Neural Control of Grasping

抓取的神经控制

基本信息

  • 批准号:
    7494478
  • 负责人:
  • 金额:
    $ 24.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-04-01 至 2012-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Important features of the kinetics and kinematics of human object grasping and manipulation have been characterized, providing significant insight into how the Central Nervous System controls the hand. However, the underlying neural mechanisms that regulate the activity of multiple hand muscles are not yet well understood. This gap in our understanding of hand control has significant clinical implications for rehabilitation of hand function following neurological injury such as stroke. In our previous work we focused on correlated neural input to hand muscles to quantify the neural bases of force coordination during object grasping. We found that correlated neural input is distributed in a muscle-pair specific fashion, i.e., the neural coupling between certain muscle pairs is stronger than that between other muscle pairs. However, within this distribution, the strength of neural coupling of given muscle pairs could be modulated to task conditions. Yet, these results were obtained from a relatively small number of muscles and limited range of task conditions (grip type and object center of mass). The aim of the present study is to determine the neural mechanisms underlying a crucial aspect of hand control: the modulation of digit force direction. To attain this objective we will quantify the modulation of (a) EMG amplitude and (b) correlated neural input (coherence) of all muscles of the thumb, index and middle fingers as a function of digit force direction. Our working hypotheses are that (1) a force-direction dependent modulation of coherence between two muscles will occur as the relative force contribution of a given muscle to the modulation of fingertip force direction changes and (2) coherence modulation will occur within an invariant distribution of correlated neural input among hand muscle pairs. These hypotheses will be tested through one-digit force production tasks and multi-digit grasping tasks (Aim#1 and #2, respectively). The outcomes of our experiments will establish how motor commands controlling groups of hand muscles are modulated as a function of force direction and task constraints. Our data are expected to improve our understanding of the control of prehension, specifically the principles underlying fundamental mechanisms of synergistic control of hand muscles for object grasping and manipulation. Relevance to public health: We believe that this knowledge will be beneficial to rehabilitation and restoration of hand function as well as to the field of neuroprosthetics.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MARCO SANTELLO其他文献

MARCO SANTELLO的其他文献

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{{ truncateString('MARCO SANTELLO', 18)}}的其他基金

Coordination of human grasp and manipulation forces
人类抓握力和操纵力的协调
  • 批准号:
    10593716
  • 财政年份:
    2023
  • 资助金额:
    $ 24.96万
  • 项目类别:
Toward use of the synergy-based SoftHand Pro for activities of daily living by transradial amputees: A multi-site clinical trial
针对经桡动脉截肢者使用基于协同作用的 SoftHand Pro 进行日常生活活动:一项多中心临床试验
  • 批准号:
    10468739
  • 财政年份:
    2021
  • 资助金额:
    $ 24.96万
  • 项目类别:
Toward use of the synergy-based SoftHand Pro for activities of daily living by transradial amputees: A multi-site clinical trial
针对经桡动脉截肢者使用基于协同作用的 SoftHand Pro 进行日常生活活动:一项多中心临床试验
  • 批准号:
    10212104
  • 财政年份:
    2021
  • 资助金额:
    $ 24.96万
  • 项目类别:
Toward use of the synergy-based SoftHand Pro for activities of daily living by transradial amputees: A multi-site clinical trial
针对经桡动脉截肢者使用基于协同作用的 SoftHand Pro 进行日常生活活动:一项多中心临床试验
  • 批准号:
    10684785
  • 财政年份:
    2021
  • 资助金额:
    $ 24.96万
  • 项目类别:
Soft Synergy-Based Artificial Hand for Prosthetic Applications
用于假肢应用的基于软协同的假手
  • 批准号:
    8919829
  • 财政年份:
    2014
  • 资助金额:
    $ 24.96万
  • 项目类别:
Soft Synergy-Based Artificial Hand for Prosthetic Applications
用于假肢应用的基于软协同的假手
  • 批准号:
    8779291
  • 财政年份:
    2014
  • 资助金额:
    $ 24.96万
  • 项目类别:
Sensorimotor integration underlying hand control in Carpal Tunnel Syndrome
腕管综合症中手部控制的感觉运动整合
  • 批准号:
    7523938
  • 财政年份:
    2008
  • 资助金额:
    $ 24.96万
  • 项目类别:
Sensorimotor integration underlying hand control in Carpal Tunnel Syndrome
腕管综合症中手部控制的感觉运动整合
  • 批准号:
    7911721
  • 财政年份:
    2008
  • 资助金额:
    $ 24.96万
  • 项目类别:
Sensorimotor integration underlying hand control in Carpal Tunnel Syndrome
腕管综合症中手部控制的感觉运动整合
  • 批准号:
    7695025
  • 财政年份:
    2008
  • 资助金额:
    $ 24.96万
  • 项目类别:
Sensorimotor integration underlying hand control in Carpal Tunnel Syndrome
腕管综合症中手部控制的感觉运动整合
  • 批准号:
    8118500
  • 财政年份:
    2008
  • 资助金额:
    $ 24.96万
  • 项目类别:

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