16/24 Healthy Brain and Child Development National Consortium DIVERSITY SUPPLEMENT

16/24 健康大脑和儿童发展国家联盟多样性补充

• 批准号: 10765565
• 负责人: Nathan A Fox
• 金额: $ 5.88万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765565
• 关键词: 10 year old; Acceleration; Adolescence; Adolescent; Anxiety; Behavioral; Biological; Brain; Caregivers; Child; Child Development; Childhood; Cognitive; Data; Data Collection; Development; Emotional; Environment; Faculty; Genetic; Individual; Mental Health; Outcome; Pregnant Women; Public Health; Research; Research Personnel; Risk Factors; Stress; Structure; Teenagers; Thick; Training; Variant; Work; adverse outcome; behavioral health; behavioral outcome; brain volume; career; depressive symptoms; fetal drug exposure; fetal substance exposure; graduate school; graduate student; infancy; interest; offspring; parent grant; parent project; postnatal; prenatal; prospective; resilience; social; sociodemographic factors; substance use; training project

Abstract Substance use among pregnant women is a substantial public health concern that can result in adverse outcomes in offspring. The aims of the Healthy Brain and Child Development (HBCD) parent grant are to: 1) examine behavioral, cognitive, biological, social, and emotional aspects of child development from prenatal to 10 years old and 2) examine the impacts of sociodemographic factors, stress and mental health, genetics, and prenatal substance exposure on child development. However, the parent project is focused on data collection and on the developmental periods of infancy and childhood. The proposed work will use existing data from the F.U.T.U.R.E.S. study (“Following Urban Teens: Unique and Resilient at Every Step, DA021059 ), which examined the impact of prenatal substance exposure on behavioral and brain development in adolescence. In Aim 1 of this proposed supplement, the Candidate will examine interactions between PDE and caregiver mental health on behavioral outcomes in adolescence. We hypothesize that the combination of PDE and poor caregiver mental health (characterized by symptoms of depression, anxiety, and/or stress) will produce the worst child outcomes. Exploratory analyses will probe whether effects vary as a function of type of substance or duration of use. In Aim 2, the Candidate will examine interactions between PDE and caregiver mental health on adolescent brain structure and function. We hypothesize that the combination of PDE and poor caregiver mental health will be associated with variations in brain volume and cortical thickness compared to individuals with either one risk-factor alone or no risk factors. This work will provide a better understanding of maternal mental health and caregiver environment that influence many aspects of child development. As a full-time faculty researcher, the Candidate does not have the opportunity to explore research interests outside of the parent project and pursue training that would make her a competitive prospective graduate student. Ultimately, this training project will help accelerate the Candidate’s transition to graduate school and her research career trajectory.

抽象的 孕妇吸毒是一个重大的公共卫生问题，可能导致 健康大脑和儿童发展 (HBCD) 的目标。 家长补助金的目的是： 1) 检查行为、生物、社会和情感方面 从产前到十岁的儿童发育 岁和 2）检查的影响 社会人口因素、压力和心理健康、遗传以及 产前物质暴露 然而，父项目的重点是数据收集和 婴儿期和发育期 拟议的工作将使用童年时期的现有数据。 F.U.T.U.R.E.S. 研究（“跟随城市青少年：每一步都独特而有弹性， DA021059 ），研究了产前物质暴露对行为和行为的影响 在本拟议补充的目标 1 中，候选人将 检查 PDE 和护理人员心理健康之间的相互作用对行为结果的影响 我们为 PDE 和看护者心理健康状况不佳的结合而苦苦挣扎。 （其特点是 抑郁、焦虑和/或压力的症状）会产生最糟糕的孩子 探索性分析将探讨效果是否随类型的变化而变化。 在目标 2 中，考生将检查 PDE 之间的相互作用。 和照顾者心理健康对青少年大脑的影响 结构和功能。 PDE 和护理人员心理健康状况不佳的结合将与大脑的变化相关 与仅具有一种风险因素或没有风险的个体相比的体积和皮质厚度 这项工作将。 更好地了解母亲的心理健康和护理人员 作为一名全职教师研究员，影响儿童发展的许多方面的环境。 候选人没有机会 探索父母之外的研究兴趣 项目并进行培训，使她 一个有竞争力的未来研究生。 最终， 该培训项目将有助于加速候选人向研究生院的过渡 以及她的研究生涯轨迹。