Center for Musculoskeletal Disease Research (CMDR)

肌肉骨骼疾病研究中心 (CMDR)

• 批准号: 10357772
• 负责人: CHARLES A O'BRIEN
• 金额: $ 227.44万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-16 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10357772
• 关键词: Address; Affect; Animals; Arkansas; Bioinformatics; Bone remodeling; Breast cancer metastasis; Cells; Centers of Research Excellence; Clinical; Clinical Investigator; Degenerative polyarthritis; Development; Development Plans; Disease; Doctor of Philosophy; Environment; Faculty; Foundations; Funding; Genetic Models; Genome; Goals; Grant; Health; Health Care Costs; Histology; Human; Image; Institutes; Institution; International; Lead; Malignant Neoplasms; Medical; Medicine; Mentors; Methods; Molecular Analysis; Multiple Myeloma; Mus; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Orthopedics; Osteomyelitis; Osteoporosis; Pathologic; Patients; Phenotype; Pilot Projects; Population; Process; Research; Research Infrastructure; Research Personnel; Research Project Grants; Sampling; Science; Scientist; Skeleton; Teacher Professional Development; Tissues; United States National Institutes of Health; Universities; Work; bone; disability; effective therapy; experience; genetic analysis; genetic manipulation; large datasets; malignant breast neoplasm; mouse genetics; multidisciplinary; negative affect; novel; novel therapeutics; operation; professor; programs; recruit; skeletal; success; transcriptome

PROJECT SUMMARY/ABSTRACT Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an ongoing need to better understand their causes and to support the development of more effective and well-tolerated therapies. To address this need, we propose to establish and develop a thematic and multidisciplinary Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that molecular and genetic analysis of musculoskeletal diseases, and conditions that involve the skeleton as part of their disease process, will lead to a better understanding of their causes and will support development of novel therapies. Our approach to studying these conditions will take advantage of state-of-the-art approaches to analyze the genome and transcriptome, the genetic manipulation of cells and animals, and skeletal phenotyping. A key to the success of this approach will be to increase the number of investigators whose research is aligned with the scientific theme of the Center via development of junior investigators and recruitment of new and established investigators. We will establish the CMDR on a strong foundation of musculoskeletal research and implement an Organization and Management Plan to create a self-sustaining Center of Biomedical Research Excellence (Aim 1). We will also provide multidisciplinary development and unique research opportunities to young investigators and support them to the point of independence (Aim 2). Lastly, we will create diverse teams of productive investigators by providing access to effective and useful research cores that produce significant and long-lasting benefits to the research infrastructure of UAMS and its affiliated institutions (Aim 3). The Overall Center Organization and Management Plan includes the Administrative Core, three research cores, and four research projects, led by promising junior investigators. The Administrative Core will oversee establishment and operation of the center, the three research cores, and a faculty development plan. The integrated and interactive faculty development plan will include a formal mentoring program that will guide four junior investigators to independence. The CMDR research cores include a Genetic Models Core that will use cutting-edge approaches to genetically manipulate cells and mice, a Bone Histology and Imaging Core that will analyze mouse and human hard tissues, and a Bioinformatics Core that will analyze the large datasets generated by the molecular analyses of cells from mouse and human samples. Successful implementation of this Organization and Management Plan will in the long-term lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for a variety of conditions that involve the musculoskeletal system.

项目概要/摘要 骨质疏松症、骨关节炎、骨骼发育异常等疾病 恶性肿瘤，例如多发性骨髓瘤和乳腺癌转移，都会对肌肉骨骼产生负面影响 系统。这些情况影响了相当大比例的美国人口的健康，并导致严重的 残疾和巨额医疗保健费用，并且持续需要更好地了解其原因和 支持开发更有效和耐受性良好的疗法。为了满足这一需求，我们建议 建立和发展主题性多学科肌肉骨骼疾病研究中心（CMDR） 阿肯色大学医学科学分校（UAMS）。 CMDR 的科学主题是分子 肌肉骨骼疾病以及涉及骨骼作为疾病一部分的病症的遗传分析 过程，将导致更好地了解其原因并支持新疗法的开发。我们的 研究这些条件的方法将利用最先进的方法来分析基因组 和转录组、细胞和动物的遗传操作以及骨骼表型分析。成功的关键 这种方法的目的是增加研究与科学相一致的研究人员的数量 该中心的主题是通过培养初级调查员和招募新的和已建立的调查员来实现。 我们将在肌肉骨骼研究的坚实基础上建立 CMDR，并实施一个组织 和管理计划，以创建一个自我维持的生物医学卓越研究中心（目标 1）。我们将 还为年轻研究者提供多学科发展和独特的研究机会和支持 让他们达到独立的程度（目标 2）。最后，我们将通过以下方式创建多元化的富有成效的调查人员团队 提供有效和有用的研究核心，为人们带来重大和持久的利益 UAMS 及其附属机构的研究基础设施（目标 3）。中心总体组织架构及 管理计划包括行政核心、三个研究核心和四个研究项目，由 有前途的初级研究者。行政核心将监督该中心的建立和运营， 三个研究核心和一个教师发展计划。综合性、互动性的师资发展 计划将包括一个正式的指导计划，指导四名初级调查员走向独立。 CMDR 研究核心包括遗传模型核心，它将使用尖端方法进行基因操纵 细胞和小鼠、可分析小鼠和人类硬组织的骨组织学和成像核心，以及 生物信息学核心将分析小鼠细胞分子分析生成的大型数据集 和人体样本。从长远来看，本组织和管理计划的成功实施将 建立一个自我维持的卓越生物医学研究中心，该中心将产生新颖且重要的成果 从而为涉及肌肉骨骼系统的各种疾病提供更有效的治疗方法。