Multi-modal vestibular perception

多模态前庭知觉

• 批准号: 10054969
• 负责人: Benjamin T Crane
• 金额: $ 32.73万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054969
• 关键词: Acceleration; Acoustic Neuroma; Acute; Attention; Auditory; Brain Concussion; Calibration; Characteristics; Chronic; Clinical; Complex; Cues; Data; Dementia; Disease; Dizziness; Environment; Etiology; Evaluation; Exhibits; Exposure to; Functional disorder; Future; Gentamicins; Hearing; Human; Individual; Lesion; Longitudinal Studies; Measures; Meniere' s Disease; Methods; Migraine; Motion; Motion Perception; Motion Sickness; Movement; Pathologic; Pathology; Patients; Perception; Physiological; Physiology; Plant Roots; Play; Population; Process; Proprioception; Reflex action; Rehabilitation therapy; Reporting; Reproducibility; Role; Rotation; Self Perception; Sensory; Side; Stimulus; Symptoms; System; Techniques; Testing; Therapeutic; Time; Translations; Vertigo; Vestibular loss; Vision; Visual; Visual Fields; Visual Motion; Visual system structure; Work; clinical investigation; clinically significant; experience; fall risk; improved; multimodality; multisensory; novel; otoconia; research clinical testing; sensory stimulus; sensory system; tool; vestibular reflex; virtual environment; virtual reality simulation; visual stimulus; visual-vestibular

Project Summary Dizziness, vertigo, motion sickness, and simulator sickness are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on reflex function and perception of isolated vestibular stimuli. However, vestibular reflex function is poorly correlated with perceptual symptoms. Perception of self-motion is at the root of understanding navigation, dizziness, motion sickness, and simulator sickness. Self-motion perception is also multi-sensory and primarily involves the vestibular and visual systems, although auditory and proprioception also may play a role in some situations. In many common clinical disorders, perceptual testing is the first line of clinical investigation. For instance an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of self-motion perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on unimodal stimuli of perceptual thresholds and tests of visual vertical which do not address the more complex multisensory situations in which self-motion is usually experienced. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate, multisensory context. The project will measure visual-vestibular integration and define the conditions where it occurs. Visual motion can be ambiguously interpreted as self-motion through a fixed environment, environmental motion relative to a fixed observer, or inaccurate sensory calibration. The project will examine all of these possibilities but determining the factors involved in determining common causation which is essential for knowing if visual motion is a result of self-motion and can be integrated with vestibular cues or is the result of external motion and should be segregated. The project will also look at mechanism adaptation in two contexts – exposure to consistently offset visual and inertial stimuli and exposure to a rotating environment. This will be examined in normal controls but also individuals with unilateral loss of vestibular function. Developing a method of adaptation that is effective in vestibular pathology will be helpful in developing tools that are potential methods of future vestibular rehabilitation.

项目摘要 头晕，眩晕，运动疾病和模拟器疾病是扎根的常见临床问题 对运动的异常感知。前庭系统的临床测试和对前庭的理解 生理学从历史上一直集中在反射功能和对孤立前庭刺激的感知上。然而， 前庭反射功能与感知症状相关。自我运动的感知是根源 了解导航，头晕，运动疾病和模拟器疾病。自我运动感知是 同样，多感官和初级涉及前庭和视觉系统，尽管听觉和 本体感受也可能在某些情况下发挥作用。在许多常见的临床疾病中，感知测试 是临床投资的第一线。例如，视觉评估通常始于 病人报告他们能够看到的听证和评估始于测试患者能够 听到。但是，对自我运动感知的理解尚未处于感知测试为 临床上有意义。先前关于前庭感知的大多数工作都集中在单峰刺激上 视觉垂直方面的感知阈值和测试无法解决更复杂的多感官 通常会经历自我运动的情况。当前的建议旨在提高对 人类运动感知到临床和身体相关的领域，通过研究这种看法 适当的多感官上下文。该项目将衡量视觉范围的整合并定义 发生的情况。视觉运动可以模棱两可地解释为通过固定的 环境，相对于固定观察者或不准确的感觉校准的环境运动。项目 将检查所有这些可能性，但要确定确定共同原因所涉及的因素 这对于了解视觉运动是否是自我运动的结果至关重要，并且可以与前庭集成 提示或是外部运动的结果，应隔离。该项目还将研究机制 在两种情况下进行适应 - 暴露于始终抵消视觉和惯性刺激以及暴露于 旋转环境。这将在正常对照中进行检查，但也将 前庭功能。开发一种在前庭病理中有效的适应方法将有所帮助 开发是未来前庭康复的潜在方法的工具。