Administrative Core

行政核心

• 批准号: 10628506
• 负责人: GABRIEL Alejandro DE ERAUSQUIN
• 金额: $ 314.42万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628506
• 关键词: Advisory Committees; Aging; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Assessment tool; Biocompatible Materials; Biological; Biological Markers; Clinical; Cognitive aging; Collaborations; Committee Members; Communication; Communities; DNA Repository; Data; Data Collection; Data Storage and Retrieval; Development; Elderly; Ensure; Environment; Ethics; Event; Exposure to; Faculty; Genes; Genetic Variation; Goals; Health; Impaired cognition; Individual; Institution; Institutional Review Boards; International; Leadership; Legal; Life Style; Mediation; Medical; Mentors; Methods; National Institute on Aging; Outcome; Persons; Population; Preparation; Progress Reports; Publications; Recommendation; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Risk; SARS-CoV-2 exposure; SARS-CoV-2 infection; Scientific Advances and Accomplishments; Scientific Inquiry; Services; Site; Specimen; Structure; Suggestion; Teacher Professional Development; Time Management; Underrepresented Populations; Visit; Work; Writing; career; cohort; comparison group; data collection site; data management; follow-up; genomic variation; lifestyle factors; meetings; neuroimaging; operation; outreach; programs; psychosocial; recruit; responsible research conduct; sample collection; statistics; symposium

AC Summary Abstract The Administrative Core (AC) will provide essential support and coordination to the other Cores and Projects of the Study on Interactions between SARS-CoV-2 infection and Ancestral genomic Variations in the Risk of Alzheimer's Disease (ISAVRAD). The AC will oversee the entire scientific direction of the U-19, manage its resources, and integrate the scientific research activities of the four Projects with the service activities of the six Cores. Operationally, the AC, in collaboration with the Clinical Core, will manage the transfer of samples from collection sites to the pertinent Cores, manage relationships between the sequencing centers and DNA repositories, oversee compliance and harmonization at international sites, and coordinate the activities of the Cores, including their data/materials exchanges with the scientific Projects. Five established committees will oversee the activities of the AC: Leadership, Long- Term Planning, Scientific Administrative, Fiscal & Management Oversight, and Publications. The aims of the AC are four-fold. First, we will manage the ISAVRAD and its internal relationships with the leaders of the Cores and Projects, including the leaders at the 5 data collection sites. Specifically, the AC will establish and revisit timely program priorities, optimize the sharing of resources among Cores and Projects, review data and specimen management needs, communicate scientific advances, promote scientific relationships and collaborations with other aging programs within the ISAVRAD network, and oversee ethical and legal issues (IRB etc.). Second, the CC will manage ISAVRAD relationships external to ISAVRAD, including communicating with the External Advisory Committee members, communicating, coordinating and collaborating with other aging studies to identify new and emerging areas of scientific inquiry relevant to the goals of ISAVRAD; oversee the preparation of annual progress reports for the National Institute on Aging; oversee the sharing of resources with investigators at outside institutions (e.g., data/material usage agreements); promote outreach to community residents at all recruitment sites to disseminate current topics on health, ADRD, and lifestyles, and disseminate scientific findings to the research community. Third, the AC will work with the Clinical, Neuroimaging, and Data Management and Statistics Cores to ensure harmonization of recruitment, data collection, data storage and management, and data/materials transfers throughout the ISAVRAD consortium. Fourth, the AC will oversee faculty development activities at each academic center affiliated with this U-19, including structured in-person mentoring and attendance at meetings/conferences.

AC摘要摘要 行政核心（AC）将为其他核心和项目提供基本的支持和协调 SARS-COV-2感染与祖先基因组变异之间的相互作用的研究 阿尔茨海默氏病（Isavrad）。 AC将监督U-19的整个科学方向，管理其 资源，并将四个项目的科学研究活动与六个项目的服务活动相结合 内核。在操作上，AC与临床核心合作将管理样本转移 收集到相关核心，管理测序中心与DNA之间的关系 存储库，监督国际遗址的合规性和协调，并协调 核心，包括与科学项目的数据/材料交换。五个成立委员会将 监督AC的活动：领导力，长期计划，科学行政，财政和 管理监督和出版物。 AC的目标是四倍。首先，我们将管理Isavrad 及其与核心和项目领导者的内部关系，包括5个数据的领导者 收集站点。具体而言，AC将建立和重新审视及时的计划优先级，优化共享 核心和项目之间的资源，审查数据和标本管理需求，交流科学 进步，促进科学关系以及与Isavrad中其他老龄化计划的合作 网络，监督道德和法律问题（IRB等）。其次，CC将管理Isavrad关系 伊萨夫拉德（Isavrad）外部，包括与外部咨询委员会成员沟通 与其他衰老研究进行沟通，协调和合作，以确定 与伊萨夫拉德的目标有关的科学探究；监督准备年度进度报告 国家老化研究所；监督与外部机构的调查员共享资源（例如 数据/材料使用协议）；在所有招聘地点向社区居民推广向社区宣讲 传播有关健康，ADRD和生活方式的当前主题，并向研究传播科学发现 社区。第三，AC将与临床，神经影像以及数据管理和统计数据一起工作 确保招聘，数据收集，数据存储和管理的核心以及 数据/材料在整个Isavrad联盟中转移。第四，AC将监督教师发展 与该U-19相关的每个学术中心的活动，包括结构化的面对面指导和 参加会议/会议。