EXERCISE AND OXIDATIVE STRESS MECHANISMS

运动和氧化应激机制

• 批准号: 7951051
• 负责人: PIETRO R GALASSETTI
• 金额: $ 6.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951051
• 关键词: Adolescent; Adult; Antioxidants; Cardiovascular system; Child; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Defense Mechanisms; Dyslipidemias; Elements; Exercise; Frequencies; Funding; Generations; Grant; Human; Hyperglycemia; Hypertension; Indium; Institution; Metabolic Diseases; Metabolic syndrome; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Oxidative Stress; Pathogenesis; Pathology; Physical activity; Production; Reactive Oxygen Species; Regulation; Research; Research Personnel; Research Support; Resources; Role; Source; United States National Institutes of Health; cost; diet and exercise; nutrition; sound; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a recent conference sponsored by the NICHD and NIDDK, an alarm was sounded by a group of nationally known investigators that elements of the emerging metabolic syndrome [a constellation of pathologies consisting of obesity, dyslipidemia, hypertension and hyperglycemia] (1) are appearing in increasing frequency in children and adolescents (2). If unchecked, we will witness an unprecedented level of cardiovascular and metabolic disease as this generation becomes adults, and the morbidity and cost will be staggering. While the pathogenic mechanisms of the metabolic syndrome and its elements in children are not fully understood, recent research supports a role for an imbalance between production of reactive oxygen species (ROS) and antioxidant defenses, inducing oxidative stress (3-5). This is compelling because physical activity and nutrition are among the most important naturally occurring modifiers of ROS production and antioxidant defense mechanisms in humans (6-12). In children, key mechanisms governing the interactions among exercise, diet, and the regulation of oxidative stress in the pathogenesis of the metabolic syndrome have yet to be investigated.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在NICHD和NIDDK的最新会议上，一群全国知名的调查员发出了警报，称新兴代谢综合征的元素[肥胖，血脂血症，高血压和高血糖症组成的病理学星座出现在儿童和青少年的频率越来越多。 如果不受组织的检查，随着这一代人成为成年人，我们将目睹空前的心血管和代谢疾病水平，发病率和成本将令人震惊。 虽然尚未完全了解代谢综合征的致病机制及其在儿童中的元素，但最近的研究支持了活性氧（ROS）（ROS）和抗氧化剂防御剂之间产生不平衡的作用，从而诱导氧化应激（3-5）。 这是令人信服的，因为体育活动和营养是人类中最重要的自然发生的ROS产生和抗氧化剂防御机制之一（6-12）。 在儿童中，尚待研究代谢综合征发病机理中锻炼，饮食和氧化应激之间相互作用的关键机制。