BIOMARKERS OF GLUCOSE METABOLISM IN EXHALED BREATH

呼出气中葡萄糖代谢的生物标志物

• 批准号: 8166907
• 负责人: PIETRO R GALASSETTI
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166907
• 关键词: Award; Biological Markers; Blood Glucose; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Detection; Exhalation; Funding; Gases; Grant; Human; Institution; Measurement; Metabolic; Metabolism; Methodology; Monitor; Nobel Prize; Patients; Problem Solving; Research; Research Personnel; Resources; Source; Technology; United States National Institutes of Health; glucose metabolism; innovation; interest; non-invasive monitor; volatile organic compound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose an innovative approach to the field of non-invasive monitoring of blood glucose and related variables, the detection and quantification of trace amounts of Volatile Organic Compounds (VOCs) in exhaled human breath as biomarkers endogenous metabolism. Exhaled gases represent an ideal set of potential biomarkers, as they can be collected easily and non-invasively from virtually any patient. While the potential of VOCs has been recognized for decades and several attempts have been made to utilize them for metabolic monitoring, intrinsic difficulties in measurement and analysis have resulted in inconsistent results, severely limiting their practical applicability. Recent advances in analytical technology, however, may have reduced, if not solved, these problems, and resulted in renewed interest in this methodology, with an exponentially rising number of studies focusing on its applications. Among the greatest contributors to these advances are Drs. Sherwood Rowland and Donald Blake, world renowned atmospheric chemists and co-investigators in this application (for his discoveries in atmospheric gas composition, Dr. Rowland was awarded the 1995 Nobel Prize for Chemistry).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们提出了一种创新的方法，用于对血糖和相关变量的非侵入性监测，在呼出的人类呼吸中的循环量的挥发性有机化合物（VOC）作为生物标志物内源代谢的检测和定量。 呼气的气体代表了一组理想的潜在生物标志物，因为它们几乎可以从任何患者中轻松而无创地收集。 尽管VOC的潜力已被认可了数十年，并且已经进行了几次尝试将其用于代谢监测，但测量和分析的内在困难导致了不一致的结果，严重限制了它们的实际适用性。 然而，分析技术的最新进展可能会减少（即使没有解决）这些问题，并引起了对这种方法的重新兴趣，并且始终增加了针对其应用的研究。 这些进步的最大贡献者之一是Drs。 Sherwood Rowland和Donald Blake是该应用程序中世界著名的大气化学家和共同投资者（对于他在大气气体组成方面的发现，Rowland博士被授予1995年诺贝尔化学奖）。