益相关者。 C-比人对 在LMIC和全球的艾滋病毒/艾滋病的预防和临床管理，并将为知识基础奠定 维持超越其寿命的POC技术开发。 1