Multi-modal vestibular perception

多模态前庭知觉

• 批准号: 10540766
• 负责人: Benjamin T Crane
• 金额: $ 32.73万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540766
• 关键词: Acceleration; Acoustic Neuroma; Acute; Attention; Auditory; Brain Concussion; Calibration; Characteristics; Chronic; Clinical; Complex; Cues; Data; Dementia; Disease; Dizziness; Environment; Etiology; Evaluation; Exhibits; Exposure to; Functional disorder; Future; Gentamicins; Hearing; Human; Individual; Lesion; Longitudinal Studies; Measures; Meniere' s Disease; Methods; Migraine; Motion; Motion Perception; Motion Sickness; Movement; Pathologic; Pathology; Patients; Perception; Physiological; Physiology; Population; Process; Proprioception; Reflex action; Rehabilitation therapy; Reporting; Reproducibility; Rotation; Self Perception; Sensory; Side; Stimulus; Symptoms; System; Techniques; Testing; Therapeutic; Time; Translations; Vertigo; Vestibular loss; Vision; Visual; Visual Fields; Visual Motion; Visual System; Work; clinical investigation; clinically significant; experience; fall risk; improved; multimodality; multisensory; novel; otoconia; research clinical testing; segregation; sensory stimulus; sensory system; tool; vestibular reflex; virtual environment; virtual reality simulation; visual stimulus; visual-vestibular

Project Summary Dizziness, vertigo, motion sickness, and simulator sickness are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on reflex function and perception of isolated vestibular stimuli. However, vestibular reflex function is poorly correlated with perceptual symptoms. Perception of self-motion is at the root of understanding navigation, dizziness, motion sickness, and simulator sickness. Self-motion perception is also multi-sensory and primarily involves the vestibular and visual systems, although auditory and proprioception also may play a role in some situations. In many common clinical disorders, perceptual testing is the first line of clinical investigation. For instance an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of self-motion perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on unimodal stimuli of perceptual thresholds and tests of visual vertical which do not address the more complex multisensory situations in which self-motion is usually experienced. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate, multisensory context. The project will measure visual-vestibular integration and define the conditions where it occurs. Visual motion can be ambiguously interpreted as self-motion through a fixed environment, environmental motion relative to a fixed observer, or inaccurate sensory calibration. The project will examine all of these possibilities but determining the factors involved in determining common causation which is essential for knowing if visual motion is a result of self-motion and can be integrated with vestibular cues or is the result of external motion and should be segregated. The project will also look at mechanism adaptation in two contexts – exposure to consistently offset visual and inertial stimuli and exposure to a rotating environment. This will be examined in normal controls but also individuals with unilateral loss of vestibular function. Developing a method of adaptation that is effective in vestibular pathology will be helpful in developing tools that are potential methods of future vestibular rehabilitation.

项目概要 头晕、眩晕、晕动病和模拟器病是常见的临床问题，其根源在于 前庭系统的异常感知和对前庭的理解。 生理学历来关注反射功能和孤立前庭刺激的感知。 前庭反射功能与知觉症状的相关性较差。 理解导航、头晕、晕动病和模拟器病的关键是。 也是多感官的，主要涉及前庭和视觉系统，尽管听觉和听觉系统 本体感觉在某些情况下也可能发挥作用，在许多常见的临床疾病中，知觉测试。 是临床研究的第一线，例如，视力评估通常从获得视力开始。 患者报告他们能够看到的内容，听力评估从测试患者能够看到的内容开始 然而，对自我运动知觉的理解还没有达到知觉测试的阶段。 以前关于前庭知觉的大部分工作都集中在单峰刺激上。 知觉阈值和视觉垂直测试不能解决更复杂的多感官问题 当前的提案旨在增进对通常经历自我运动的情况的理解。 通过在一个特定的环境中检查人类运动感知到临床和生理相关领域 该项目将测量视觉前庭整合并定义 视觉运动可以被模糊地解释为通过固定的自我运动。 环境、相对于固定观察者的环境运动或不准确的感官校准。 将检查所有这些可能性，但确定参与确定共同因果关系的因素 这对于了解视觉运动是否是自我运动的结果以及是否可以与前庭整合至关重要 提示或是外部运动的结果，并且应该被隔离该项目还将考虑机制。 两种情况下的适应——暴露于持续抵消的视觉和惯性刺激以及暴露于 这将在正常对照中进行检查，但也会在单侧丧失能力的个体中进行检查。 开发一种对前庭病理学有效的适应方法将有助于 开发作为未来前庭康复的潜在方法的工具。