Core Center for Clinical Research at Northwestern University

西北大学临床研究核心中心

• 批准号: 10708051
• 负责人: Leena Sharma
• 金额: $ 78.64万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708051
• 关键词: Abbreviations; Acceleration; Accelerometer; Area; Attention; Behavioral; Behavioral Sciences; Bioinformatics; Budgets; Clinical; Clinical Informatics; Clinical Research; Collaborations; Communication; Communities; Community Outreach; Consult; Data; Database Management Systems; Databases; Development; Disease; Educational Activities; Ensure; Environment; Epidemiology; Equity; Evaluation; Feedback; Fostering; Foundations; Funding; Genomics; Goals; Grant; Health; Individual; Infrastructure; Institution; Intervention; Knowledge; Lead; Leadership; Life; Life Style; Manuscripts; Medical; Mental Health; Methodology; Mission; Motor; Musculoskeletal; Neighborhoods; Nutritional Science; Operations Research; Outcome; Outcome Assessment; Outcome Measure; Pathway interactions; Patient Self-Report; Performance; Persons; Physical activity; Physical assessment; Physiological; Policy Analysis; Positioning Attribute; Prevention; Prevention strategy; Procedures; Productivity; Recommendation; Registries; Rehabilitation therapy; Research; Research Design; Research Personnel; Resource Sharing; Resources; Risk; Science; Scientist; Sensory; Sleep; Specialist; Statistical Data Interpretation; Structure; Symptoms; Technology; Training; Universities; Vision; Work; clinical center; clinical development; cognitive function; cohort; community engaged research; community engagement; cost effectiveness; data management; data sharing; data streams; design; economic evaluation; education research; empowerment; experience; handheld mobile device; health equity; improved; innovation; member; operation; performance based measurement; person centered; personalized approach; portability; pragmatic study; preventive intervention; programs; prospective; psychologic; satisfaction; sedentary lifestyle; sensor; social; social health determinants; synergism; technological innovation; therapy development; wearable sensor technology; web based interface

The overarching goal of the Northwestern University (NU) CCCR is to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development through lifestyle, behavioral, medical, and rehabilitative solutions, built on a foundation of person-centered assessment in daily life and community engagement. Our overall aims are to: 1) accelerate and enhance funded research, by increasing stakeholder engagement, efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact; 2) organize and catalyze all relevant research at NU, applying a health equity lens, adding value, and moving it forward in a way that would otherwise not be feasible; 3) promote new research within our mission areas, by expanding the Research Community working in these areas and by expanding research fields within the mission. We will organize our resources into Cores but function as an integrated unit. Methodologic Core aims are: 1) provide expertise in study design, methodology, outcomes, and analysis planning; work with the Community Advisory Board and Resource Core to assist design that incorporates personal and community perspectives; integrate, as needed, input on adaptive and pragmatic study design, epidemiology, behavioral science, nutritional science, economic evaluation, policy analysis, genomics, bioinformatics, and clinical informatics; 2) facilitate use of existing databases and registries; 3) promote safe and responsible data management; 4) assist users in statistical analyses that maximize the potential of study data; and 5) enhance the training environment. Resource Core, Community Engaged Assessment and Intervention Science and Technology in Daily Life, aims are: 1) create and sustain interaction between stakeholders and research teams through project stages: a) build pathways for community?academic exchange to increase research value for improving health and equity by refining ideas and planning in partnership; b) build capacity for community-engaged research; 2) help teams design research that integrates personal and community perspectives; refine research questions, study design, assessment plan, intervention comparators and intervention procedures, and assist with budget planning, with the Methodologic Core; get stakeholder input on variables and outcomes and collaboratively develop assessment plans that can include: social determinants of health; accelerometry to assess physical activity, sedentary behavior, and sleep; mobile and sensor-based applications that identify behavioral markers; and wearable biosensors to predict physiological and psychological states; 3) help teams operationalize their research and create dissemination plans. Because our CCCR is centered on the goal to improve how persons feel and function in daily life, focuses on community and personal experience, and builds upon the wearable and portable technology revolution, we are positioned to have substantial impact on work within and beyond NU.

西北大学（NU）CCCR的总体目标是促进尖端的临床研究 旨在预防或控制风湿性和肌肉骨骼条件以及与之相关的不良预后 他们。尽管我们将提供广泛的支持，但我们将特别寻求推动这一主题：预防策略和 通过生活方式，行为，医疗和康复解决方案开发干预，建立在 以人为中心的日常生活和社区参与的基础。我们的总体目标是： 1）通过提高利益相关者的互动，效率，严格，加速并增强资助的研究 协作，成本效益，生产力和影响； 2）在组织和催化所有相关研究 NU，应用健康权益镜头，增加价值，并以否则不会是的方式向前推动它 可行的; 3）通过扩大研究社区的工作，促进我们的任务领域内的新研究 这些领域以及通过扩大任务中的研究领域。我们将将我们的资源组织到核心中，但是 充当集成单元。方法论核心的目的是：1）提供研究设计，方法论的专业知识， 结果和分析计划；与社区咨询委员会和资源核心合作以协助 包含个人和社区观点的设计；根据需要集成自适应和 务实的研究设计，流行病学，行为科学，营养科学，经济评估，政策 分析，基因组学，生物信息学和临床信息学； 2）促进现有数据库的使用 登记； 3）促进安全有负责任的数据管理； 4）协助用户进行统计分析 最大化研究数据的潜力； 5）增强培训环境。资源核心，社区 敬业的评估和干预科学技术在日常生活中，目的是：1）创建和维持 通过项目阶段，利益相关者与研究团队之间的互动：a）建立途径 社区？学术交流，通过提炼想法来提高研究价值以提高健康和公平 并合作计划； b）建立社区参与研究的能力； 2）帮助团队设计研究 整合了个人和社区观点；完善研究问题，研究设计，评估 计划，干预比较者和干预程序，并协助预算计划， 方法论核心；获取利益相关者对变量和结果的意见，并协作进行评估 可以包括：健康的社会决定因素；加速测定法评估体育锻炼，久坐 行为和睡眠；识别行为标记的基于移动和传感器的应用程序；可穿戴 预测生理和心理状态的生物传感器； 3）帮助团队运作他们的研究和 创建传播计划。因为我们的CCCR集中在改善人的感受和 在日常生活中发挥作用，专注于社区和个人经验，并建立在可穿戴的基础上 便携式技术革命，我们有权对NU内外的工作产生重大影响。

项目成果

Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis.

• DOI: 10.1007/s00330-017-5140-1
• 发表时间: 2018-05
• 期刊: European radiology
• 影响因子: 5.9
• 作者: Roth M;Emmanuel K;Wirth W;Kwoh CK;Hunter DJ;Eckstein F
• 通讯作者: Eckstein F

Wearable Technology and Physical Activity in Chronic Disease: Opportunities and Challenges.

• DOI: 10.1016/j.amepre.2017.08.015
• 发表时间: 2018-01
• 期刊: American journal of preventive medicine
• 影响因子: 5.5
• 作者: Phillips SM;Cadmus-Bertram L;Rosenberg D;Buman MP;Lynch BM
• 通讯作者: Lynch BM

Evaluation of structured data from electronic health records to identify clinical classification criteria attributes for systemic lupus erythematosus.

• DOI: 10.1136/lupus-2021-000488
• 发表时间: 2021-04
• 期刊: Lupus science & medicine
• 影响因子: 3.9
• 作者: Walunas TL;Ghosh AS;Pacheco JA;Mitrovic V;Wu A;Jackson KL;Schusler R;Chung A;Erickson D;Mancera-Cuevas K;Luo Y;Kho AN;Ramsey-Goldman R
• 通讯作者: Ramsey-Goldman R

One report, multiple aims: orthopedic surgeons vary how they use patient-reported outcomes with patients.

• DOI: 10.1007/s11136-022-03251-7
• 发表时间: 2023-03
• 期刊: QUALITY OF LIFE RESEARCH
• 影响因子: 3.5
• 作者: Lavallee, Danielle C.;Rothrock, Nan E.;Chen, Antonia F.;Franklin, Patricia D.
• 通讯作者: Franklin, Patricia D.

Reallocating time spent in sleep, sedentary behavior and physical activity and its association with pain: a pilot sleep study from the Osteoarthritis Initiative.

重新分配睡眠、久坐行为和体力活动的时间及其与疼痛的关系：骨关节炎倡议的一项试点睡眠研究。

• DOI: 10.1016/j.joca.2018.07.002
• 发表时间: 2018
• 期刊: Osteoarthritis and cartilage
• 影响因子: 7
• 作者: Song,J;Dunlop,DD;Semanik,PA;Chang,AH;Lee,YC;Gilbert,AL;Jackson,RD;Chang,RW;Lee,J
• 通讯作者: Lee,J