Function of the Urethra in Continent Women

大陆女性尿道的功能

• 批准号: 6776829
• 负责人: KIMBERLY Sue KENTON
• 金额: $ 9.71万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6776829
• 关键词: adult human (21+); clinical research; electromyography; female; human subject; neuromuscular function; parity; patient oriented research; racial /ethnic difference; sensory thresholds; urethra; urinary incontinence; women' s health

DESCRIPTION (provided by applicant): This application requests funds for two purposes: 1) Career Development: The applicant plans to obtain a Master of Science degree in Clinical Research Design and Statistical Analysis from the University of Michigan. The career goals include short and long-term goals. Short-term goals include the obtaining the Master Degree and beginning an innovative well-designed patient-oriented research project under the mentorship of a highly productive clinical researcher. The long-term goals include developing into an independent patient-oriented researcher with expertise in electrodiagnosis and urethral function, enhancing research abilities with a better understanding of methodology and design, designing follow-up studies to prevent and treat neuromuscular injuries to the urethral sphincter, submission of an R01 to fund such studies, and developing research mentoring skills to begin training the next generation of patient-oriented clinical researchers. 2) Research Project: The specific aims of the research plan are: 1. To acquire high-quality neuromuscular signals from the urethra using concentric needle electromyography (EMG; with quantitative motor unit analysis) and current perception threshold testing to test the null hypothesis that there are no differences in urethral neuromuscular function in: i) Caucasian and African American women; ii) Continent and stress incontinent women; and iii) Continent nulliparous and parous women. 2. To establish quantitative parameters of urethral sphincter function in women of various races. Normative ranges will be calculated for EMG, current perception thresholds, and urethral pressures for Caucasian and African American women. These data can then be used by other centers as reference data.

描述（由申请人提供）：本申请要求有两个目的的资金： 1）职业发展：申请人计划获得密歇根大学临床研究设计和统计分析的理学硕士学位。职业目标包括短期和长期目标。 短期目标包括获得硕士学位，并在高产临床研究人员的指导下开始了创新的以患者为导向的研究项目。长期目标包括发展为具有电诊断和尿道功能专业知识的独立的以患者为导向的研究人员，增强研究能力，对方法论和设计有更好的理解，设计后续研究，以防止和治疗神经肌肉损伤，以促进尿道斜率的神经肌肉损伤，R01的提出R01的提出，以资助这些研究，并开始研究研究员，并开始培训研究员的研究员，以培训患者。 2）研究项目：研究计划的具体目的是：1。使用同心针肌电图（EMG；具有定量运动单位分析）和当前的感知阈值测试以测试null假设，即在尿素神经肌肉中没有差异，从而测试了尿素的神经肌肉症，以测试尿素神经肌肉的caucucian and Anivarian and Anivarian and Anivarian and Anivan Aniver Aniver Aniver Aniver Aniver Aniver Aniver Aniver Antoric Anorica; ii）大陆和压力失火妇女；和iii）大陆无效的妇女。 2。在各种种族的女性中建立尿道括约肌功能的定量参数。将计算出针对高加索和非裔美国人妇女的EMG，当前的看法阈值以及尿道压力的规范范围。然后，这些数据可以由其他中心用作参考数据。