Self-Regulation and Brain and Cognitive Health in Older Adults

老年人的自我调节与大脑和认知健康

• 批准号: 9383979
• 负责人: SUZANNE C. SEGERSTROM
• 金额: $ 66.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9383979
• 关键词: Adult; Affect; Age; Aging; Alzheimer' s disease risk; Anisotropy; Antibodies; Back; Behavior; Biological Assay; Blood; Brain; Cerebrovascular Circulation; Cognition; Cognitive; Communicable Diseases; Cytomegalovirus; Data; Dementia; Elderly; Eligibility Determination; Emotions; Episodic memory; Exercise; Failure; Funding; Goals; Health; Hippocampus (Brain); Image; Immunity; Immunologic Factors; Impaired cognition; Individual; Individual Differences; Infection; Inflammation; Informal Social Control; Knowledge; Latent Virus; Link; Longevity; Longitudinal Studies; Longitudinal cohort; Maintenance; Measures; Mediating; Mental Health; Motivation; Neurocognitive; Neuropsychology; Outcome; Parasites; Pathway interactions; Patient Self-Report; Physical activity; Prefrontal Cortex; Psychological Factors; Psychoneuroimmunology; Research; Rest; Risk; Risk Factors; Role; Sampling; Science; Serum; Short-Term Memory; Structure; Testing; Time; Toxoplasma gondii; Virus Latency; Visit; brain behavior; brain health; burden of illness; cardiovascular health; cognitive function; cohort; cytokine; dynamic system; executive function; experience; frontal lobe; heart rate variability; immune health; inflammatory marker; innovation; interest; latent infection; longitudinal analysis; longitudinal dataset; longitudinal design; multimodality; nervous system disorder; neuroimaging; physical conditioning; prospective; success; thought control; waist circumference

Summary The typical older adult experiences declines in brain structure and cognitive function, but these mean declines occur in the context of what can be very different individual trajectories. The purpose of this project is to measure individual differences and changes in self-regulation (control of thoughts, emotions, behaviors, and impulses) over time in older adults, and to link self-regulation to physical activity, inflammation, and trajectories of neurocognitive health. This is a competing renewal of this longitudinal study, which began in 2001 and received R01 funding in 2006, submitted by a research team with expertise in aging, self-regulation, exercise science, neuropsychology, neuroimaging, and longitudinal design and analysis. The previous renewal period focused on relationships among facets of self-regulation and their relationship to immunological and cardiovascular health. The renewal continues assessment of these measures to provide continuity in this longitudinal dataset and adds innovation in the inclusion of repeated neuroimaging and assessment of infectious disease burden. Specifically, the aims of the study are: (1) to test the effects of facets of self- regulation (conscientiousness, self-regulation, executive cognitive function, and heart rate variability) on measures of neurocognitive health associated with aging and risk for neurological disease; (2) to test the degree to which the relationship between self-regulation and neurocognitive health is mediated by physical activity and inflammation; (3) to test whether neurocognitive health associated with executive cognitive functions (e.g., dorsolateral frontal lobe volume) contributes to better self-regulation, higher physical activity, and lower inflammation; and (4) to test effects of infectious disease burden (latent viruses, Toxoplasma gondii) on self-regulation, inflammation, and neurocognitive health. At 6-month intervals, older adults (N = 175) will complete measures of self-reported self-regulation; executive cognitive functions including inhibition, shifting, and working memory; and resting HRV. Physical activity, BMI, and waist circumference will be measured at each visit. Blood draws will be synchronized with these visits, and assays performed on these samples will capture serum proinflammatory cytokines and antibodies against latent infections. The sample has follow-back data on many of these measures from 1-15 years, and an eligible subset (N = 90) will already have baseline neuroimaging. Neuroimaging will be repeated twice at 2-year intervals. This renewal will be innovative in its longitudinal assessment of a dynamic system that includes brain, behavior, and immunity; integration of neuroimaging measures with other domains of healthy and unhealthy aging; and multimodal assessment of neurocognitive health, including subjective cognitive health, cognitive function, volumetric imaging measures, connectivity, fractional anisotropy, and resting cerebral blood flow.

概括 典型的老年人经历的大脑结构和认知功能下降，但这些平均值下降 发生在可能非常不同的单个轨迹的背景下。这个项目的目的是 衡量个体差异和自我调节的变化（控制思想，情感，行为和 随着时间的流逝，在老年人中），将自我调节与体育锻炼，炎症和轨迹联系起来 神经认知健康。这是这项纵向研究的竞争续约，该研究始于2001年， 2006年获得了R01资金，由一个研究团队提交，具有老化，自我调节，锻炼方面的专业知识 科学，神经心理学，神经影像学以及纵向设计和分析。上一个续签期 专注于自我调节方面之间的关系及其与免疫学和关系的关系 心血管健康。续订继续评估这些措施，以提供连续性 纵向数据集并在包括重复的神经影像学和评估中增加了创新 传染病负担。具体而言，该研究的目的是：（1）测试自我的方面的影响 监管（尽责，自我调节，执行认知功能和心率变异性） 与衰老和神经系统疾病风险相关的神经认知健康的措施； （2）测试 自我调节与神经认知健康之间关系的程度是由身体介导的 活动和炎症； （3）测试神经认知健康是否与执行认知有关 功能（例如，背外侧额叶体积）有助于更好的自我调节，更高的体育锻炼， 降低炎症； （4）测试传染病负担的影响（潜在病毒，弓形虫弓形虫） 关于自我调节，炎症和神经认知健康。在6个月的间隔中，老年人（n = 175）将 完全衡量自我报告的自我调节；执行认知功能，包括抑制，转移， 和工作记忆；和休息HRV。体育锻炼，BMI和腰围将在 每次访问。抽血将与这些访问同步，在这些样品上进行的测定将 捕获血清促炎细胞因子和抗潜在感染的抗体。样品有跟随 从1 - 15年开始的许多这些措施的数据以及合格的子集（n = 90）已经具有基线 神经影像学。神经影像学将以2年间隔重复两次。这种更新将具有创新性 包括大脑，行为和免疫力在内的动态系统的纵向评估；整合 与健康和不健康衰老的其他领域的神经影像措施；和多模式评估 神经认知健康，包括主观认知健康，认知功能，体积成像指标， 连通性，分数各向异性和静止的脑血流。