Core Center for Clinical Research at Northwestern University

西北大学临床研究核心中心

• 批准号: 9413675
• 负责人: Leena Sharma
• 金额: $ 79万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9413675
• 关键词: Accelerometer; Area; Behavior Therapy; Behavioral; Behavioral Sciences; Bioinformatics; Biosensor; Clinical Informatics; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Consultations; Custom; Data; Data Analyses; Data Collection; Development; Discipline; Educational process of instructing; Educational workshop; Ensure; Environment; Epidemiology; Evaluation; Faculty; Fostering; Funding; Genomics; Goals; Health; Human; Individual; Information Technology; Institutes; Institution; Internet; Intervention; Kinesiology; Knowledge; Lead; Leadership; Life; Life Style; Measurement; Medical; Medicine; Mental Health; Mentors; Methodology; Methods; Mission; Modality; Monitor; Motor; Musculoskeletal; Nutritional Science; Operations Research; Outcome; Outcome Assessment; Patient Self-Report; Performance; Persons; Physical Medicine; Physical Rehabilitation; Physical activity; Physical therapy; Physiological; Positioning Attribute; Prevention; Prevention strategy; Preventive Intervention; Preventive Medicine; Productivity; Public Health; Rehabilitation therapy; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Risk; Role; Science; Scientist; Sensory; Services; Sleep; Social Sciences; Statistical Data Interpretation; Structure; Symptoms; Tablets; Target Populations; Technology; Training; Translational Research; Universities; Vision; Work; base; cognitive function; cost effectiveness; data management; data resource; design; economic evaluation; empowered; implementation science; improved; innovation; instrument; member; operation; person centered; physical conditioning; portability; programs; prospective; psychologic; satisfaction; sedentary lifestyle; sensor; social; synergism; technological innovation; therapy development

The overarching goal of the proposed Northwestern University (NU) Core Center for Clinical Research (CCCR) is to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development to create lifestyle, behavioral, medical, and rehabilitative solutions. Overall aims are: 1) accelerate and enhance funded research, by improving efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact; 2) catalyze and add value to all NU research relevant to our mission; and 3) promote new research, by expanding the community working in the areas of our mission and by expanding research fields within the mission. This CCCR is organized into Administrative, Methodologic, and Resource Cores. Methodologic Core aims include, to provide: data management support; expertise pertaining to research design, study conduct, outcome assessment, and data analysis; an enhanced training environment through focused services, collaboration, team science training; cutting-edge capabilities to meet ongoing and evolving needs of the Research Community regarding: a) statistical analysis, b) epidemiology, c) behavioral science, d) nutritional science, e) implementation science, f) economic evaluation, g) genomics/bioinformatics, and h) clinical informatics. The Resource Core, Assessment & Intervention Science & Technology in Daily Life, will integrate Sub-Cores (Person-Centered Outcomes Assessment and Technology; Accelerometer Measurement of Physical Activity, Sedentary Behavior and Sleep; and Behavioral Intervention Technologies), with these aims: design tailored multi-modal assessment and health interventions, incorporating real-world: a) self-report of social, physical, and mental health, symptoms, and life satisfaction, and performance-based assessment of motor, sensory, and cognitive function; b) accelerometry to assess physical activity, sedentary behavior, and sleep; and c) mobile, web, tablet, and sensor-based applications that identify real-world behavioral markers using GPS, activity logs, and wearable biosensors, to predict physiological and psychological states; and implement technology platforms that can deploy interventions and administer multi-modal assessment, integrating into the platform self-report, performance-based, and accelerometer assessment. Through our relationships – with Preventive Medicine, Physical Medicine and Rehabilitation, Medical Social Sciences, Physical Therapy and Human Movement Sciences, the Institute for Public Health and Medicine, and the NU Clinical and Translational Sciences Institute (CTSA) – this CCCR will draw on a diverse university community. In turn, our CCCR will create powerful and innovative resources. Because this CCCR a) is centered on the goal to improve how persons feel and function in their daily lives, b) builds upon the wearable and portable technology revolution, and c) integrates outstanding programs, it is well-positioned to have substantial impact within and beyond our institution.

拟议的西北大学（NU）临床研究中心（CCCR）的总体目标 是为了促进旨在预防或控制风湿和肌肉骨骼的尖端临床研究 条件和结果不佳。虽然我们将提供广泛的支持，但我们将特别 寻求推动这一主题：预防策略和干预发展以创造生活方式，行为， 医疗和康复解决方案。总体目的是：1）加速和增强研究， 提高效率，严格，协作，成本效益，生产力和影响； 2）催化并添加 对与我们的使命相关的所有NU研究的价值； 3）通过扩大社区来促进新研究 在我们的任务领域并扩大任务中的研究领域的工作。这个CCCR是 组织为行政，方法论和资源核心。方法论核心的目的包括：提供： 数据管理支持；与研究设计，研究行为，结果评估以及 数据分析；通过重点服务，协作，团队科学来增强培训环境 训练;满足研究界正在进行和不断发展的需求的尖端功能有关： a）统计分析，b）流行病学，c）行为科学，d）营养科学，e）实施科学， f）经济评估，g）基因组学/生物信息学和h）临床信息。资源核心， 评估与干预科学技术在日常生活中将整合子核（以人为本） 结果评估和技术；加速度计测量体育活动，久坐行为 和睡觉；和行为干预技术），以这些目的：设计量身定制的多模式 评估和健康干预措施，结合现实世界：a）社会，身体和精神的自我报告 健康，症状和生活满意度以及基于绩效的运动，感觉和认知评估 功能; b）评估体育活动，久坐行为和睡眠的加速度计； c）移动，网络， 平板电脑和基于传感器的应用程序，可使用GPS，活动日志和 可穿戴生物传感器，以预测生理和心理状态；并实施技术平台 这可以部署干预措施并管理多模式评估，并集成到平台自我报告中， 基于绩效和加速度计的评估。通过我们的关系 - 预防医学， 物理医学和康复，医学社会科学，物理疗法和人类运动 科学，公共卫生与医学研究所以及NU临床和转化科学研究所 （CTSA） - 此CCCR将借鉴潜水大学的社区。反过来，我们的CCCR将创造强大的 创新资源。因为此CCCR a）以改善人们的感觉和功能的目标为中心 在日常生活中，b）建立在可穿戴和便携式技术革命的基础上，c）综合 杰出的计划，它具有良好的态度，可以在我们机构内部和超越我们的机构内部产生重大影响。