A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy

利用散斑对比光学光谱进行功能性脑成像的变革性方法

• 批准号: 10724661
• 负责人: David A Boas
• 金额: $ 41.73万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724661
• 关键词: Adoption; Adult; Brain; Brain Injuries; Brain imaging; Cerebrovascular Circulation; Cerebrum; Child; Device or Instrument Development; Diffuse; Disease; Environment; Fiber; Functional Magnetic Resonance Imaging; Future; Geometry; Health; Hemoglobin; Human; Image; Imaging Device; Imaging Techniques; Infant; Measurement; Measures; Metabolism; Methods; Modeling; Monitor; Motion; Near-Infrared Spectroscopy; Neurodegenerative Disorders; Noise; Optical Methods; Optics; Oxygen; Pathologic; Patient Monitoring; Pattern; Performance; Phase; Photons; Population; Resolution; Semiconductors; Signal Transduction; Source; Specificity; Spectrum Analysis; System; Time; Variant; Work; brain computer interface; cerebral hemodynamics; cost; cranium; data analysis pipeline; density; detector; functional near infrared spectroscopy; hemodynamics; imaging modality; improved; metabolic rate; metal oxide; neuroimaging; non-invasive monitor; novel strategies; portability; response; temporal measurement; tomography; tool; wearable device

Abstract Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring patients with brain injuries or neurodegenerative disease, studies of brain function in natural environments, and brain-computer interfaces. Among the various brain imaging techniques, functional near infrared spectroscopy (fNIRS) is an optical method that images the hemodynamic response to brain activation by measuring the oxy-(HbO) and deoxy-(HbR) hemoglobin concentration changes due to brain activation. It is especially useful for populations and for studies for which other imaging modalities are limited, e.g. functional magnetic resonance imaging (fMRI), including for children, infants, and studies that involve motion and interactions or require high temporal resolution. However, fNIRS brain sensitivity in adult humans is typically around 10%, and fNIRS alone does not provide quantitative information about all the hemodynamic parameters as it does not measure changes in cerebral blood flow (CBF). Here, we propose to develop a fiber-based speckle contrast optical spectroscopy (SCOS) system to measure CBF variations due to brain activation in humans. SCOS uses relatively low-cost complementary metal–oxide– semiconductor (CMOS) cameras as detectors. The performance of SCOS can surpass that of existing optical systems for human measurements of CBF in terms of contrast to noise ratio (CNR) by at least one order of magnitude with equal or less cost. The combined SCOS-fNIRS system developed in the UG3 phase will provide measurements of all the hemodynamic parameters associated with brain activation, achieve an up to 3x improvement in brain sensitivity compared with fNIRS alone, and permit estimation of evoked changes in CMRO2. The high-density SCOS-fNIRS system developed in the UH3 phase will provide images of all the hemodynamic parameters with high spatial and temporal resolution. This work will result in a new approach for functional brain imaging and demonstrative results that will motivate adoption by others and future advancements towards wearable devices at a reduced cost.

抽象的 在正常情况下对人脑功能的非侵入性监测的进步将导致 在我们对健康和疾病中大脑的理解中的突破，并导致设备的发展 可用于每天使用，并进行诸如监测脑损伤或神经退行性的患者之类的应用 疾病，自然环境中脑功能的研究以及脑机构界面。在各种 脑成像技术，功能性近红外光谱（FNIRS）是一种光学方法 血流动力学对脑激活的反应通过测量氧（HBO）和脱氧（HBR）血红蛋白 由于脑激活而导致的浓度变化。它对于人口和研究特别有用 其他成像方式有限，例如功能性磁共振成像（fMRI），包括儿童， 婴儿，以及涉及运动和相互作用或需要高临时分辨率的研究。但是，fnirs 成年人的脑敏感性通常约为10％，仅FNIRS不提供定量 有关所有血液动力学参数的信息，因为它没有测量脑血流（CBF）的变化。 在这里，我们建议开发基于纤维的斑点对比度光谱（SCOS）系统来测量 CBF由于人类的脑激活而引起的CBF变化。 SCO使用相对较低的成本完成金属 - 氧化物 - 半导体（CMOS）摄像机作为检测器。 SCO的性能可以超过现有光学的性能 与噪声比（CNR）形成鲜明对比（CNR）的人类测量系统至少 幅度相等或更低的成本。在UG3阶段开发的组合SCOS-FNIRS系统将提供 测量与大脑激活相关的所有血流动力学参数，达到3倍 与单独的FNIR相比，大脑敏感性的提高，并允许估计诱发变化 cmro2。在UH3阶段开发的高密度SCOS-FNIRS系统将提供所有的图像 具有高空间和临时分辨率的血液动力学参数。这项工作将导致一种新的方法 功能性的大脑成像和示范性结果，可以激发他人的采用和未来的进步 以降低的成本朝着可穿戴设备。

项目成果

Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

• DOI: 10.1038/s42003-023-05211-4
• 发表时间: 2023-08-14
• 期刊: COMMUNICATIONS BIOLOGY
• 影响因子: 5.9
• 作者: Kim, Byungchan;Zilpelwar, Sharvari;Sie, Edbert J.;Marsili, Francesco;Zimmermann, Bernhard;Boas, David A.;Cheng, Xiaojun
• 通讯作者: Cheng, Xiaojun