Application of social cognitive theory to physical activity behavior among adults with Crohn's disease

社会认知理论在克罗恩病成人体力活动行为中的应用

• 批准号: 10745823
• 负责人: Whitney Neal
• 金额: $ 3.97万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-04 至 2025-12-03
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745823
• 关键词: Accelerometer; Adult; Affect; Age; Albumins; Area; Behavior; Behavioral; Biological; Biological Markers; C-reactive protein; CD6 antigen; Chronic; Chronic Disease; Clinical; Clinical Trials Design; Community Practice; Complex; Control Groups; Crohn' s disease; Development; Devices; Disease; Disease Outcome; Familiarity; Foundations; Future; General Population; Goals; Health Benefit; Health Care Costs; Health Promotion; Histologic; Individual; Inflammatory; Informal Social Control; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Leukocyte L1 Antigen Complex; Measures; Medical Records; Mentorship; Methodology; Mucous Membrane; Muscle function; Operative Surgical Procedures; Outcome; Participant; Patient Care; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physical activity; Physical assessment; Play; Population; Postoperative Period; Public Health; Questionnaires; Reporting; Research; Research Personnel; Research Proposals; Role; Sample Size; Sampling; Scientist; Self Assessment; Self Efficacy; Social support; Solid; Specificity; Statistical Methods; Surgeon; Testing; Therapeutic Effect; Training; Translating; Translational Research; Translations; Ulcerative Colitis; behavior change; cardiorespiratory fitness; career; clinical application; clinical practice; clinical remission; design; evidence base; exercise intervention; expectation; healing; improved; indexing; programs; psychosocial; responsible research conduct; sedentary; sedentary lifestyle; sex; skills; social cognitive theory; sound; therapy development; treatment program; Accelerometer; Adult; Affect; Age; Albumins; Area; Behavior; Behavioral; Biological; Biological Markers; C-reactive protein; CD6 antigen; Chronic; Chronic Disease; Clinical; Clinical Trials Design; Community Practice; Complex; Control Groups; Crohn' s disease; Development; Devices; Disease; Disease Outcome; Familiarity; Foundations; Future; General Population; Goals; Health Benefit; Health Care Costs; Health Promotion; Histologic; Individual; Inflammatory; Informal Social Control; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Leukocyte L1 Antigen Complex; Measures; Medical Records; Mentorship; Methodology; Mucous Membrane; Muscle function; Operative Surgical Procedures; Outcome; Participant; Patient Care; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physical activity; Physical assessment; Play; Population; Postoperative Period; Public Health; Questionnaires; Reporting; Research; Research Personnel; Research Proposals; Role; Sample Size; Sampling; Scientist; Self Assessment; Self Efficacy; Social support; Solid; Specificity; Statistical Methods; Surgeon; Testing; Therapeutic Effect; Training; Translating; Translational Research; Translations; Ulcerative Colitis; behavior change; cardiorespiratory fitness; career; clinical application; clinical practice; clinical remission; design; evidence base; exercise intervention; expectation; healing; improved; indexing; programs; psychosocial; responsible research conduct; sedentary; sedentary lifestyle; sex; skills; social cognitive theory; sound; therapy development; treatment program

PROJECT SUMMARY/ABSTRACT Crohn’s disease (CD), which affects over 500,000 individuals with CD in the US, is a chronic and uniquely challenging condition that requires lifelong medications, major surgeries, and health promotion. Physical activity (PA) is an essential component of many chronic disease and surgical treatment programs, but the potential benefits of PA in CD are poorly understood as there has been a paucity of research in CD. Identifying factors that influence PA participation and the extent and intensity regular PA has a therapeutic effect (i.e., inflammatory biomarkers, mucosal healing) on disease activity in CD is important for developing effective PA interventions that can be translated to practice. Therefore, the primary objective of this research proposal is to examine the complex behavioral and biological correlates of PA in CD. This project seeks to compare PA rates between adults with CD and healthy controls (Aim 1) and examine the psychosocial and clinical influences on self-report and device-measured PA (Aims 2 and 3) in CD. The central hypothesis is that adults with CD who report lower levels of self-efficacy engage in less device-measured PA and more sedentary behavior than the general population, and that the relationship between PA and disease outcomes varies by both volume and pattern of PA behavior and the aspect of disease activity measured. The public health significance of this study lies in its potential to develop an improved, theoretically sound understanding of PA behavior in CD and the relationship between PA and disease activity. These findings could potentially result in better designed, more effective PA programs for adults with CD that ultimately have the potential to reduce healthcare costs associated with adverse postoperative outcomes. My ultimate career goal is to lead a collaborative research team that bridges the gap between evidence-based PA interventions and the translation of this evidence into clinical and community practice in the context of CD. To better prepare myself for a career as an independent investigator, I am seeking training in 4 major areas: 1) rigorous research in the CD field, including familiarity with CD clinical patient care; 2) multidisciplinary collaboration with clinicians and scientists; 3) translational research, including clinical trial design, statistical methods, and interpretation of results for clinical application and future intervention development; and 4) professional development, including principles of scientific integrity and responsible conduct of research. Training in these areas is integral to completing the research aims and providing me with a solid foundation for a successful career as an independent researcher.

项目摘要/摘要 在美国影响超过500,000名CD的人的克罗恩病（CD）是一种慢性且独特的 具有挑战性的状况，需要终身药物，主要手术和促进健康。体育锻炼 （PA）是许多慢性疾病和手术治疗计划的重要组成部分，但潜力 由于CD的研究很少，因此PA在CD中的好处对CD的理解很差。识别因素 这会影响PA的参与以及常规PA的程度和强度具有治疗作用（即炎症 生物标志物，粘膜愈合）对CD疾病活动的粘膜愈合对于制定有效的PA干预很重要 可以将其转化为实践。因此，该研究建议的主要目的是检查 CD中PA的复杂行为和生物学相关性。该项目旨在比较PA的价格 具有CD和健康对照的成年人（AIM 1）并检查对自我报告的社会心理和临床影响 和CD中的设备测量PA（目标2和3）。中心假设是有CD的成年人报告较低 比一般的自我效能感的水平具有较少的设备测量PA和更久坐的行为 人口，以及PA与疾病结局之间的关系。 PA行为和疾病活动的方面测量。这项研究的公共卫生意义在于 有可能对CD中PA行为的改进，理论上的声音理解和关系 在PA和疾病活动之间。这些发现可能会导致设计更好，更有效的PA 针对CD的成人计划，最终有可能降低与广告相关的医疗保健费用 术后结果。我的最终职业目标是领导一个弥合差距的协作研究团队 在基于证据的PA干预与将该证据转化为临床和社区之间 在CD的背景下进行练习。为了更好地为作为独立调查员的职业做好准备，我正在寻找 在4个主要领域进行培训：1）CD领域的严格研究，包括熟悉CD临床患者护理； 2）与临床医生和科学家的多学科合作； 3）翻译研究，包括临床试验 设计，统计方法和临床应用结果和未来干预结果的解释 发展; 4）专业发展，包括科学诚信原则和负责任的行为 研究。在这些领域的培训是完成研究目标不可或缺的一部分，并为我提供了坚实的 成功地成为独立研究人员的职业生涯的基础。