Administrative Core

行政核心

基本信息

批准号：
10495742
负责人：
CHARLES A O'BRIEN
金额：
$ 58.84万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-16 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10495742
关键词：
Advisory Committees Aging Agreement Applications Grants Area Arkansas Bioinformatics Biology Biomedical Research Bone Tissue Bone remodeling Cellular biology Centers of Research Excellence Collaborations Communication Data Set Dedications Department chair Development Development Plans Disease Doctor of Philosophy Endocrinology Evaluation Extramural Activities Faculty Fostering Foundations Functional disorder Funding Genetic Models Goals Growth Histology Human Infrastructure Institution Leadership Learning Medical Mentors Mentorship Molecular Musculoskeletal Musculoskeletal Diseases Musculoskeletal System Names Osteoblasts Osteocytes Peer Review Phase Physiology Pilot Projects Productivity Publications Publishing Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Science Scientist Services Structure Teacher Professional Development United States National Institutes of Health Universities Work bone imaging effective therapy experience member negative affect operation peer programs recruit skeletal success

项目摘要

PROJECT SUMMARY/ABSTRACT – CORE A Phase 1 of COBRE support established the Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that identification of molecular contributors to musculoskeletal dysfunction and disease will guide development of effective therapies. The Center achieved key milestones during Phase 1, including mentoring and support of junior investigators to the point of achieving independence, as defined by obtaining R01-level funding. These efforts, combined with recruitment of established investigators, have significantly expanded the number of successful musculoskeletal investigators in our Center. The three CMDR research cores established during Phase 1 also contributed to the success of our junior investigators and other center members and significantly strengthened the biomedical research infrastructure of our institution. An essential component of the effective operation of the CMDR was establishment of the Administrative Core (Core A), which manages the infrastructure, oversight, and day-to-day functioning of the Center. During Phase 2, the Administrative Core will continue to oversee all organizational and budgetary aspects of the CMDR, supported by internal and external advisory committees (Aim 1). In addition, the core will support CMDR growth via mentoring and a structured faculty development plan that will support Project Leaders to point of R01-level funding (Aim 2). The Administrative Core will also recruit and promote the development of new investigators via a Pilot Project Program, targeted recruitment of new investigators, and evaluation of Center progress by the advisory committees (Aim 3). These goals will be accomplished under the leadership of the Center Director and Associate Director who, with the support of experienced mentors and advisory committees, will enable Project Leaders focused on musculoskeletal research to compete effectively for R01-level funding. The Administrative Core will also oversee the operation of four Research Cores providing state-of-the-art services to create new genetic models (Core B), perform specialized skeletal histology and bank human bone tissue (Core C), provide bone imaging and quantification (Core D), and perform bioinformatic analyses of large molecular datasets (Core E). The overall success of this strategy will be gauged by achieving the following milestones within the five years of Phase 2 support: 1) three or more Project Leaders will obtain R01-level research grant support; 2) three or more new Project Leaders will be selected and join the Center; 3) Project Leaders and other Center members will publish between 25 and 50 peer-reviewed publications; and 4) graduated Project Leaders and other members of the Center will develop productive collaborations and submit a center-level grant application, such as a P01 or P30.

项目概要/摘要 – 核心 A COBRE 支持的第一阶段在美国成立了肌肉骨骼疾病研究中心 (CMDR) 阿肯色医科大学 (UAMS) 的科学主题是识别肌肉骨骼功能障碍和疾病的分子因素将指导有效疗法的开发。该中心在第一阶段实现了关键里程碑，包括对初级研究人员的指导和支持通过获得 R01 级资金来定义实现独立的点，并结合这些努力。招募已建立的研究人员，显着增加了成功的肌肉骨骼研究的数量我们中心的三个 CMDR 研究核心在第一阶段建立也做出了贡献。我们的初级研究人员和其他中心成员的成功，并显着加强了生物医学我们机构的研究基础设施是 CMDR 有效运作的重要组成部分。建立行政核心（核心 A），负责管理基础设施、监督和日常事务在第二阶段，行政核心将继续监督所有组织和工作。 CMDR 的预算方面，并得到内部和外部咨询委员会的支持（目标 1）。该核心将通过指导和教师结构化发展计划来支持 CMDR 的发展，该计划将支持 R01 级资金点的项目负责人（目标 2）行政核心还将招募和晋升通过试点项目计划培养新研究者，有针对性地招募新研究者，以及咨询委员会对中心进展情况进行评估（目标 3）。中心主任和副主任的领导，在经验丰富的导师和咨询委员会，将使专注于肌肉骨骼研究的项目负责人能够有效竞争行政核心还将监督四个研究核心的运作，提供 R01 级资助。最先进的服务，用于创建新的遗传模型（核心 B）、执行专门的骨骼组织学和数据库人体骨组织（核心 C），提供骨成像和定量（核心 D），并进行生物信息学大型分子数据集的分析（核心 E）将通过实现来衡量该策略的总体成功。第 2 阶段支持的五年内实现以下里程碑： 1) 三名或更多项目负责人将获得 R01级研究资助支持；2）选出3名或更多新项目负责人加入中心；项目负责人和其他中心成员将发表 25 至 50 篇经过同行评审的出版物；4) 毕业的项目负责人和中心的其他成员将开展富有成效的合作并提交中心级拨款申请，例如 P01 或 P30。