Administrative Core

行政核心

• 批准号: 10357773
• 负责人: CHARLES A O'BRIEN
• 金额: $ 51.17万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-16 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10357773
• 关键词: Advisory Committees; Applications Grants; Area; Arkansas; Bioinformatics; Bone remodeling; Breast cancer metastasis; Centers of Research Excellence; Child; Data Set; Degenerative polyarthritis; Development; Development Plans; Disease; Evaluation; Extramural Activities; Faculty; Faculty Recruitment; Fostering; Funding; Genetic Models; Goals; Growth; Healthcare Systems; Infrastructure; Institution; International; Leadership; Measures; Medical; Mentors; Mentorship; Metastatic Neoplasm to the Bone; Molecular; Multiple Myeloma; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Neoplasm Metastasis; Osteomyelitis; Osteoporosis; Pathologic Processes; Peer Review; Pilot Projects; Process; Publications; Publishing; Research; Research Institute; Research Personnel; Research Project Grants; Science; Services; Skeletal Development; System; Teacher Professional Development; United States National Institutes of Health; Universities; Veterans; base; effective therapy; experience; member; multidisciplinary; novel therapeutics; operation; programs; ranpirnase; recruit; research and development; skeletal; skeletal tissue; success

PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish a thematic, multidisciplinary Center for Musculoskeletal Disease Research at the University of Arkansas for Medical Sciences (UAMS) via the COBRE mechanism. This will be a self-sustaining research center focused on identifying the molecular causes of diseases and conditions that negatively impact the musculoskeletal system or interact with this system as part of their disease process. Successfully establishing this COBRE will spur the development of new and effective therapies for a broad range of conditions, including osteoporosis, osteoarthritis, aberrant skeletal development, osteomyelitis, multiple myeloma, and cancer metastases to the bone. A key to the success of this Center will be the development of new independent investigators who are committed to team-based musculoskeletal research. To develop and operate this Center, the Administrative Core will establish the scientific and administrative infrastructure necessary to meet the needs of musculoskeletal researchers at UAMS and affiliated institutions and will oversee all organizational and budgetary aspects of Center development and function (Specific Aim 1). The Administrative Core will also implement a faculty development plan that will mentor four junior investigators to the point of independence, as measured by obtaining R01-level funding, and beyond (Specific Aim 2). The Administrative Core will support the growth of the Center by recruiting and promoting the development of new junior investigators to replace those that achieve independence via a pilot project program, the targeted recruitment of new investigators, and by effective Center evaluation (Specific Aim 3). These goals will be accomplished under the leadership of the Center Director who, with the support of experienced mentors and an Internal and External Advisory Committee, will guide four Project Leaders focused on musculoskeletal research to independence. The Administrative Core will also oversee the operation of three Research Cores providing state-of-the-art services to create new genetic models (Core B), perform specialized skeletal tissue analysis (Core C), and perform bioinformatic analyses of large molecular datasets (Core D). The overall success of this strategy will be gauged by achieving the following milestones within the first five years of Center funding: 1) three or more of the Project Leaders will successfully compete for NIH or federal R01-level research grant support to graduate to independent investigator status; 2) two to four new Project Leaders (and Mentors) will be selected and join the Center; 3) Project Leaders and other Center members will publish between 20 and 30 peer-reviewed publications; and 4) graduated Project Leaders and other members of the Center will be in the process of developing, or will have submitted, a center-level grant application, such as a P01 or P30.

项目概要/摘要 该应用程序的总体目标是建立一个主题性、多学科的肌肉骨骼疾病中心 阿肯色医学大学 (UAMS) 通过 COBRE 机制进行研究。这将是 一个自我维持的研究中心，专注于确定疾病和病症的分子原因 对肌肉骨骼系统产生负面影响或作为疾病过程的一部分与该系统相互作用。 成功建立该 COBRE 将促进针对广泛范围的新的有效疗法的开发 的疾病，包括骨质疏松症、骨关节炎、骨骼发育异常、骨髓炎、多种 骨髓瘤和癌症骨转移。该中心成功的关键是发展 新的独立研究人员致力于基于团队的肌肉骨骼研究。开发和 运营该中心，行政核心将建立科学和行政基础设施 满足 UAMS 和附属机构肌肉骨骼研究人员的需求是必要的，并将监督 中心发展和职能的所有组织和预算方面（具体目标 1）。这 行政核心还将实施一项教师发展计划，指导四名初级研究员 独立点，通过获得 R01 级资金及以上来衡量（具体目标 2）。这 行政核心将通过招募和促进新人才的发展来支持中心的发展 初级研究人员取代那些通过试点项目计划实现独立的研究人员，目标是 招募新的研究者，并通过有效的中心评估（具体目标 3）。这些目标将是 在中心主任的领导下，在经验丰富的导师和专家的支持下完成 内部和外部咨询委员会，将指导四名专注于肌肉骨骼研究的项目负责人 到独立。行政核心还将监督三个研究核心的运作，提供 创建新遗传模型（核心 B）、进行专门骨骼组织分析的最先进服务 （核心 C），并对大分子数据集进行生物信息学分析（核心 D）。此次活动的总体成功 将通过在中心资助的前五年内实现以下里程碑来衡量战略：1）三个 或更多项目负责人将成功竞争 NIH 或联邦 R01 级研究资助支持 毕业成为独立研究者； 2）将选出两到四名新的项目负责人（和导师） 并加入中心； 3) 项目负责人和其他中心成员将发表 20 至 30 篇经过同行评审的文章 出版物； 4) 毕业项目负责人和中心其他成员将在 正在制定或将要提交中心级拨款申请，例如 P01 或 P30。