Core B: Outreach, Ascertainment, and Data Collection

核心 B：外展、确定和数据收集

• 批准号: 10333056
• 负责人: Margaret A. Pericak-Vance
• 金额: $ 387.91万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333056
• 关键词: Africa; African; African American population; Alzheimer' s Disease; American; Awareness; Biological; Biological Markers; Blood specimen; Clinical; Clinical Data; Collection; Country; DNA; Data; Data Collection; Dementia; Enrollment; Evaluation; Freezing; Future; Genetic Variation; Genetic study; Genotype; Goals; Hispanic; Individual; Infrastructure; Institutes; Latinx; Lead; Measures; Metadata; Methods; Modification; Motivation; Neurocognitive; Nigeria; Participant; Patients; Plasma; Population; Procedures; Process; RNA; Research Personnel; Resources; Sampling; Ships; Site; Tube; Universities; Work; adjudication; biobank; cohort; forest; genome sequencing; human genomics; member; neurocognitive test; outreach; phenotypic data; rare variant; recruit; whole genome

PROJECT SUMMARY/ABSTRACT: CORE B (Outreach, Ascertainment and Data Collection Core) The overall goal of Core B is to provide the infrastructure and support for the ascertainment and collection of phenotypic data and biological samples on 4000 African Americans (AA), 4000 Hispanic/Latinx Americans (HL) and 5000 Africans (AF) from the US and Africa. The phenotypic data gathered by Core B will sent to Core E and used for adjudication and harmonization by Core C, while the blood, plasma, and RNA samples collected by Core B will be sent to the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami (UM), used for DNA genotyping for Projects 1 and 2 and future WGS studies in FUS 2.0 and biomarkers and expression studies (Core D). The work of Core B will provide the necessary materials for both common and rare variant analysis and discovery in ancestral populations in the imputation studies in Projects 1 and 2. Specific Aim 1 will recruit and ascertain AA and HL participants in four US and nine AF sites. The AF sites are in eight different countries, all members of the African Dementia Consortium (AfDC). The University of Ibadan, Nigeria, will be the primary coordinating site for the other AfDC sites. We will ascertain ~13,000 individuals/participants (6,500 cases and 6,500 controls) consisting of AA (n=4,000), HL (n=4,000) and AF (n=5,000). Specific Aim 2. We will collect clinical, neurocognitive testing, blood samples and metadata on AA (n=4,000), HL (n=4,000) and AF (n=5,000) participants. Tubes for DNA, RNA and plasma will be collected. This study will provide a resource for future studies in AD in AA, AF and HL patients.

项目摘要/摘要：核心B（宣传，确定和数据收集核心） 核心B的总体目标是为确定和收集提供基础架构和支持 4000名非裔美国人（AA），4000名西班牙裔/拉丁裔美国人（HL）的表型数据和生物样品 来自美国和非洲的5000名非洲人（AF）。核心B收集的表型数据将发送到核心E 并用于核心C的裁决和协调，而收集的血液，血浆和RNA样品 核心B将发送给迈阿密大学的John P. Hussman人类基因组学研究所（HIHG） （UM），用于项目1和2的DNA基因分型以及FUS 2.0和生物标志物的未来WGS研究以及 表达研究（核心D）。核心B的工作将为常见和罕见的必要材料提供必要的材料 项目1和2的归纳研究中祖先人群中的变异分析和发现。 AIM 1将在美国和9个AF站点招募和确定AA和HL参与者。 AF站点八个 不同国家，非洲痴呆症联盟（AFDC）的所有成员。尼日利亚伊巴丹大学， 将是其他AFDC站点的主要协调站点。我们将确定约13,000个人/参与者 （6,500例和6,500个对照）由AA（n = 4,000），HL（n = 4,000）和AF（n = 5,000）组成。具体目标2。 我们将在AA（n = 4,000），HL（n = 4,000）和 AF（n = 5,000）参与者。将收集用于DNA，RNA和血浆的管。这项研究将提供资源 为了在AA，AF和HL患者中进行AD的未来研究。