Pelvic Floor Disorders Network Clinical Site

盆底疾病网络临床网站

• 批准号: 10891248
• 负责人: KIMBERLY Sue KENTON
• 金额: $ 27.5万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891248
• 关键词: Absence of pain sensation; Acceleration; Accelerometer; Adherence; Adult; Anatomy; Back; Bladder; Caring; Centers for Disease Control and Prevention (U.S.); Clinical Trials; Collaborations; Counseling; Data; Distress; Ensure; Environment; Equipment and supply inventories; Equity; Exercise; Exercise Physiology; Exercise Tolerance; Family; Frequencies; Future; Goals; Health; Hospitals; Infrastructure; Lead; Life Style; Masks; Measures; Medicine; Moderate Exercise; Muscle; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Needles; Operative Surgical Procedures; Outcome; Patient Outcomes Assessments; Patients; Pelvic Floor Disorders; Pelvic floor structure; Pelvis; Perioperative; Perioperative Care; Positioning Attribute; Postoperative Period; Productivity; Protocols documentation; Ptosis; Questionnaires; Randomized; Randomized, Controlled Trials; Recommendation; Recovery; Recurrence; Reporting; Research; Research Personnel; Resolution; Resources; Scientist; Speed; Surgeon; Symptoms; Time; Urinary Incontinence; Woman; arm; career; clinical research site; compliance behavior; deconditioning; design; exercise intensity; exercise program; exercise regimen; experience; improved; innovation; minimally invasive; multidisciplinary; opioid sparing; patient population; pelvic organ prolapse; postoperative recovery; prevent; randomized trial; recruit; response; restricted physical activity

Project Abstract This application to be a Pelvic Floor Disorders Network Clinical Site contains both an innovative randomized controlled trial and comprehensive description of Northwestern Medicine’s unique strengths, as a team and environment, to contribute to all PFDN trials. Our concept proposal draws on the collective experience of our team in exercise physiology, perioperative optimization, and postoperative recovery. The proposal describes a randomized controlled trial of prescriptive early exercise following prolapse surgery to reduce deconditioning and improve recovery without any negative impact on pelvic floor outcomes. Our proposed study will go beyond existent research and be the first to implement and quantitatively evaluate (using accelerometer data) a postoperative exercise regimen and its effects on recovery and pelvic floor symptoms. In addition, our proposal highlights the strengths of our large, high volume, multi- disciplinary team, which draws from a diverse patient population across several regional hospitals to ensure equity and inclusion within PFDN clinical trials. We can also leverage our resources and collaborations as part of two NIDDK cooperative networks related to urinary incontinence and bladder health to advance the PFDN’s goals. The NM team is a nationally recognized group of collaborative, productive, and established investigators well poised to lead the design, implementation, analysis and dissemination of this multicenter RCT as well as participate in and lead additional studies within the PFDN.

项目摘要 该应用程序将成为盆底疾病网络临床站点，包含创新的 随机对照试验全面描述西北医学的独特之处 我们的概念提案借鉴了团队和环境的优势，为所有 PFDN 试验做出贡献。 我们团队在运动生理学、围手术期优化和术后恢复方面的集体经验。 该提案描述了一项在脱垂手术后进行规定性早期锻炼的随机对照试验，以 减少失调并改善恢复，而不会对盆底结果产生任何负面影响。 拟议的研究将超越存在研究，并成为第一个实施和定量的研究 评估（使用加速度计数据）术后方案锻炼及其对恢复和恢复的影响 此外，我们的提案强调了我们的大、高容量、多的优势。 纪律小组，该小组来自多家地区医院的不同患者群体，以确保 PFDN 临床试验中的公平性和包容性我们还可以利用我们的资源和合作作为一部分。 两个与尿失禁和膀胱健康相关的 NIDDK 合作网络，以推进 PFDN 的发展 NM 团队是一个全国公认的协作、富有成效且成熟的团队。 研究人员已准备好领导这一研究的设计、实施、分析和传播 多中心 RCT 以及参与和领导 PFDN 内的其他研究。