Self-Regulation, Immunological Aging, and Health in Older Adults

老年人的自我调节、免疫衰老和健康

• 批准号: 9061536
• 负责人: SUZANNE C. SEGERSTROM
• 金额: $ 50.18万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9061536
• 关键词: Accounting; Age; Aging; Back; Behavioral; Biological Assay; Biological Markers; Biology; Blood; Cardiovascular Diseases; Cell Aging; Cognitive; Collaborations; Communicable Diseases; Data; Data Set; Elderly; Emotional; Funding; Health; Immune; Immune response; Immune system; Immunologic Markers; Immunology; Individual; Individual Differences; Inflammatory; Influenza vaccination; Informal Social Control; Interleukin-6; Link; Longitudinal Studies; Lymphocyte; Malignant Neoplasms; Measures; Mental Depression; Mental Health; Natural Killer Cells; Neuropsychology; Outcome; Pain; Personal Satisfaction; Physical activity; Psychological Factors; Research; Research Personnel; Resistance; Rest; Risk; Risk Factors; Role; Sampling; Serum; Short-Term Memory; Stress; T-Lymphocyte; Testing; Time; Vaccination; Visit; Work; age related; clinically relevant; cognitive function; cohort; cytokine; experience; feeding; healthy aging; heart rate variability; high risk; indexing; inflammatory marker; innovation; longitudinal analysis; longitudinal design; member; physical conditioning; physical inactivity; prospective; psychologic; psychosocial; receptor; satisfaction; senescence; shift work; social; waist circumference

DESCRIPTION (provided by applicant): Older adults are at high risk for a number of health problems, including cardiovascular disease, infectious disease, and cancer. Underlying at least part of this risk is immunological aging, but not all older adults experience immunological aging to the same degree, nor do they experience the same health risk and health problems. The purpose of this project is to measure individual differences and changes in self-regulation over time in older adults and to link self-regulation to subjective health, health risks, and clinically relevant markers of immunological aging, including inflammation and markers of lymphocyte terminal differentiation and replicative senescence. This is a competing renewal of this longitudinal study, which began in 2001 and received R01 funding in 2006, submitted by a research team with expertise in aging, self-regulation, neuropsychology, autonomic and inflammatory biology, immunology, and longitudinal design and analysis. The first period of the study focused on risk factors, especially stress and repetitive thought, and their effects on psychological well-being, subjective health, and immune response to vaccination. The renewal continues assessment of these risk factors to provide continuity in this longitudinal dataset and adds innovation in the assessment of factors that may promote healthy aging and mitigate against effects of risks. Specifically, the aims of the study are, first, to test the effects of a elf-regulatory constellation (comprising self-regulation, executive cognitive function, and heart rate variability [HRV]) on subjective psychological, social, and physical health and markers of immunological aging. Second, we will test the relationships between this constellation and risk factors such as age and stress. Third, we will test the ability of the constellation to moderate rik effects. A further aim is to support a "call for collaboration" in which we propose to work with other investigators whose hypotheses can be tested with study data from 2001 through the current renewal. At 6- month intervals, older adults (N = 150) will complete measures of the self-regulatory constellation: behavioral, emotional, social, and cognitive self-regulation; executive cognitive functions including inhibition, shifting, and working memory; and resting HRV. They will complete measures of risk including stress, pain, physical activity, BMI, and waist circumference. Finally, they will complete measures of psychosocial health including depression, perceived cognitive and physical health, and marital satisfaction. Blood draws will be synchronized with these visits, and assays performed on these samples will capture two aspects of immunological aging: increases in serum proinflammatory cytokines and their soluble receptors and increases in markers of terminal differentiation and senescence in T cells and NK cells. This renewal will be innovative in its comprehensive assessment of self-regulation as well as risk; the longitudinal design that allows for the study of change and lagged, mediational, and bidirectional effects; and the focus on the role of self-regulation in healthy aging.

描述（由申请人提供）：老年人面临许多健康问题的高风险，包括心血管疾病，传染病和癌症。至少部分这种风险的基本是免疫老化，但并非所有老年人都经历了相同程度的免疫老化，也没有遇到相同的健康风险和健康问题。该项目的目的是衡量老年人随着时间的流逝的个体差异和自我调节的变化，并将自我调节与主观健康，健康风险和临床上联系起来 免疫老化的相关标志物，包括炎症和淋巴细胞末端分化和复制衰老的标记。这是对这项纵向研究的竞争续约，该研究始于2001年，并于2006年获得了R01资金，该研究团队由一名研究团队提交，具有衰老，自我调节，神经心理学，自主和炎症生物学，免疫学，免疫学和纵向设计和分析和分析的专业知识。研究的第一阶段集中于危险因素，尤其是压力和重复思想，及其对心理健康，主观健康和对疫苗接种的免疫反应的影响。续签继续评估这些危险因素，以在此纵向数据集中提供连续性，并在评估可能促进健康衰老并减轻风险影响的因素的评估中增加了创新。具体而言，该研究的目的首先是测试ELF调节星座（包括自我调节，执行认知功能以及心率可变性[HRV]）对主观心理，社交和身体健康以及免疫老化的标志物的影响。其次，我们将测试该星座与年龄和压力等风险因素之间的关系。第三，我们将测试星座中等RIK效应的能力。另一个目的是支持“合作呼吁”，我们建议与其他调查人员合作，该研究人员可以通过2001年至当前续签进行研究数据测试假设。在6个月的间隔内，老年人（n = 150）将完成自我调节星座的衡量：行为，情感，社交和认知自我调节；执行认知功能，包括抑制，转移和工作记忆；和休息HRV。他们将完成风险衡量，包括压力，疼痛，身体活动，BMI和腰围。最后，他们将完成心理健康健康的措施，包括抑郁症，认知和身体健康以及婚姻满意度。抽血将与这些访问同步，在这些样品上进行的测定将捕获免疫衰老的两个方面：血清促炎细胞因子及其可溶性受体的增加，以及T细胞中终末分化和衰老的标记物的增加。这种更新将在对自我调节和风险的全面评估中具有创新性；纵向设计，可以研究变化和滞后，中介和双向效应；并关注自我调节在健康衰老中的作用。