Visual and Vestibular Percepts of Motion

运动的视觉和前庭知觉

• 批准号: 8028612
• 负责人: Benjamin T Crane
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8028612
• 关键词: Acceleration; Acoustic Stimulation; Area; Attention; Bilateral; Caloric Tests; Clinical; Cues; Dependence; Development; Diagnosis; Diagnostic; Diagnostic tests; Disabled Persons; Discrimination; Disease; Dizziness; Equipment and supply inventories; Esthesia; Exposure to; External Canal; Frequencies; Future; Goals; Head; Hearing; Human; Human Pathology; Illusions; Individual; Investigation; Irrigation; Laboratories; Lesion; Measurement; Measures; Mediating; Migraine; Monitor; Motion; Motion Perception; Movement; Noise; Online Systems; Organ; Pathologic; Pathology; Patients; Perception; Performance; Peripheral; Physicians; Population; Productivity; Psychophysiology; Reflex action; Rehabilitation therapy; Relative (related person); Reporting; Role; Rotation; Screening procedure; Self Perception; Semicircular canal structure; Severities; Side; Source; Speed; Stimulus; Symptoms; System; Systems Integration; Techniques; Test Result; Testing; Therapeutic; Time; Translations; Utricle structure; Vertigo; Vestibular loss; Vision; Visit; Visual; Visual Motion; Weight Perception; Work; Yaws; base; clinical Diagnosis; clinical application; disorder control; falls; handicapping condition; improved; instrument; movie; novel diagnostics; optic flow; otoconia; rehabilitation strategy; research clinical testing; research study; response; sensory system; tool; vestibulo-ocular reflex; visual feedback; visual stimulus; visual-vestibular

DESCRIPTION (provided by applicant): This project aims to characterize human motion perception as mediated by vision, vestibular system, and the interactions between them. The project is divided into 3 main areas: vestibular perception, visual-vestibular interaction, and visual motion perception. The vestibular perception component will focus on determination of translation, heading perception, and rotation in normal controls and individuals with unilateral and bilateral peripheral vestibular lesions in the absence of visual cues. Differences in these populations may provide better understanding of vestibular sensitivity, including potential direction biases in sensitivity in those with unilateral lesions and form the basis of future diagnostic testing. Subjects with bilateral vestibular loss may provide clues to the roll of somatic sensation on motion perception. Vision has a significant role in motion perception, and patient's dizziness symptoms can result from derangements in integration of vision and vestibular cues. The most simple interaction between visual and vestibular perception occurs during rotation near the perceptual threshold in the presence of a visible, head fixed object. Paradoxically, in this situation a visible object has been shown to decrease the motion perception threshold. We plan to study this effect with moving objects and in individuals with known pathology in the visual-vestibular integration system such as occurs in migraine associated vertigo (MAV). Using this paradigm we also plan to explore perceptual differences between self and external rotation. We also plan to study the roles visual-vestibular interaction during translation using optic flow with motion to determine heading perception, in normal controls, MAV, and vestibulopathy subjects. Through these experiments we hope to quantify the influences of vision and vestibular senses on motion perception, and how the relative importance of these influences changes in pathological states. Many prior perceptual studies have used 2-alterative forced choice (2AFC) paradigms which are scientifically rigorous, but time consuming. Potential short cuts 2AFC that will speed testing and allow possible clinical applications will be explored. Dizziness in response to visual motion such as panning of the scene on a movie screen or looking out the side window of a moving vehicle is a disorienting source of dizziness complaints in MAV patients which often limits their daily activities. We plan to investigate the potential for visual motion as a diagnostic and rehabilitation strategy in these subjects. Using a specially developed web-based application, control and MAV subjects will complete a subjective visual vertical (SVV) task. The effect of background motion will be determined as well as tolerance to the stimuli. Subjects will regularly use the application over time while periodically reporting their dizziness symptoms using validated clinical instruments. The potential diagnostic value of the task, its correlation with symptom severity, and potential as a rehabilitation strategy will be investigated. PUBLIC HEALTH RELEVANCE: Disorders of the vestibular system are a common source of doctor's visits and can be the source of lost work productivity and falls. These disorders are often not correctly diagnosed or treated due to poor understanding and limitations in current diagnostic testing. This proposal aims to improve understanding of these disorders and explore new diagnostic and rehabilitation strategies.

描述（由申请人提供）：该项目旨在将人类运动感知表征为视觉，前庭系统及其之间的相互作用。该项目分为三个主要领域：前庭感知，视觉 - 视觉相互作用和视觉运动感知。前庭感知成分将集中于在没有视觉提示的情况下，在正常对照组以及具有单侧和双侧外围前庭病变的正常对照组和个体中的转换，标题感知和旋转。这些人群的差异可能会更好地理解前庭敏感性，包括具有单侧病变患者的敏感性的潜在方向偏见，并构成了将来诊断测试的基础。双侧前庭损失的受试者可能会为运动感知的躯体感觉卷提供线索。视力在运动感知中起着重要作用，患者的头晕症状可能是由于视力和前庭提示的整合而造成的。视觉和前庭感知之间最简单的相互作用发生在存在可见的头部固定物体的情况下，在感知阈值附近的旋转期间发生。矛盾的是，在这种情况下，已显示可见对象可降低运动感知阈值。我们计划通过移动对象和在视觉范围内积分系统中有已知病理学的个体（例如偏头痛相关的眩晕（MAV））研究这种效果。使用此范式，我们还计划探索自我和外部旋转之间的感知差异。我们还计划在翻译过程中使用光学流动与运动的视觉相互作用研究角色，以确定标题感知，在正常对照，MAV和前庭病主题中。通过这些实验，我们希望量化视力和前庭感知运动感知的影响，以及这些影响如何影响病理状态的变化。许多先前的知觉研究使用了两种疗法的强制选择（2AFC）范式，这些范式在科学上是严格但耗时的。潜在的捷径2AFC将加快测试并允许可能的临床应用。头晕目眩，如视觉运动，例如在电影屏幕上平移场景或在移动车辆的侧窗外看是MAV患者中令人发指的头晕投诉的一种迷失来源，这通常会限制他们的日常活动。我们计划在这些受试者中研究视觉运动作为诊断和康复策略的潜力。使用专门开发的基于Web的应用程序，Control和MAV主题将完成主观的视觉垂直（SVV）任务。背景运动的影响将被确定以及对刺激的耐受性。受试者将随着时间的推移定期使用该应用程序，同时使用经过验证的临床仪器定期报告头晕症状。任务的潜在诊断价值，其与症状严重程度的相关性以及作为康复策略的潜力。 公共卫生相关性：前庭系统的疾病是医生就诊的常见来源，并且可能是失去工作效率和跌倒的来源。由于当前诊断测试中的理解和局限性，这些疾病通常无法正确诊断或治疗。该建议旨在提高对这些疾病的理解，并探索新的诊断和康复策略。