Magnetic Bronchoscope for Improved Pulmonary Access

用于改善肺部通路的磁力支气管镜

基本信息

批准号：
10152980
负责人：
WALTER BLUME
金额：
$ 40.14万
依托单位：
UNANDUP, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152980
关键词：
3-Dimensional 3D Print Ablation Accounting Acrylates Adoption American Angiography Animals Biopsy Biopsy Specimen Bronchoscopes Bronchoscopy Caliber Cancer Etiology Cause of Death Cessation of life Clinical Complex Complication Data Data Set Detection Device Designs Devices Diagnosis Distal Early Diagnosis Fatigue Forcep Genes Goals Hospitals Human In Vitro Institution Intervention Joystick Learning Length Lesion Lung Lung nodule Magnetism Malignant Neoplasms Malignant neoplasm of lung Manuals Measurement Measures Mechanics Metals Modality Needle biopsy procedure Needles Nodule Optics Outcome Pathway interactions Performance Phase Pneumothorax Positioning Attribute Price Procedures Property Research Personnel Resolution Robotics Roentgen Rays Safety Sampling Shapes Staging Statistical Methods Structure Surface System Technology Time Tissue Sample Treatment Protocols Underserved Population United States Visualization Width X-Ray Computed Tomography arm base cancer therapy cost cost effective early screening flexibility imaging detection improved magnetic field meetings meter mortality novel performance tests pre-clinical prevent productivity loss prototype robotic system safety assessment sensor standard of care success tool usability

项目摘要

One of every 16 Americans will be diagnosed with lung cancer in their lifetime. Each year in the United States there are nearly 250,000 new diagnoses and 150,000 deaths with an estimated productivity loss in excess of $20 billion. Thanks to recent advancements in CT imaging, detection of smaller suspicious pulmonary nodules within distal regions of the lung is now possible. As a result, mortality rates have decreased by nearly 20% due to earlier initiation of treatment protocols. The ability to safely obtain a viable biopsy sample is critical. However, despite the availability of better CT imaging, little progress has been made in expanding affordable tools which can safely access distal regions of the lung to diagnose and stage suspicious nodules. Percutaneous needle biopsy remains the standard of care used to obtain nodule tissue samples, although the procedure is associated with pneumothorax complication rates greater than 20%. In contrast, bronchoscopes are 10X safer when used to acquire biopsies. However, bronchoscopes possess two main limitations which result in many lung cancers not being successfully diagnosed. First, the relatively large size prevents them from being able to access most of the lung. Second, because the bronchoscope’s tip is manipulated from nearly a meter away using complex pull-wire based mechanisms, limited control of the tip is provided which largely restricts biopsy to nodules within the airway. To improve upon manual bronchoscopes, robotic solutions have been developed; however, these technologies are difficult to learn, do not greatly improve distal access or tip control, and are prohibitively expensive (~$500k) for most hospitals. As a result, adoption of robotics for bronchoscopy has been slow. UNandUP has invented a novel robotic bronchoscopy platform that provides precise control of the bronchoscope’s tip using a smaller scope diameter than previously possible that enables safe access into otherwise inaccessible lung regions and the ability to better biopsy nodules not directly in the airway. By overcoming the complexities of traditional robotic approaches, the proposed technology can be priced at a fraction of the cost of competing robotic solutions. This will allow advanced lung biopsy capabilities to be offered to nearly all hospital versus only being available at select institutions. Importantly, the technology also promises to serve as an exploratory platform for emerging cancer therapies which include gene, photodynamic, and ablation therapies. The project’s aims include 1) building the robotic workstation, 2) building a steerable bronchoscope, and 3) assessing performance in CT-based bronchial phantoms.

在美国，每年每 16 个美国人中就有一个被诊断出患有肺癌。新增确诊病例近 25 万人，死亡人数 15 万人，生产力损失估计超过得益于 CT 成像技术的最新进展，可检测较小的可疑肺部结节。因此，死亡率下降了近 20%。安全获取可行的活检样本的能力对于尽早开始治疗方案至关重要。然而，尽管有了更好的 CT 成像技术，但在扩大负担得起的方面却进展甚微。可以安全地进入肺部远端区域以诊断和分期可疑结节的工具。经皮穿刺活检仍然是获取结节组织样本的护理标准，尽管相比之下，支气管镜手术的气胸并发症发生率超过 20%。用于获取活检时安全性高 10 倍然而，支气管镜有两个主要局限性：导致许多肺癌未能成功诊断，首先，相对较大的体积阻碍了它们。其次，因为支气管镜的尖端是从肺部操作的。使用复杂的基于拉线的机构，在近一米之外提供对尖端的有限控制，很大程度上限制了对气道内结节的活检为了改进手动支气管镜、机器人解决方案。已经开发出来；然而，这些技术很难学习，并不能极大地改善远端接入或尖端控制，对于大多数医院来说都非常昂贵（约 50 万美元），因此采用机器人技术。 UNandUP 发明了一种新型机器人支气管镜检查平台，该平台提供了支气管镜检查的缓慢进展。使用比以前更小的内窥镜直径精确控制支气管镜尖端，从而能够安全进入原本无法进入的肺部区域，并且能够更好地活检结节，而不是直接在肺部通过克服传统机器人方法的复杂性，所提出的技术可以这将使先进的肺活检功能的价格仅为竞争机器人解决方案成本的一小部分。几乎所有医院都可以使用该技术，而不是仅在选定的机构中使用。还承诺作为新兴癌症疗法的探索平台，其中包括基因、该项目的目标包括 1) 建造机器人工作站，2) 建造。可操纵支气管镜，3) 评估基于 CT 的支气管模型的性能。