Monitoring and control of human liver cancer ablation using real-time, 3D echo decorrelation imaging
使用实时 3D 回波去相关成像监测和控制人类肝癌消融
基本信息
- 批准号:10006862
- 负责人:
- 金额:$ 35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-08-10 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAblationAccountingAdverse effectsAlgorithmsBlindedCancer PatientCattleCell DeathCirrhosisClinicClinicalClinical TrialsComputersDataDisseminated Malignant NeoplasmElectrodesEnvironmentExcisionFamily suidaeFeedbackFoundationsFutureGenderGoldHeatingHistologyHumanImageInvestigationLeadLiverLiver diseasesLiver neoplasmsLiver parenchymaLocalized Malignant NeoplasmMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of liverMapsMetastatic Neoplasm to the LiverMethodsModalityMonitorMorbidity - disease rateMotionNeoplasm MetastasisOperative Surgical ProceduresOryctolagus cuniculusPathologicPatient SchedulesPatientsPerformancePrediction of Response to TherapyPrimary NeoplasmPrimary carcinoma of the liver cellsProceduresPublic HealthROC CurveRadiofrequency Interstitial AblationRecurrenceResearchResectedRiskSafetySpecific qualifier valueSpecimenTestingThermal Ablation TherapyThree-Dimensional ImagingTimeTissuesTransducersTranslatingTranslationsTransplantationUltrasonographyUnresectableValidationX-Ray Computed Tomographycancer recurrencecancer therapyclinical practicecommon treatmentcontrast enhanceddirect applicationfollow-upimaging modalityimprovedimproved outcomein vivoinnovationliver tumor ablationmicrowave ablationmillisecondminimally invasivemortalitynovelnovel strategiesperformance testspreventradio frequencyreal time monitoringside effectstandard of caresuccesssurgery outcometumortumor ablation
项目摘要
Project Summary/Abstract
Liver cancer, including hepatocellular carcinoma (HCC) as well as metastatic tumors, is a major public health
problem. For patients with unresectable liver cancer, thermal ablation, including radiofrequency ablation (RFA)
and microwave ablation (MWA), is the current clinical standard of care; however, thermal ablation methods are
limited by non-uniform and inconsistent treatment, leading to adverse side effects, local cancer recurrence, and
decreased survival, severely limiting their clinical utility.
Echo decorrelation imaging is a novel ultrasound approach that mitigates these problems by mapping
ultrasound echo changes caused by tissue heating during thermal ablation. Research to date on echo
decorrelation imaging has shown that this method reliably predicts ablation-induced cell death in vivo for rabbit
and porcine liver tissue as well as VX2 liver cancer. Although echo decorrelation imaging is an extremely
promising approach to thermal ablation monitoring and control, its translation to clinical practice will require
validation of real-time, 3D ablation monitoring and control for human liver cancer ablation, including different
tumor types (HCC and metastatic), as well as normal and abnormal human liver parenchyma (e.g., cirrhotic
liver). Our central hypothesis for this study is that real-time monitoring and control by 3D echo decorrelation
imaging will improve reliability of human liver tumor ablation.
To test this hypothesis, we will implement 3D, real-time echo decorrelation imaging using a clinical
ultrasound scanner and matrix array transducers, then validate the application of 3D echo decorrelation
imaging to RFA and MWA. Methods for controlled ablation will be implemented for RFA using standard clinical
electrodes and a clinical radiofrequency generator, with echo decorrelation serving as a treatment end point.
To test the performance of clinical echo decorrelation imaging in human primary and metastatic cancer as well
as diseased liver tissue, 3D echo decorrelation images will be formed from echo data recorded during open
surgical RFA and percutaneous MWA procedures, then compared with follow-up contrast MRI and CT to
assess prediction of ablated volume margins as well as local recurrence. Control of thermal ablation by 3D
echo decorrelation imaging will first be studied in resected specimens of human metastatic liver cancer with
normal liver tissue margins and specimens of cirrhotic human liver tissue, as well as in vivo swine liver. The
study will then culminate in a treat-and-resect trial of echo decorrelation-controlled radiofrequency ablation in
liver tumor patients, demonstrating the direct application of echo decorrelation imaging to improving clinical
tumor ablation. This research will thus show feasibility for both effective prediction and real-time control of liver
cancer ablation in human liver cancer and concomitant diseased liver tissue.
项目摘要/摘要
肝癌,包括肝细胞癌(HCC)和转移性肿瘤,是主要的公共卫生
问题。对于肝癌不可切除的患者,热消融,包括射频消融(RFA)
和微波消融(MWA)是当前的临床护理标准;但是,热消融方法是
受到不均匀和不一致的治疗的限制,导致不良副作用,局部癌症复发和
生存下降,严重限制了其临床效用。
回声去相关成像是一种新型的超声方法,可以通过映射来减轻这些问题
超声回声变化是由热消融过程中组织加热引起的。迄今为止在Echo上进行的研究
去相关成像表明,这种方法可靠地预测兔子的消融诱导的细胞死亡
和猪肝组织以及VX2肝癌。虽然回声去相关成像是极其的
有希望的热消融监测和控制的方法,其转化为临床实践将需要
实时,3D消融监测和控制人肝癌消融的验证,包括不同的
肿瘤类型(HCC和转移性),以及正常和异常的人肝实质(例如,肝硬化
肝脏)。我们在这项研究的中心假设是通过3D Echo DeTorlation实时监测和控制
成像将提高人肝肿瘤消融的可靠性。
为了检验这一假设,我们将使用临床实施3D实时回声去相关成像
超声扫描仪和矩阵阵列换能器,然后验证3D Echo去相关的应用
成像RFA和MWA。将使用标准临床来实施RFA的控制消融方法
电极和临床射频发生器,回声去相关用作治疗终点。
还可以测试人类原发性和转移性癌症中临床回声去相关成像的性能
作为患病的肝组织,将从开放期间记录的回声数据形成3D回声去相关图像
然后将手术RFA和经皮MWA程序与随访对比度MRI和CT进行比较
评估消融体积边缘以及局部复发的预测。 3D控制热消融
回声去相关成像将首先在切除的人类转移性肝癌标本中进行研究
正常的肝组织边缘和肝硬化人肝组织的标本以及体内猪肝脏。这
然后,研究将在回声解往与控制的射频消融中的治疗和分支试验中达到高潮
肝肿瘤患者,证明回声去相关成像直接应用于改善临床
肿瘤消融。因此,这项研究将显示出对肝脏有效预测和实时控制的可行性
人肝癌和伴随患病肝组织的癌症消融。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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T Douglas Mast其他文献
T Douglas Mast的其他文献
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{{ truncateString('T Douglas Mast', 18)}}的其他基金
Monitoring and control of human liver cancer ablation using real-time, 3D echo decorrelation imaging
使用实时 3D 回波去相关成像监测和控制人类肝癌消融
- 批准号:
10176156 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Real-time prediction of thermal ablation-induced cell death by echo decorrelation
通过回波去相关实时预测热消融诱导的细胞死亡
- 批准号:
8676729 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Real-time prediction of thermal ablation-induced cell death by echo decorrelation
通过回波去相关实时预测热消融诱导的细胞死亡
- 批准号:
8294016 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Monitoring and control of human liver cancer ablation using real-time, 3D echo decorrelation imaging
使用实时 3D 回波去相关成像监测和控制人类肝癌消融
- 批准号:
9531604 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Real-time prediction of thermal ablation-induced cell death by echo decorrelation
通过回波去相关实时预测热消融诱导的细胞死亡
- 批准号:
8528513 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Monitoring and control of human liver cancer ablation using real-time, 3D echo decorrelation imaging
使用实时 3D 回波去相关成像监测和控制人类肝癌消融
- 批准号:
10410489 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Real-time prediction of thermal ablation-induced cell death by echo decorrelation
通过回波去相关实时预测热消融诱导的细胞死亡
- 批准号:
8857112 - 财政年份:2012
- 资助金额:
$ 35万 - 项目类别:
Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation
用于引导和控制超声消融的被动空化成像
- 批准号:
7571142 - 财政年份:2009
- 资助金额:
$ 35万 - 项目类别:
Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation
用于引导和控制超声消融的被动空化成像
- 批准号:
7756672 - 财政年份:2009
- 资助金额:
$ 35万 - 项目类别:
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