AIDS Malignancies Training and Research International Program (AMTRIP)

艾滋病恶性肿瘤培训和研究国际计划 (AMTRIP)

• 批准号: 10405562
• 负责人: Chipepo Kankasa
• 金额: $ 29.17万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405562
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Behavioral; Bioinformatics; Cancer Biology; Cancer Research Infrastructure; Chronic; Clinical; Collaborations; Country; Diagnosis; Disease; Doctor of Philosophy; Educational workshop; Epidemic; Future; Genomics; Graduate Degree; HIV-1; Health Personnel; Health Professional; Hospitals; Human Resources; Immunosuppression; Individual; Infrastructure; Institution; Instruction; International; Laboratories; Lead; Leadership; Longevity; Malignant Neoplasms; Mentorship; Molecular; Nebraska; Outcome; Persons; Population; Research; Research Methodology; Research Personnel; Role; Teaching Hospitals; Techniques; Training; Universities; Zambia; anticancer research; antiretroviral therapy; design; doctoral student; experience; hospital laboratories; laboratory facility; medical schools; molecular pathology; next generation; prevent; programs; recruit; success

PROJECT SUMMARY/ABSTRACT HIV/AIDS is at epidemic proportions in Zambia, where approximately 1.2 million people – representing about 12% of the country's adult population – are infected. Concomitant with this epidemic, the widespread availability of free anti-retroviral treatment in-country has increased the lifespan of HIV-1 infected individuals, resulting in prolonged chronic immunosuppression and increased occurrence of HIV-associated cancers. However, in-country efforts to prevent, diagnose, and manage cancer in Zambia have been hindered by a lack of laboratory facilities, insufficient cancer research infrastructure, and a shortage of trained personnel. Recognizing these critical gaps, the University of Zambia School of Medicine, the University Teaching Hospitals, and the University of Nebraska-Lincoln leveraged the success of a previous Fogarty partnership to establish the AIDS Malignancies Training and Research International Program (AMTRIP) in collaboration with a new lead partner, the Cancer Diseases Hospital (CDH). This unique program aims to enhance Zambia's cancer research infrastructure and capacity by training Zambian biomedical researchers and health care providers in laboratory techniques and research methodology related to basic cancer biology, molecular genomics, and bioinformatics. Now in its fifth year, AMTRIP has made significant strides by providing intensive long-term graduate degree training and short- and medium-term technical training for a diverse group of 25 trainees; hosting workshops for over 300 health care professionals; successfully transitioning trainees into mentorship roles; adapting program activities to meet the needs of trainees and the rapidly changing cancer research landscape; and leveraging partnerships with other D43 programs to expand the program's impact. Building on these accomplishments, this renewal application seeks to further enhance cancer research capacity in Zambia by: 1) continuing to provide long-term academic instruction and research experiences for eight current master's and three current PhD students in Zambia and recruiting four additional master's and two additional PhD students; 2) providing medium-term (six months to one year) technical training for trainees in topics related to molecular pathology, cancer biology, bioinformatics and genomics; and 3) delivering short- term training (less than three months) and technical workshops (3-5 days) designed to enhance basic, clinical, implementation, genomics, bioinformatics, and behavioral cancer research in collaboration with other regional partners and programs. Expected outcomes of this renewal include the graduation of eight current master's and three current PhD candidates; recruitment and training of an additional four master's and two PhD students in relevant cancer research fields; the transition of trainees into mentorship roles; enhanced infrastructure at Zambian institutions, including the completion of a CDH laboratory renovation; and expanded partnerships with other D43 programs. Given current progress and anticipated renewal outcomes, AMTRIP is on track to transition program leadership to the next generation of cancer researchers in a future renewal.

项目摘要/摘要 艾滋病毒/艾滋病处于赞比亚的流行比例，约有120万人代表 该国成人人口的12％被感染。与这种流行病相关的宽度 自由抗逆转录病毒治疗的可用性增加了HIV-1感染个体的寿命， 导致长期慢性免疫抑制和HIV相关癌症的发生增加。 然而，在赞比亚，国内努力预防，诊断和管理癌症已受到缺乏的阻碍 实验室，癌症研究基础设施不足以及训练有素的人员短缺。 认识到这些关键差距，赞比亚大学医学院，大学教学 医院，内布拉斯加州林肯大学利用了以前的Fogarty合作伙伴关系的成功 与与 新的主要伴侣癌症疾病医院（CDH）。这个独特的计划旨在增强赞比亚的 癌症研究基础设施和能力通过培训赞比亚生物医学研究人员和医疗保健 与基本癌症生物学有关的实验室技术和研究方法的提供者，分子 基因组学和生物信息学。现在已经是第五年了，Amtrip通过提供密集的方式取得了长足的进步 长期研究生学位培训和25人的潜水员组的短期和中期技术培训 学员；为300多名医疗保健专业人员举办讲习班；成功将学员过渡到 精明的角色；适应计划活动以满足培训的需求和快速变化的癌症 研究格局；并利用与其他D43计划的合作伙伴关系来扩大该计划的影响。 在这些成就的基础上，该更新应用程序旨在进一步增强癌症研究 赞比亚的能力：1）继续为长期的学术教学和研究经验提供 赞比亚的八位现任硕士和三名现任博士学位学生，并招募了另外四个硕士 另外两名博士生； 2）为培训提供中期（六个月至一年）的技术培训 在与分子病理学，癌症生物学，生物信息学和基因组学有关的主题中； 3）交付短暂 术语培训（少于三个月）和技术研讨会（3-5天），旨在增强基本，临床， 实施，基因组学，生物信息学和行为癌症研究与其他地区合作 合作伙伴和计划。这种续签的预期结果包括八个现任大师的毕业 和三名当前的博士候选人；招募和培训另外四名硕士和两位博士学位 相关癌症研究领域的学生；过渡到学员担任精神职位的角色；增强 赞比亚机构的基础设施，包括完成CDH实验室改革；并扩展 与其他D43计划的合作伙伴关系。鉴于当前的进展和预期的续订结果，Amtrip是 有望在未来更新中向下一代癌症研究人员的过渡计划领导力。