HYPOGLYCEMIA AND EXERCISE IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

患有 1 型糖尿病的儿童和青少年的低血糖与运动

• 批准号: 8166897
• 负责人: PIETRO R GALASSETTI
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166897
• 关键词: Adolescent; Attenuated; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Event; Exercise; Funding; Grant; Hypoglycemia; Incidence; Institution; Insulin-Dependent Diabetes Mellitus; Life; Patients; Research; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; blood pressure regulation; cardiovascular disorder prevention; cognitive function; fetal; glycemic control; improved; insulin sensitivity; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim of this project is to determine whether in children/adolescents with Type 1 Diabetes, the adaptive glucoregulatory response to exercise is attenuated, contributing to the high incidence of hypoglycemia occurring in this group of patients. In the management of patients with Type 1 diabetes mellitus (T1DM), hypoglycemia is a major clinical problem. Hypoglycemia may disrupt daily activities, cause life-threatening events, induce fetal damage, alter cognitive function in children, and exert long-term negative effects on intellectual function. Hypoglycemia often occurs in association with physical exercise, often forcing patients to renounce several beneficial effects of exercise, including improved insulin sensitivity and glycemic control, and improved control of blood pressure and prevention of cardiovascular disease, for which these patients are at elevated risk.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的具体目的是确定在患有1型糖尿病的儿童/青少年中是否会减弱对运动的适应性葡萄糖调节反应，从而导致这组患者发生低血糖的高发病率。 在1型糖尿病（T1DM）患者的治疗中，低血糖是一个主要的临床问题。 低血糖可能会破坏日常活动，引起威胁生命的事件，诱发胎儿损害，改变儿童的认知功能，并对智力功能产生长期负面影响。 低血糖通常与体育锻炼有关，通常迫使患者放弃运动的几种有益作用，包括提高胰岛素敏感性和血糖控制，并改善对血压和预防心血管疾病的控制，这些患者的风险升高。