The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function

日常世界的神经科学——一种用于连续测量大脑功能的新型可穿戴系统

• 批准号: 10631228
• 负责人: David A Boas
• 金额: $ 118.77万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631228
• 关键词: Acceleration; Adult; Algorithms; Area; Behavior; Behavioral; Blood Vessels; Brain; Brain imaging; Clinical; Cognition; Communication; Complement; Complex; Computer Vision Systems; Data; Development; Devices; Disease; Electrodes; Engineering; Environment; Failure; Foundations; Functional Magnetic Resonance Imaging; Future; Glass; Goals; Hour; Human; Hybrids; Imaging Device; Individual; Investigation; Laboratories; Link; Maps; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Motion; Movement; Neurologic; Neurons; Neurosciences; Noise; Parkinson Disease; Pattern; Perception; Phase; Physiological; Population; Positioning Attribute; Predisposition; Rehabilitation therapy; Research; Research Personnel; Sampling; Scientist; Signal Transduction; Social Interaction; Speech; Stroke; Support System; System; Techniques; Technology; Text; Time; Translations; Walking; Work; density; design; experimental study; frontier; functional near infrared spectroscopy; hemodynamics; innovation; insight; instrument; light weight; millisecond; miniaturize; multimodality; multisensory; nervous system disorder; neural; neurofeedback; neuroimaging; new technology; next generation; novel; novel strategies; portability; response; sensory stimulus; signal processing; social communication; tool; visual tracking; wearable device

Innovations in human neuroimaging tools have driven profound advances in our understanding of brain function under well-controlled and constrained conditions. While we are gaining greater understanding of how the brain functions in single-snapshot experiments under restricted lab settings, we do not know how it works in dynamic, complex and multisensory real-world environments. The goal of this project is to build a portable, miniaturized, lightweight, high-density wearable combined – functional Near Infrared-Spectroscopy (fNIRS) – Electro-Encepholography (EEG) - Eye-tracking system for enabling “Neuroscience of the Everyday World (NEW)” by permitting long duration continuous monitoring of normal / altered brain activity during movement, perception, and social interaction in real time and in the real world. In Aim 1, We will (A) develop a wearable and fully hybrid high-density EEG-fNIRS system that supports autonomous long-term recordings (>6 hours), (B) develop combined and miniaturized active EEG-Electrodes / fNIRS-Optodes; and (C) integrate the wearable system with Tobii Pro 2 eye-tracking/scene-camera glasses and state- of-the-art computer vision for adaptive acquisition and automated data annotation. In Aim 2, we will measure brain activity during walking, perceiving, and interacting, with experiments gradually increasing in complexity through three phases from lab to real world settings in young healthy adults and conduct a proof of principle in two sample clinical populations. In Aim 3, we will create an analysis workflow for data collected in Aim 2 that will accomplish the following: (1) removing nuisance signals from fNIRS/EEG signals, (2) analysis of multimodal fNIRS/EEG and behavioral data, (3) automatic annotation of and adaptation for real world measurements. This project brings together engineers, scientists and clinicians with the goal of building the next generation of imaging tools to capture brain function in real time. With our technological sophistication, interdisciplinary focus, and ready access to well-characterized clinical populations, we are uniquely positioned to successfully develop, apply, and disseminate our NEW technology, and lay down a foundation upon which groundbreaking advances in our understanding of the links between brain activity and behavior will build.

人类神经影像工具的创新在我们的理解中取得了深远的进步 在控制良好和受控条件下的大脑功能。虽然我们变得更大 了解在受限实验室下的单张照片实验中大脑的功能 设置，我们不知道它如何在动态，复杂和多感觉现实世界中起作用 环境。 该项目的目的是建造便携式，微型，轻巧，高密度可穿戴的目标 合并的 - 功能性近红外光谱（FNIRS） - 电脑线图（EEG） - 通过允许长时间来实现“日常世界神经科学（新）的神经科学”的眼睛追踪系统 持续时间对运动，感知期间的正常 /大脑活动的持续监测， 实时和现实世界中的社会互动。在AIM 1中，我们将（a）开发可穿戴 和完全混合高密度的EEG-FNIRS系统，该系统支持自动记录 （> 6小时），（b）开发了合并和微型活性的脑电图 / fnirs-optodes；和 （c）将可穿戴系统与Tobii Pro 2眼镜/场景相机玻璃和状态 - 用于自适应获取和自动数据注释的计算机愿景。在AIM 2中，我们 将在步行，感知和相互作用期间测量大脑活动，并逐渐与实验 从实验室到现实世界中的三个阶段，复杂性提高到年轻人健康 成人并在两个样本临床人群中进行原理证明。在AIM 3中，我们将创建 AIM 2中收集的数据的分析工作流将完成以下操作：（1）删除 来自FNIRS/EEG信号的滋扰信号，（2）多模式FNIRS/EEG和行为的分析 数据，（3）对现实世界测量的自动注释和适应性。 该项目汇集了工程师，科学家和临床医生，目的是建立下一个 生成成像工具，以实时捕获大脑功能。使用我们的技术 精致的，跨学科的重点，并可以随时进入特征良好的临床人群， 我们有独特的位置，可以成功开发，应用和传播我们的新技术， 并奠定基础，在我们对链接的理解中发展的基础 在大脑活动和行为之间将建立。