Tanzania AIDS Malignancies Training and Research International Program (TAMTRP)

坦桑尼亚艾滋病恶性肿瘤培训和研究国际计划 (TAMTRP)

• 批准号: 10650673
• 负责人: Julius David Mwaiselage
• 金额: $ 10万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650673
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; Area; Caring; Characteristics; Clinic; Clinical; Community Healthcare; Data; Documentation; Failure; Future; HIV; Health; Health Personnel; Healthcare; Institutes; International; Investigation; Kaposi Sarcoma; Lead; Malignant Neoplasms; Mentors; Oceans; Oncologist; Outcome; Outcome Measure; Patients; Pattern; Reporting; Research; Research Personnel; Survival Rate; Talents; Tanzania; Testing; Training; Treatment outcome; career; cohort; data quality; design; follow-up; implementation research; improved; programs; research study; skills; sociodemographics; treatment response

PROJECT SUMMARY/ABSTRACT Despite the highest Kaposi’s sarcoma (KS) burden in the world, treatment outcome data is scarce in sub- Saharan Africa (SSA), making meaningful comparisons of SSA with other regions difficult. The 5-year survival rate of HIV-associated KS is reportedly as low as 9%. Failure to keep PLWH closely connected to healthcare beyond ART leads to loss of follow-up that contributes to poor treatment response and outcomes. Reports in SSA have documented up to 40% loss to follow-up leading to poor data quality and making outcome measures unfeasible. Lack of proper documentation of sociodemographic, clinicopathological characteristics, and objective assessment of treatment responses and outcomes have led to the limited interpretation of outcomes in SSA. Currently, ORCI attends ~120 KS patients annually, however, it is evident that there is a limited linkage between HIV and KS care leading to the scattering of important clinical and outcome information. Therefore, there is a need to develop, test, and implement strategies to enhance the linkages and outcomes. This need is further compounded by a lack of well- trained researchers in HIV-associated cancers to address this area of need. We are proposing to mentor a junior oncologist who can lead a study in establishing a clinical cohort of KS patients at Ocean Road Cancer Institute (ORCI) in Tanzania, and test whether the engagement of the HIV care and treatment clinic (CTC) and community healthcare workers enhance follow-ups of KS patients and improve data on KS treatment response and outcomes. We have now identified a talented junior oncologist who is committed to a clinical and operational research career in HIV-associated cancers to lead the proposed study. We hypothesize that surrounding KS patients with a clinical team that maintains contact and answers questions will enable the investigation of short- and long-term outcomes in KS treatment and will help define barriers against and facilitators of connection to care. To test this hypothesis, the project team will: a) determine socio-demographic and clinical characteristics of a cohort of Kaposi’s sarcoma patients at ORCI, b) determine the treatment patterns and outcomes of Kaposi’s Sarcoma patients in relation to sociodemographic and clinical characteristics, and c) evaluate barriers and facilitators of retention in care for KS patients attending ORCI. The proposed supplement project is significant as it provides a unique opportunity for a new investigator to acquire new skills in HIV clinical, operational, and implementation research as a stepping-stone to embark on HIV/AIDS research career and improve research capacity in Tanzania. Moreover, the study will provide outcomes and barriers information for future HIV research studies, and for designing strategies to improve the health outcomes of PLWH in Tanzania and beyond.

项目摘要/摘要 尽管世界上卡波西最高的肉瘤（KS）燃烧，但治疗结果数据很少。 撒哈拉非洲（SSA），使SSA与其他地区进行有意义的比较。 5年 据报道，与HIV相关的KS的存活率低至9％。无法保持PLWH紧密连接 超越艺术的医疗保健导致失去随访，导致治疗反应不良和 结果。 SSA的报告记录了多达40％的损失，导致数据质量差，并且 做出不可行的结果措施。缺乏适当的社会人口统计学记录， 临床病理学特征以及治疗反应和结果的客观评估 导致对SSA结果的有限解释。目前，Orci每年参加约120 KS患者， 但是，有证据表明，艾滋病毒和KS护理之间存在有限的联系，导致散射 重要的临床和结果信息。因此，需要开发，测试和实施 增强联系和结果的策略。由于缺乏良好的良好，这种需求进一步加剧了 训练有素的研究人员与HIV相关的癌症中的研究人员解决了这一需求。我们建议指导 初级肿瘤科医生可以领导一项研究，以在海洋路建立KS患者的临床队列 坦桑尼亚的癌症研究所（ORCI），并测试艾滋病毒护理和治疗诊所的参与 （CTC）和社区医疗保健工作者增强了KS患者的随访，并改善了KS的数据 治疗反应和结果。我们现在已经确定了一位才华横溢的初级肿瘤学家，他致力于 艾滋病毒相关癌症领域的临床和运营研究职业领导拟议的研究。我们 假设周围的KS患者与临床团队保持联系并回答问题 将使短期和长期成果在KS治疗中投资，并有助于定义障碍 反对和促进护理的联系。为了检验该假设，项目团队将：a）确定 Orci的Kaposi肉瘤患者队列的社会人口统计学和临床​​特征，b） 确定Kaposi肉瘤患者的治疗模式和结果 社会人口统计学和临床​​特征，c）评估障碍和保留率的促进者 对于参加ORCI的KS患者。拟议的补充项目很重要，因为它提供了独特的 新研究者获得艾滋病毒临床，操作和实施方面的新技能的机会 研究是踏入艾滋病毒/艾滋病研究职业并提高研究能力的垫脚石 坦桑尼亚。此外，该研究将为未来的艾滋病毒研究提供结果和障碍信息 研究，以及设计策略以改善坦桑尼亚及其他地区的PLWH的健康状况。