Function of the Urethra in Continent Women

大陆女性尿道的功能

基本信息

批准号：
7488320
负责人：
KIMBERLY Sue KENTON
金额：
$ 9.9万
依托单位：
LOYOLA UNIVERSITY CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2010-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7488320
关键词：
Affect Afferent Neurons African American Age American Bladder Bladder Control Caucasians Caucasoid Race Cell Nucleus Clinical Clinical Research Closure Condition Contracts Country Data Development Distal Doctor of Medicine Economics Elderly Electrodiagnosis Electromyography Etiology Fiber Follow-Up Studies Funding Goals Incontinence Injury Liquid substance Master of Science Master&apos s Degree Mentors Mentorship Methodology Michigan Motor Motor Neurons Muscle Muscle function National Institute of Child Health and Human Development Needles Neurotransmitters Norepinephrine Operative Surgical Procedures Organ Outcome Pelvic Floor Disorders Pelvic floor dysfunction Pelvis Perception Personal Satisfaction Persons Population Prevalence Principal Investigator Ptosis Purpose Race Range Reporting Request for Applications Research Research Design Research Personnel Research Project Grants Serotonin Signal Transduction Smooth Muscle Sphincter Stress Stress Urinary Incontinence Surgeon Testing Thinking Time Training United States Universities Urethra Urethral sphincter Urinary Incontinence Urine Woman Work autonomic nerve career cost design innovation interest levator ani muscle nerve supply neuromuscular function next generation patient oriented patient oriented research pressure prevent programs repaired skills spinal reflex urinary bladder neck

项目摘要

DESCRIPTION (provided by applicant): This application requests funds for two purposes: 1) Career Development: The applicant plans to obtain a Master of Science degree in Clinical Research Design and Statistical Analysis from the University of Michigan. The career goals include short and long-term goals. Short-term goals include the obtaining the Master Degree and beginning an innovative well-designed patient-oriented research project under the mentorship of a highly productive clinical researcher. The long-term goals include developing into an independent patient-oriented researcher with expertise in electrodiagnosis and urethral function, enhancing research abilities with a better understanding of methodology and design, designing follow-up studies to prevent and treat neuromuscular injuries to the urethral sphincter, submission of an R01 to fund such studies, and developing research mentoring skills to begin training the next generation of patient-oriented clinical researchers. 2) Research Project: The specific aims of the research plan are: 1. To acquire high-quality neuromuscular signals from the urethra using concentric needle electromyography (EMG; with quantitative motor unit analysis) and current perception threshold testing to test the null hypothesis that there are no differences in urethral neuromuscular function in: i) Caucasian and African American women; ii) Continent and stress incontinent women; and iii) Continent nulliparous and parous women. 2. To establish quantitative parameters of urethral sphincter function in women of various races. Normative ranges will be calculated for EMG, current perception thresholds, and urethral pressures for Caucasian and African American women. These data can then be used by other centers as reference data.

描述（由申请人提供）：本申请请求资金用于两个目的： 1）职业发展：申请人计划获得密歇根大学临床研究设计和统计分析理学硕士学位。职业目标包括短期目标和长期目标。短期目标包括获得硕士学位，并在高产临床研究人员的指导下开始一项精心设计的、以患者为导向的创新研究项目。长期目标包括发展成为一名独立的、以患者为中心的、具有电诊断和尿道功能专业知识的研究人员，通过更好地理解方法和设计来提高研究能力，设计后续研究以预防和治疗尿道括约肌的神经肌肉损伤，提交 R01 来资助此类研究，并开发研究指导技能以开始培训下一代以患者为导向的临床研究人员。 2) 研究项目：该研究计划的具体目标是： 1. 使用同心针肌电图（EMG；定量运动单位分析）和电流感知阈值测试从尿道获取高质量的神经肌肉信号，以检验原假设：以下人群的尿道神经肌肉功能没有差异： i) 白种人和非裔美国女性； ii) 失禁和压力失禁的女性； iii) 大陆未产妇和已产妇女。 2. 建立不同种族女性尿道括约肌功能的定量参数。将计算白人和非裔美国女性的肌电图、当前感知阈值和尿道压力的标准范围。这些数据可以被其他中心用作参考数据。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

How Does the Urethra Respond to Bladder Filling in Continent and Incontinent Women?

DOI：
10.1097/spv.0000000000001125
发表时间：
2022-05-01
期刊：
Female pelvic medicine & reconstructive surgery
影响因子：
1.6
作者：
通讯作者：

Neuromuscular characterization of the urethra in continent women.

DOI：
10.1097/spv.0b013e31822dd012
发表时间：
2011-09
期刊：
Female pelvic medicine & reconstructive surgery
影响因子：
1.6
作者：
Kenton K;Mueller E;Brubaker L
通讯作者：
Brubaker L

Observations relating to urinary sensation during detrusor overactivity.

逼尿肌过度活动期间与排尿感觉相关的观察结果。

DOI：
10.1002/nau.20680
发表时间：
2009
期刊：
Neurourology and urodynamics
影响因子：
2
作者：
Lowenstein,Lior;Pham,Thythy;Abbasy,Shameem;Kenton,Kimberly;Brubaker,Linda;Mueller,ElizabethR;Shott,Susan;Vardi,Yoram;Gruenwald,Ilan;FitzGerald,MaryP
通讯作者：
FitzGerald,MaryP

Validation of a real-time urodynamic measure of urinary sensation.

尿感实时尿动力学测量的验证。

DOI：
10.1016/j.ajog.2008.02.023
发表时间：
2008
期刊：
American journal of obstetrics and gynecology
影响因子：
9.8
作者：
Lowenstein,Lior;FitzGerald,MaryP;Kenton,Kimberly;Brubaker,Linda;Gruenwald,Ilan;Papier,Irena;Durazo-Arvizu,RamonA;Elliot,Christina;Mueller,ElizabethR;Vardi,Yoram
通讯作者：
Vardi,Yoram

Neuromuscular urethral function and urethral urodynamic parameters between urgency and stress incontinence do not differ.

急迫性尿失禁和压力性尿失禁之间的神经肌肉尿道功能和尿道尿动力学参数没有差异。