Gene-Environment Interplay and Alcohol Use among Racially-Ethnically Diverse Youth: A Developmentally and Culturally Informed Approach

种族-民族多元化青年中的基因-环境相互作用和酒精使用：一种发展和文化知情的方法

• 批准号: 10779197
• 负责人: Jinni Su
• 金额: $ 33.33万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10779197
• 关键词: 10 year old; Acceleration; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohols; American; Behavior; Behavioral Genetics; Black race; Brain; Buffers; Cause of Death; Child; Child Health; Child Rearing; Childhood; Complex; Data; Development; Disease; Environment; Environmental Risk Factor; Equation; Etiology; European; European ancestry; Genes; Genetic; Genetic Risk; Health Disparities Research; Hispanic; Human; Impulsivity; Individual; Intervention; Latinx; Link; Mediating; Mission; Modeling; Outcome; Pathway interactions; Polygenic Traits; Population; Population Heterogeneity; Prevention; Prevention program; Process; Public Health; Research; Risk; Risk Factors; Role; Sampling; Science; Sex Differences; Shapes; Stressful Event; Survival Analysis; Symptoms; Temperament; Testing; Twin Multiple Birth; United States; United States National Institutes of Health; Youth; alcohol risk; alcohol use disorder; alcohol use initiation; cognitive development; contextual factors; cultural values; deter alcohol use; early alcohol use; ethnic diversity; ethnic minority population; gene environment interaction; genome-wide; genomic data; health disparity; high risk; insight; intervention program; peer; perceived discrimination; person centered; phenotypic data; prospective; protective factors; racial discrimination; racial diversity; racial minority population; societal costs; substance use; trait; underage drinking

PROJECT SUMMARY/ABSTRACT Alcohol is the most widely used substance and the third-leading preventable cause of death in the United States. Initiation of alcohol use typically occurs in adolescence, and early onset alcohol use (< age 15) has been associated with prolonged negative outcomes such as increased risk for AUD. The development of alcohol use and AUD is influenced by genetic and environmental factors, and the complex interactions among them (i.e., gene-environment interaction or GE). Yet, the majority of genetic and GE research has been 1) conducted with populations of European ancestry, and 2) focused on alcohol outcomes among individuals who have already initiated alcohol use or developed AUD. Thus, there is limited understanding of GE processes in racially-ethnically diverse populations, and how genetic risk manifests earlier in development in order to inform early prevention and intervention efforts. Furthermore, despite culture being an important context that shapes human behavior, cultural risk and protective factors have been largely overlooked in GE research. We seek to advance the understanding of etiology of alcohol use and AUD among racially-ethnically diverse populations by taking a developmentally and culturally informed approach to study GE processes. This project draws data from the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which includes rich genomic and phenotypic data from a longitudinal sample (N = 11,875; 52.1% White, 15.0% Black, and 20.3% Hispanic/Latinx) of racially-ethnically diverse children from late childhood (9-10 years old) through adolescence. The project examines three research aims. First, we will characterize polygenic influences on adolescent alcohol use among racially-ethnically diverse youth. Using a genome-wide polygenic score (PRS) approach, we will examine the effects of multiple adult and child-based PRS for alcohol and related traits (e.g., externalizing, internalizing symptoms) on timing of progression through the stages (e.g., experimentation, initiation, regular use, and problematic use), and trajectories of alcohol use from late childhood to adolescence. Second, we will examine the role of multiple childhood precursors (i.e., impulsivity, externalizing, and internalizing symptoms) in mediating polygenic influences on alcohol use. Finally, we will investigate the role of cultural-contextual risk and protective factors (i.e., parenting, peer deviance, stressful life events, racial discrimination experiences, familism cultural value) in moderating genetic influences on childhood precursors and adolescent alcohol use. We will explore how the associations of genetic, cultural-contextual factors, childhood precursors, and alcohol use change from late childhood to adolescence by examining age and developmental differences, and exploring differences by sex and pubertal status. Findings will advance alcohol and health disparities sciences by elucidating developmental and environmental mechanisms linking genetic risk to alcohol use among racially-ethnically diverse adolescents, providing critical insights for alcohol use prevention and intervention programs, including who is most at risk, what to target, and when to intervene.

项目概要/摘要 酒精是美国使用最广泛的物质，也是第三大可预防的死亡原因 开始饮酒通常发生在青春期，并且早期开始饮酒（< 15 岁）。 与长期的负面结果有关，例如澳元风险增加。 饮酒和 AUD 受到遗传和环境因素的影响，并且这些因素之间存在复杂的相互作用 它们（即基因-环境相互作用或 GE）然而，大多数遗传和 GE 研究都是 1）。 对欧洲血统人群进行的研究，以及 2) 重点关注以下人群的酒精结果： 已经开始饮酒或开发了 AUD，因此，对 GE 过程的了解有限。 种族多样化的人群，以及遗传风险如何在发育早期表现出来，以便提供信息 早期预防和干预工作。甚至，尽管文化是塑造文化的重要背景 我们力求在 GE 研究中很大程度上忽视人类行为、文化风险和保护因素。 对不同种族人群中饮酒和 AUD 的病因学的理解 该项目通过采用发展和文化方面的方法来研究 GE 流程。 来自正在进行的青少年大脑和认知发展（ABCD）研究，其中包括丰富的基因组 和来自纵向样本的表型数据（N = 11,875；52.1% 白人，15.0% 黑人，20.3% 西班牙裔/拉丁裔）的种族多元化儿童，从童年晚期（9-10 岁）到 该项目研究了三个研究目标，首先，我们将描述多基因对青春期的影响。 使用全基因组多基因评分（PRS）研究不同种族青少年的青少年酒精使用情况。 方法，我们将研究多种基于成人和儿童的 PRS 对酒精和相关特征（例如， 外化，内化症状）在各个阶段进展的时间（例如，实验， 开始、经常使用和有问题的使用）以及从儿童晚期到青春期的饮酒轨迹。 其次，我们将研究多种童年前兆的作用（即冲动、外化和 最后，我们将研究酒精使用的多基因影响的作用。 文化背景风险和保护因素（即养育方式、同伴偏差、压力生活事件、种族 歧视经历、家庭主义文化价值观）在调节遗传对儿童前身的影响方面 我们将探讨遗传、文化背景因素之间的关联。 通过检查年龄和年龄，儿童期前兆以及从童年晚期到青春期的酒精使用变化 发育差异，以及探索性别和青春期状态的差异将促进酒精的发展。 通过阐明将遗传联系起来的发育和环境机制来研究和健康差异科学 不同种族青少年的饮酒风险，为饮酒提供重要见解 预防和干预计划，包括谁的风险最大、目标是什么以及何时进行干预。