Pelvic Floor Disorders Network Clinical Site

盆底疾病网络临床网站

• 批准号: 10891248
• 负责人: KIMBERLY Sue KENTON
• 金额: $ 27.5万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891248
• 关键词: Absence of pain sensation; Acceleration; Accelerometer; Adherence; Adult; Anatomy; Back; Bladder; Caring; Centers for Disease Control and Prevention (U.S.); Clinical Trials; Collaborations; Counseling; Data; Distress; Ensure; Environment; Equipment and supply inventories; Equity; Exercise; Exercise Physiology; Exercise Tolerance; Family; Frequencies; Future; Goals; Health; Hospitals; Infrastructure; Lead; Life Style; Masks; Measures; Medicine; Moderate Exercise; Muscle; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Needles; Operative Surgical Procedures; Outcome; Patient Outcomes Assessments; Patients; Pelvic Floor Disorders; Pelvic floor structure; Pelvis; Perioperative; Perioperative Care; Positioning Attribute; Postoperative Period; Productivity; Protocols documentation; Ptosis; Questionnaires; Randomized; Randomized, Controlled Trials; Recommendation; Recovery; Recurrence; Reporting; Research; Research Personnel; Resolution; Resources; Scientist; Speed; Surgeon; Symptoms; Time; Urinary Incontinence; Woman; arm; career; clinical research site; compliance behavior; deconditioning; design; exercise intensity; exercise program; exercise regimen; experience; improved; innovation; minimally invasive; multidisciplinary; opioid sparing; patient population; pelvic organ prolapse; postoperative recovery; prevent; randomized trial; recruit; response; restricted physical activity

Project Abstract This application to be a Pelvic Floor Disorders Network Clinical Site contains both an innovative randomized controlled trial and comprehensive description of Northwestern Medicine’s unique strengths, as a team and environment, to contribute to all PFDN trials. Our concept proposal draws on the collective experience of our team in exercise physiology, perioperative optimization, and postoperative recovery. The proposal describes a randomized controlled trial of prescriptive early exercise following prolapse surgery to reduce deconditioning and improve recovery without any negative impact on pelvic floor outcomes. Our proposed study will go beyond existent research and be the first to implement and quantitatively evaluate (using accelerometer data) a postoperative exercise regimen and its effects on recovery and pelvic floor symptoms. In addition, our proposal highlights the strengths of our large, high volume, multi- disciplinary team, which draws from a diverse patient population across several regional hospitals to ensure equity and inclusion within PFDN clinical trials. We can also leverage our resources and collaborations as part of two NIDDK cooperative networks related to urinary incontinence and bladder health to advance the PFDN’s goals. The NM team is a nationally recognized group of collaborative, productive, and established investigators well poised to lead the design, implementation, analysis and dissemination of this multicenter RCT as well as participate in and lead additional studies within the PFDN.

项目摘要 该应用程序是骨盆底疾病网络临床网站既包含创新的 随机对照试验和西北医学独特的全面描述 作为团队和环境的优势，为所有PFDN试验做出贡献。我们的概念提议借鉴了 我们团队在运动生理，定期优化和术后恢复方面的集体经验。 该提案描述了脱垂手术后的规范性早期运动的随机对照试验 减少对根源并改善恢复，而不会对骨盆底结果产生任何负面影响。我们的 拟议的研究将超越现有研究，并成为第一个实施和定量的研究 评估（使用加速度计数据）术后运动方案及其对恢复和的影响 骨盆底症状。此外，我们的提议强调了我们大型，大量，多数的优势 纪律团队，从几家区域医院的患者人群中吸取了纪律处分，以确保 PFDN临床试验中的公平性和包容性。我们还可以利用我们的资源和合作作为一部分 与尿失禁和膀胱健康有关的两个NIDDK合作网络，以促进PFDN 目标。 NM团队是一个全国认可的合作，富有成效和建立的团体 调查人员有毒化的领导，实施，分析和传播此 多中心RCT以及参与PFDN中的其他研究。