Core A: Administrative Core

核心A：行政核心

• 批准号: 10654530
• 负责人: Margaret A. Pericak-Vance
• 金额: $ 74.92万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654530
• 关键词: Address; Advisory Committees; African; African American; Aging; Agreement; Alzheimer' s Disease; Amendment; Awareness; Budgets; Clinical; Collaborations; Communication; Communities; Complex; Data; Data Set; Dementia; Development; Elements; Ensure; Feedback; Funding; Genetic; Genetic Predisposition to Disease; Genetic Research; Genetic Risk; Genetic Variation; Genomics; Goals; Head; Hispanic; Individual; Infrastructure; Institution; Institutional Review Boards; International; Latinx population; Lead; Machine Learning; Minority; Minority Groups; Monitor; Nature; Neuropsychology; Not Hispanic or Latino; Occupational activity of managing finances; Participant; Persons; Population; Press Releases; Principal Investigator; Protocols documentation; Publications; Recommendation; Research; Research Personnel; Resources; Role; Sampling; Scientist; Site; Underserved Population; United States National Institutes of Health; Work; cohort; data sharing; diverse data; experience; functional genomics; genetic architecture; human subject protection; inter-institutional; meetings; neuropathology; post-doctoral training; recruit; response; symposium; video chat; web site

ABSTRACT The large number of sites (14) and the international nature of the READD-ADSP proposal make the logistical, regulatory and financial aspects particularly complex. Core A, the administrative core, provides the necessary oversight, coordination, and administrative infrastructure for this proposal. Core A will oversee the regulatory and financial aspects of our international collaboration and assure broad data sharing. The proper sharing of data and samples being collected necessitates the execution of a number of institutional agreements and assurance that the proper IRBs are in place. Core A will ensure that all documents have been signed and IRB approval has been obtained prior to the transfer of samples. An experienced Director of Finance will oversee all financial aspects, with close interaction and collaboration with the individual Core, Project and Site PIs at the different READD-ADSP institutions. Core A will coordinate and integrate all READD-ADSP components and activities. In a study this large, frequent communication is imperative. Semi-monthly video conferences of the MPIs and investigators will be organized and managed by Core A. Core A will coordinate and organize internal executive and external scientific advisory committee meetings. An internal executive committee of all the MPIs will meet every other month to review progress and address any outstanding issues. An external scientific advisory committee comprised of individuals with relevant expertise will meet four times a year (one in- person) to provide feedback. Core A will support these meetings and ensure that any recommendations are implemented. Lastly, Core A will facilitate the interaction with scientific communities relevant to READD- ADSP goals as well as the lay public. A resource is only valuable if people are aware of it. Core A will assist investigators with publicizing their work through national/international meetings, publications, and press releases and through the development of a website. The website will also contain information geared to the lay audience, including highlights of research funding and participation opportunities. Core A will also interface with NIA to keep them apprised of findings and to implement any changes that NIA requests.

抽象的 大量站点（14）和ReadD-ADSP提案的国际性质使后勤， 监管和财务方面特别复杂。核心A，行政核心提供了必要的 该提案的监督，协调和行政基础设施。核心A将监督监管 以及我们国际合作的财务方面，并确保广泛的数据共享。适当的分享 收集数据和样本需要执行许多机构协议，并且 保证适当的IRB已就位。核心A将确保已签署所有文件和IRB 样品转移之前已获得批准。经验丰富的财务总监将监督所有 财务方面，与个人核心，项目和现场PI进行紧密互动和合作 不同的readd-adsp机构。核心A将协调并集成所有readD-ADSP组件，并且 活动。在一项研究中，这种频繁的频繁交流是必须进行的。半月份的视频会议 MPI和调查人员将由核心A组织和管理A。核心A将协调并组织 内部高管和外部科学咨询委员会会议。一个内部执行委员会 所有MPI将每隔一个月开会一次，以审查进度并解决任何未来问题。外部 由具有相关专业知识的个人组成的科学咨询委员会将每年开会四次（一个 人）提供反馈。核心A将支持这些会议，并确保任何建议是 实施的。最后，核心A将促进与与Readd相关的科学社区的互动 ADSP目标以及外行公众。仅当人们意识到它时，资源才是有价值的。核心A将协助 调查人员通过国家/国际会议，出版物和新闻稿宣传其工作 并通过开发网站。该网站还将包含针对外行受众的信息， 包括研究资金和参与机会的亮点。核心A还将与NIA接口到 让他们了解调查结果并实施NIA要求的任何更改。