Multi-modal vestibular perception

多模态前庭知觉

• 批准号: 8815425
• 负责人: Benjamin T Crane
• 金额: $ 36.08万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8815425
• 关键词: Address; Attention; Benign; Clinical; Clinical Pathology; Cues; Darkness; Data; Discrimination; Disorientation; Dizziness; Environment; Esthesia; Evaluation; Event; Exposure to; Eye; Feeling; Frequencies; Friends; Future; Head; Hearing; Human; Individual; Labyrinth; Lead; Lesion; Measurement; Measures; Methods; Migraine; Modality; Modeling; Motion; Motion Perception; Motor; Movement; Neck; Organ; Pathology; Patient Self-Report; Patients; Pattern; Perception; Physiology; Plant Roots; Population; Positioning Attribute; Proprioception; Psychometrics; Public Health; Reflex action; Relative (related person); Reporting; Resources; Retina; Rotation; Sensory; Severities; Side; Source; Stimulus; Symptoms; System; Techniques; Testing; Translations; Vertigo; Vision; Visual Fields; Visual Motion; Walking; Weight; Work; auditory stimulus; base; clinical investigation; clinically relevant; clinically significant; experience; fall risk; falls; improved; insight; motion sensitivity; optic flow; patient population; public health relevance; research clinical testing; research study; sensory stimulus; somatosensory; vestibular reflex; visual stimulus; visual-vestibular

DESCRIPTION (provided by applicant): Dizziness and vertigo are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on simple stimuli and reflex function. However, vestibular reflex function is poorly correlated with perceptual symptoms. In other sensory modalities perceptual testing is the first line of clinical investigation. For instane an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of vestibular perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on measurement of perceptual thresholds - essentially determining if someone can sense the direction of an isolated movement in a dark room. This situation does not address the more clinically relevant situations in which each movement occurs in the context of ongoing motion which include both translation and rotation components as well as other sensory stimuli such as motor and proprioception. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate context. The project will also test psychometric methods to determine which is most appropriate for measurement of vestibular biases. Some combinations of head rotation and translation are more benign and likely to occur during ambulation while others may be indicative of a perturbation that may lead to a fall. The project will look how proceeding movements influence motion perception such that a movement that is similar to a previous one is less likely to be perceived. It is common for people to make large voluntary movements without becoming disoriented, such as looking to the side to talk to a friend while walking. This may be easy for us because we perceive our motion in a body-centered reference frame rather than head-centered one, even though the vestibular organs are in the head. How this sensory transformation occurs will be investigated for heading estimation. Visual stimuli also provide a powerful cue to self-motion perception, especially when the visible motion involves a large part of the visual field and persists for several seconds. This perception is often referred to as vection and may also be related to motion sensitivity in some patient populations. A method of quantifying vection by comparing it with actual motion will be developed. This will be useful for determining if vection and self-motion are perceived equivalently as well as proving an objective method of assessing visual motion sensitivity.

描述（由申请人提供）：头晕和眩晕是基于对运动异常感知的常见临床问题。前庭系统的临床测试和对前庭生理学的理解历史上一直集中在简单的刺激和反射功能上。但是，前庭反射功能与感知症状的相关性很差。在其他感觉方式中，感知测试是临床研究的第一线。对于Instane，对视力的评估通常始于让患者报告他们能够看到的内容，而对听证会的评估始于测试患者能够听到的内容。但是，对前庭感知的理解尚未处于临床上感知测试的状态 有意义。先前关于前庭感知的大多数工作都集中在评估感知阈值上 - 本质上确定某人是否可以感觉到黑暗房间中孤立运动的方向。这种情况无法解决在临床上相关的情况，在这种情况下，每个运动都在持续运动的背景下发生，包括翻译和旋转成分以及其他感觉刺激，例如运动和原则。当前的提案旨在通过在适当的情况下检查这种看法，将对人运动感知的理解纳入临床和生理相关的领域。该项目还将测试心理测量方法，以确定哪种最适合于前庭偏差的测量。头部旋转和翻译的某些组合更加良性，并且可能在行动过程中发生，而其他人可能表明可能导致跌倒的扰动。该项目将研究过程的影响如何影响运动感知，从而使与前一个运动相似的运动不太可能被感知。人们通常会在不迷失方向的情况下进行大型自愿运动，例如在步行时向一边与朋友交谈。这对我们来说可能很容易 因为我们在以身体为中心的参考框架中感知我们的运动，而不是以头为中心的运动框架，即使前庭器官在头部。将研究这种感觉转换的方式以进行标题估计。视觉刺激还为自我运动感知提供了强大的提示，尤其是当可见运动涉及视野的很大一部分时 持续几秒钟。这种看法通常称为互动，也可能与某些患者人群的运动灵敏度有关。通过将其与实际运动进行比较来量化传感的方法。这对于确定互动和自我运动是否等效以及证明一种评估视觉运动灵敏度的客观方法将很有用。