Does biogeography select for human disease patterns among Salmonella serovars

生物地理学是否选择沙门氏菌血清型中的人类疾病模式

• 批准号: 7940093
• 负责人: Sonia Hernandez-Divers
• 金额: $ 44.49万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-07 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940093
• 关键词: Accounting; Address; Affect; Animal Diseases; Animals; Behavior; Biology; Blood Circulation; Cessation of life; Clinical; Complex; Country; Custom; Discipline; Disease; Disease Outbreaks; Ecology; Enteral; Environment; Environmental Microbiology; Epidemiology; Food; Genetic; Geographic Locations; Geography; Goals; Grant; Health; Hospitalization; Human; Incidence; Infection; Light; Link; Modeling; Natural History; Pattern; Physical environment; Population Density; Positioning Attribute; Prevalence; Province; Public Health; Pulsed-Field Gel Electrophoresis; Research; Research Personnel; Role; Salmonella; Salmonella enterica; Salmonella infections; Source; Southeastern United States; Stratification; Surface; United States; Veterinary Medicine; Water; Work; base; demographics; disease transmission; expectation; exposed human population; human disease; innovation; land use; novel; public health relevance; regional difference; transmission process; vector; water quality

DESCRIPTION (provided by applicant): The interplay of biology and behavior, and interactions between specific serovars, reservoir hosts, humans and the physical environment contributes to the transmission of Salmonella from non-food sources. The overall objective of this application is to establish the link between the environment and sporadic cases of salmonellosis. The central hypothesis is that unique environmental and ecological composition of a geographic region selects specific S. enterica serovars and influences human disease pattern(s). The following specific aims will be pursued: 1) compare Salmonella prevalence and serovar distribution in wildlife and the environment in distinct watersheds, and 2) identify the ecological/environmental parameters affecting the presence of specific serovars and strains among wildlife, waters and humans. The novel notion that landscape, land-use, demographics, and geography drive biogeographical patterns in Salmonella prevalence, serovar distribution and incidence of human cases will be explored through the examination of key watersheds for Salmonella carriage in wildlife, loading in surface waters, incidence of clinical human and animal disease and comparison of isolates between sources. This work will elucidate important ecological factors responsible for patterns in Salmonella serovar distribution and human disease, while providing an innovative approach to help understand the role of the environment in human enteric disease. PUBLIC HEALTH RELEVANCE: Despite continued efforts to reduce rates of Salmonella infection in the U.S., incidence remains much higher (16.2 cases/100,000) than the goal of 6.8 set for 2010 and certain regions of the country are disproportionately affected. This project aims to examine the unique environmental and ecological composition of a geographic region selects specific Salmonella enterica serovars and influences human disease patterns. This work will elucidate important ecological factors responsible for patterns in Salmonella serovar distribution and human disease, while providing an innovative approach to help understand the role of the environment in human enteric disease.

描述（由申请人提供）：生物学和行为的相互作用，以及特定血清，储层宿主，人类和物理环境之间的相互作用有助于从非食物来源传播沙门氏菌。该应用的总体目的是建立环境和零星鲑鱼类病病例之间的联系。中心假设是地理区域的独特环境和生态组成选择了特定的肠链球菌血清，并影响人类疾病模式。将追求以下具体目标：1）比较野生动植物中沙门氏菌的患病率和血清分布在不同的流域中的环境，以及2）确定影响野生动植物，水域和人类中特定血清毒素和菌株的生态/环境参数。新的观念是，将通过检查野生动植物中的野生动植物中沙门氏菌的关键水域，在地表水中负载，临床人类疾病的发生率和隔离之间的隔离率，将探索沙门氏菌患病率，血清分布和人类病例的生物地理模式的生物地理模式的新颖观念。这项工作将阐明负责沙门氏菌分布和人类疾病模式的重要生态因素，同时提供了一种创新的方法来帮助了解环境在人类肠道疾病中的作用。 公共卫生相关性：尽管在美国降低沙门氏菌感染率的努力继续努力，但发病率仍然高于2010年6.8的目标（16.2病例/100,000例），并且该国的某些地区受到了不成比例的影响。该项目旨在检查地理区域的独特环境和生态组成选择特定的肠道沙门氏菌血清，并影响人类疾病模式。这项工作将阐明负责沙门氏菌分布和人类疾病模式的重要生态因素，同时提供了一种创新的方法来帮助了解环境在人类肠道疾病中的作用。

项目成果

Diversity and Persistence of Salmonella enterica Strains in Rural Landscapes in the Southeastern United States.

美国东南部乡村地区肠道沙门氏菌菌株的多样性和持久性。

• DOI: 10.1371/journal.pone.0128937
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Maurer,JohnJ;Martin,Gordon;Hernandez,Sonia;Cheng,Ying;Gerner-Smidt,Peter;Hise,KelleyB;TobinD'Angelo,Melissa;Cole,Dana;Sanchez,Susan;Madden,Marguerite;Valeika,Steven;Presotto,Andrea;Lipp,ErinK
• 通讯作者: Lipp,ErinK