The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function

日常世界的神经科学——一种用于连续测量大脑功能的新型可穿戴系统

• 批准号: 10263915
• 负责人: David A Boas
• 金额: $ 120.85万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263915
• 关键词: Address; Adult; Algorithms; Area; Behavior; Behavioral; Blood Vessels; Brain; Brain imaging; Clinical; Cognition; Communication; Complement; Complex; Computer Vision Systems; Data; Development; Device or Instrument Development; Devices; Disease; Electrodes; Engineering; Environment; Failure; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Hour; Human; Hybrids; Imaging Device; Individual; Investigation; Laboratories; Link; Maps; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Motion; Movement; Near-Infrared Spectroscopy; Neurologic; Neurons; Neurosciences; Noise; Parkinson Disease; Pattern; Perception; Phase; Physiological; Population; Positioning Attribute; Rehabilitation therapy; Research; Research Personnel; Sampling; Scientist; Signal Transduction; Social Interaction; Speech; Stroke; Support System; System; Techniques; Technology; Text; Time; Translations; Walking; Work; density; design; experimental study; frontier; hemodynamics; innovation; insight; light weight; millisecond; miniaturize; multimodality; multisensory; nervous system disorder; neurofeedback; neuroimaging; new technology; next generation; novel; novel strategies; portability; relating to nervous system; response; sensory stimulus; signal processing; social communication; tool; visual tracking; wearable sensor technology

Innovations in human neuroimaging tools have driven profound advances in our understanding of brain function under well-controlled and constrained conditions. While we are gaining greater understanding of how the brain functions in single-snapshot experiments under restricted lab settings, we do not know how it works in dynamic, complex and multisensory real-world environments. The goal of this project is to build a portable, miniaturized, lightweight, high-density wearable combined – functional Near Infrared-Spectroscopy (fNIRS) – Electro-Encepholography (EEG) - Eye-tracking system for enabling “Neuroscience of the Everyday World (NEW)” by permitting long duration continuous monitoring of normal / altered brain activity during movement, perception, and social interaction in real time and in the real world. In Aim 1, We will (A) develop a wearable and fully hybrid high-density EEG-fNIRS system that supports autonomous long-term recordings (>6 hours), (B) develop combined and miniaturized active EEG-Electrodes / fNIRS-Optodes; and (C) integrate the wearable system with Tobii Pro 2 eye-tracking/scene-camera glasses and state- of-the-art computer vision for adaptive acquisition and automated data annotation. In Aim 2, we will measure brain activity during walking, perceiving, and interacting, with experiments gradually increasing in complexity through three phases from lab to real world settings in young healthy adults and conduct a proof of principle in two sample clinical populations. In Aim 3, we will create an analysis workflow for data collected in Aim 2 that will accomplish the following: (1) removing nuisance signals from fNIRS/EEG signals, (2) analysis of multimodal fNIRS/EEG and behavioral data, (3) automatic annotation of and adaptation for real world measurements. This project brings together engineers, scientists and clinicians with the goal of building the next generation of imaging tools to capture brain function in real time. With our technological sophistication, interdisciplinary focus, and ready access to well-characterized clinical populations, we are uniquely positioned to successfully develop, apply, and disseminate our NEW technology, and lay down a foundation upon which groundbreaking advances in our understanding of the links between brain activity and behavior will build.

人类神经影像工具的创新推动了我们理解的深刻进步 在良好控制和限制的条件下，我们的大脑功能得到了更大的提高。 了解受限实验室下的单次快照实验中大脑的功能 设置，我们不知道它如何在动态、复杂和多感官的现实世界中发挥作用 环境。 该项目的目标是打造一款便携式、小型化、轻量化、高密度的可穿戴设备 组合 – 功能性近红外光谱 (fNIRS) – 脑电图 (EEG) – 眼动追踪系统通过允许长时间观察来实现“日常世界的神经科学（新）” 持续监测运动、感知过程中正常/大脑活动的持续时间 在目标 1 中，我们将 (A) 开发一款可穿戴设备。 以及支持自主长期记录的完全混合高密度 EEG-fNIRS 系统 （> 6 小时），(B) 开发组合式微型有源 EEG 电极/fNIRS 光极；以及 (C) 将可穿戴系统与 Tobii Pro 2 眼球追踪/场景相机眼镜集成，并状态- 在目标 2 中，我们使用最先进的计算机视觉进行自适应采集和自动数据注释。 将通过实验逐步测量行走、感知和互动过程中的大脑活动 健康年轻人从实验室到现实世界环境的三个阶段的复杂性不断增加 在目标 3 中，我们将创建成人并在两个样本临床人群中进行原理证明。 针对目标 2 中收集的数据的分析工作流程，将完成以下任务：(1) 删除 来自 fNIRS/EEG 信号的干扰信号，(2) 多模态 fNIRS/EEG 和行为分析 数据，（3）自动注释和适应现实世界的测量。 该项目汇集了工程师、科学家和叛逆者，目标是建造下一个 利用我们的技术生成实时捕捉大脑功能的成像工具。 复杂性、跨学科重点以及随时接触特征良好的临床人群， 我们拥有独特的优势，能够成功开发、应用和传播我们的新技术， 并为我们对链接的理解取得突破性进展奠定基础 大脑活动和行为之间将会建立。