Inflammatory Biomarkers in Pediatric Obesity and Diabetes: Research and Mentoring

儿童肥胖和糖尿病的炎症生物标志物：研究和指导

• 批准号: 8311089
• 负责人: PIETRO R GALASSETTI
• 金额: $ 14.79万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311089
• 关键词: Adolescent; American; Area; Award; Biochemical; Biological Markers; Blood; Blood specimen; Breath Tests; California; Carbohydrates; Cardiovascular system; Child; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Commit; Development; Diabetes Mellitus; Doctor of Philosophy; Early Diagnosis; Evolution; Exercise; Exhalation; Extramural Activities; Faculty; Fatty acid glycerol esters; Foundations; Free Radicals; Funding; Funding Agency; Gases; Gender; Glucose; Grant; Human; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Hypoglycemia; Individual; Inflammation; Inflammatory; Ingestion; Institutes; Insulin; Insulin-Dependent Diabetes Mellitus; International; Internships; Journals; Laboratories; Lipids; Measurement; Measures; Medical Students; Mentors; Mentorship; Metabolic syndrome; Metabolism; National Institute of Child Health and Human Development; Nature; Neonatology; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Oxidative Stress; Paper; Pathogenesis; Physical Fitness; Physiological; Placebos; Plasma; Population; Postdoctoral Fellow; Publishing; Publishing Peer Reviews; Regulation; Research; Research Activity; Research Personnel; Research Project Grants; Role; Sampling; Scholarship; Screening procedure; Services; Structure; Techniques; Testing; Time; Training Programs; Translational Research; United States National Institutes of Health; Universities; Wages; abstracting; base; biological adaptation to stress; career; diabetic; diabetic patient; graduate student; improved; inflammatory marker; middle school; neutrophil; novel; obesity in children; patient oriented; patient oriented research; pediatric pharmacology; professor; programs; public health relevance; research study; response; volatile organic compound

DESCRIPTION (provided by applicant): Pietro Galassetti, MD PhD, is an Associate Professor in the Departments of Pediatric and Pharmacology of the University of California, Irvine, where he also serves as Director of the Metabolism and Bionutrition Core at the Institute for Clinical and Translational Science (ICTS, formerly GCRC). He has been involved in Patient Oriented Research for the last 20 years, and currently is PI on 2 extramural grants (including an NIH RO1), focused on projects with the common theme of defining the biochemical mechanisms underlying the early development of complications in dysmetabolic states, such as obesity, metabolic syndrome, type 1 (T1DM) and type 2 diabetes (T2DM). His current main specific research topics are: a) The development of a non-invasive technique for the measurement of plasma glucose, insulin and lipids through integrated analysis of exhaled volatile organic compounds; b) The definition of inflammatory and oxidative stress mechanisms during exercise in children with obesity and metabolic syndrome. These projects are fully patient-oriented and translational in nature. Maintaining and improving adequate research funding for the evolution of these projects will be challenging in coming years. With this application, support for 50% of Dr. Galassetti's professional effort is requested, of which half, or 25% of his total time, will be devoted to completing novel, exploratory experiments in the 2 research areas outlined above, aimed at facilitating the acquisition of additional research funding. Dr. Galassetti has published extensively on translational research topics in high-impact journals (35 published peer reviewed papers in the last 5 years only, out of a total of 78); he acts as reviewer to over twenty scientific journals, several grant funding agencies (NIH, JDRF, and other national and international foundations). A large share of Dr. Galassetti's time is taken up by mentoring activities, These include: a) direct mentoring of UCI residents, fellows, medical and graduate students who participate in Dr. Galassetti's research projects; b) mentoring of junior faculty who are trying to develop independent research lines; c) mentoring of junior investigators involved in clinical-translational projects with other PIs, requesting Dr. Galassetti's expertise; d) mentoring through structured UCI mechanisms, such as the Bio 199 Clinical Research Course, Internships for the UCI Clinical Trial Courses, the UCI Mentored Medical Student Clinical Research Program, the Neonatology Fellows Scholarship Oversight Committee, etc. Many of his trainees co-authored abstracts and papers based on recent study results, and several have won regional and national research awards while under his mentorship. The remaining 25% of the requested salary support will therefore be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research. This award will allow to considerably reduce his current onerous amount of administrative and service duties, and proportionally increase protected time dedicated to mentoring and research activities in translational science. PUBLIC HEALTH RELEVANCE: Pietro Galassetti, MD PhD, is a researcher at the University of California, Irvine, and has been involved in Patient Oriented Research for 20 years. He has 2 funded research projects, with the common theme to define the early development of complications of obesity and diabetes: a) The development of a novel technique to measure glucose, insulin and fat from human breath (i.e. not requiring a blood sample); b) The study of the damage from inflammation and free radicals during exercise in obese children. Both projects are clear examples of patient-oriented research. With this application, 50% salary support is requested for Dr. Galassetti's; of which 25% will be devoted to novel, exploratory experiments that will expand current projects and facilitate acquisition of additional research funding. Dr. Galassetti has published extensively in high-level scientific journals (35 papers in the last 5 years, out of a total of 78). A large share of Dr. Galassetti's time is taken up by mentoring activities, for UCI clinical residents and fellows, post-doctoral fellows, medical and graduate students. The remaining 25% of the requested salary support will be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research, and this award will result in reduced administrative duties and more protected time, increasing his current levels of mentoring and research activities.

描述（由申请人提供）：MD PhD Pietro Galassetti是加利福尼亚大学尔湾分校的儿科和药理学系的副教授，在那里他还担任代谢和Bionutrition Core的主任，担任临床和翻译科学研究所（ICTS，前GCRC）。 He has been involved in Patient Oriented Research for the last 20 years, and currently is PI on 2 extramural grants (including an NIH RO1), focused on projects with the common theme of defining the biochemical mechanisms underlying the early development of complications in dysmetabolic states, such as obesity, metabolic syndrome, type 1 (T1DM) and type 2 diabetes (T2DM).他目前的主要研究主题是：a）通过对呼出的挥发性有机化合物的综合分析来测量血浆葡萄糖，胰岛素和脂质的非侵入性技术； b）肥胖和代谢综合征儿童运动过程中炎症和氧化应激机制的定义。这些项目本质上完全注重患者和翻译。在未来几年中，维持和改善这些项目发展的适当研究资金将具有挑战性。通过此应用，请求支持加拉塞蒂博士的专业努力的50％，其中一半或总时间的25％将专门用于完成上面概述的两个研究领域的小说，探索性实验，旨在促进批次批次批次批准其他研究资金。 Galassetti博士广泛发表了有关高影响力期刊的翻译研究主题（在过去的5年中，有35篇发表的同行评审论文，总共78个）；他担任二十多个科学期刊，几家赠款机构（NIH，JDRF以及其他国家和国际基金会）的审稿人。 Galassetti博士的很大一部分是通过指导活动所占据的，其中包括：）直接指导UCI居民，研究员，医学和研究生，他们参加了Galassetti博士的研究项目； b）试图发展独立研究界的初级教师的指导； c）指导与其他PI一起参与临床翻译项目的初级调查人员，要求Galassetti博士的专业知识； d）通过结构化的UCI机制进行指导，例如Bio 199临床研究课程，UCI临床试验课程的实习，UCI指导了医学学生临床研究计划，新生儿学奖学金奖学金奖学金委员会等。他的许多受训者共同撰写了基于最新研究成果的摘要和纸张，并获得了几个研究成果，并获得了国家研究员的奖学金，并在他的国家研究员中获得了奖励。因此，其余25％的薪水支持将致力于继续和扩展这些指导活动。总而言之，Galassetti博士完全致力于以患者为导向的研究。该奖项将大大减少他目前的繁重行政和服务职责，并按比例增加致力于转化科学指导和研究活动的受保护时间。 公共卫生相关性：医学博士Pietro Galassetti是加利福尼亚大学尔湾分校的研究员，并且已经参与了以患者为导向的研究。他有2个资助的研究项目，其共同主题是定义肥胖和糖尿病并发症的早期发展：a）一种新型技术来测量人类呼吸中的葡萄糖，胰岛素和脂肪（即不需要血液样本）； b）研究肥胖儿童期间炎症和自由基的损害。这两个项目都是面向患者的研究的明确例子。通过此申请，Galassetti博士要求提供50％的薪水支持；其中25％将专门用于新颖的探索性实验，这些实验将扩大当前的项目并促进获得额外的研究资金。 Galassetti博士已广泛发表在高级科学期刊上（过去5年中的35篇论文，共有78篇）。 Galassetti博士的很大一部分时间是通过指导活动，UCI临床居民和研究员，博士后研究员，医学和研究生的指导活动所占据的。其余25％的要求的工资支持将致力于这些指导活动的继续和扩展。总而言之，Galassetti博士完全致力于以患者为导向的研究，这一奖项将导致行政职责减少和更受保护的时间，从而提高了他目前的指导和研究活动水平。