SPARKLED: Social Programming Affects Risk in Kids of Latent Endothelial Disease
SPARKLED:社交编程会影响儿童潜在内皮疾病的风险
基本信息
- 批准号:10663819
- 负责人:
- 金额:$ 4.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-19 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Project Summary/Abstract
Cardiovascular complications are the leading cause of maternal mortality in the United States. The burden of
poor cardiovascular health falls disproportionately on impoverished and non-White communities where
structural racism limits access to quality care, thus impacting health outcomes. Social health programming
(SHP) is an intervention designed to mitigate adverse social experiences by empowering communities to
address modifiable risk factors for poor health. SHP for adolescents has been shown to improve health
outcomes and mitigate certain cardiometabolic risk factors, including poor nutrition and exposure to
psychosocial stressors. However, the long-term impacts of adolescent participation in SHP on cardiovascular
health and its impact on future pregnancies are not known. In this proposal, we will partner with a nationally
recognized after-school program offering SHP (Girls Inc., Omaha) to address this gap in the scientific literature.
We hypothesize that SHP with nutritional and emotional resiliency components will positively impact
adolescent modifiers of adult cardiovascular disease. To test this hypothesis, we will compare nutritional
antioxidant status (Specific Aim 1), hair/saliva cortisol levels (Specific Aim 2), and vascular elasticity (Specific
Aim 3) in current/former SHP participants versus age-matched controls. Dietary patterns and emotional
resiliency will be measured using validated questionnaires. Nutritional antioxidant status (a marker of
cardiovascular inflammation) will be measured using liquid chromatography with tandem mass spectrometry
(LC-MS/MS). Cortisol levels (a marker of psychological stress) will be measured in hair and saliva using
enzyme-linked immunoassay (ELISA). Vascular reactivity (a marker of latent endothelial disease) with be
measured using a VENDYS® test. Our research will inform the design of SHP for adolescents and contribute to
the elimination of sociodemographic disparities in maternal mortality via the mitigation of cardiovascular
complications. In addition to this dissertation research, I have developed a training plan to enrich my scientific
and professional development as a physician-scientist trainee at the University of Nebraska Medical Center
(UNMC). I will achieve the following training goals: build foundational knowledge and technical skills in
pediatric health disparities, develop capacity to independently design and implement research projects, master
written and verbal scientific communication skills, and integrate my clinical and scientific skillsets. Throughout
my graduate training, UNMC will provide essential coursework, grant writing workshops, seminars, and other
skill-building opportunities that enhance my technical expertise and professional development. Altogether, the
research and training opportunities outlined in this proposal will empower me to become an adept physician-
scientist and an innovative leader in the field of pediatric health disparities.
项目摘要/摘要
心血管并发症是美国孕产妇死亡率的主要原因。燃烧的
贫穷的心血管健康不成比例地落在贫困和非白人社区上
结构性种族主义限制了获得优质护理的机会,从而影响了健康结果。社会健康计划
(SHP)是一种干预措施,旨在通过赋予社区权力来减轻广告社会体验
解决不良健康的可修改风险因素。已证明为青少年的SHP改善健康
结果并减轻某些心脏代谢危险因素,包括营养不良和暴露
社会心理压力源。但是,青少年参与SHP对心血管的长期影响
健康及其对未来怀孕的影响尚不清楚。在此提案中,我们将与全国合作
认可提供SHP(奥马哈女子公司)的课后计划,以解决科学文献中的这一差距。
我们假设具有营养和情感弹性成分的SHP将对
成人心血管疾病的青少年修饰符。为了检验这一假设,我们将比较营养
抗氧化剂状态(特定目标1),头发/唾液皮质醇水平(特定AIM 2)和血管弹性(特定
AIM 3)在当前/以前的SHP参与者与年龄匹配的对照中。饮食模式和情感
弹性将使用经过验证的问卷来衡量。营养抗氧化剂状态(标记
心血管炎症)将使用液相色谱和串联质谱法测量
(LC-MS/MS)。皮质醇水平(心理压力的标记)将在头发和唾液中使用
酶联免疫测定(ELISA)。 Be的血管反应性(潜在内皮疾病的标志)
使用Vendys®测试测量。我们的研究将为青少年的SHP设计提供信息,并为
通过缓解心血管消除孕产妇死亡的社会人口统计学差异
并发症。除了这项论文研究外,我还制定了一项培训计划来丰富我的科学
内布拉斯加州大学医学中心的身体科学家学员的专业发展
(UNMC)。我将实现以下培训目标:建立基础知识和技术技能
小儿健康分布,独立设计和实施研究项目的发展能力,硕士
书面和口头科学沟通技巧,并整合了我的临床和科学技能。自始至终
我的研究生培训,UNMC将提供必不
技能建设机会可以增强我的技术专业知识和专业发展。总共
该提案中概述的研究和培训机会将使我成为一名熟练的医生 -
科学家和儿科健康分配领域的创新领导者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
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