Patient Oriented Research In Clinical Nutrition

以患者为中心的临床营养研究

• 批准号: 8384510
• 负责人: Thomas R Ziegler
• 金额: $ 17.75万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-16 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8384510
• 关键词: Area; Bioinformatics; Biological Markers; Clinical; Clinical Investigator; Clinical Nutrition; Clinical Research; Clinical Sciences; Commit; Critical Care; Critical Illness; Cystic Fibrosis; Development; Diet; Dietary Intervention; Discipline; Discipline of Nursing; Doctor of Philosophy; Dose; Faculty; Female; Foundations; Funding; Funding Applicant; Generations; Glutamine; Goals; Grant; Health Sciences; Industry; Institutes; International; Journals; Junior Physician; Leadership; Link; Medical; Medical Students; Medicine; Mentors; Metabolic; Metabolism; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority Groups; Molecular; Nutrition Assessment; Nutritional; Nutritional Study; Operative Surgical Procedures; Outcome; Oxidation-Reduction; Patients; Pediatrics; Physicians; Plasma; Postdoctoral Fellow; Productivity; Publications; Pulmonary Tuberculosis; Recording of previous events; Research; Research Activity; Research Design; Research Institute; Research Personnel; Research Training; Resources; Role; Sampling; Science; Services; Short Bowel Syndrome; Sickle Cell Anemia; Societies; Source; Specialist; Study Section; Therapeutic; Time; Training; Training and Education; Translational Research; United States National Institutes of Health; Vitamin D; Wages; Western Asia Georgia; career development; editorial; ethnic minority population; global health; graduate student; innovation; investigator training; member; metabolomics; multidisciplinary; novel; nutrition; patient oriented; patient oriented research; patient population; post-doctoral training; pre-doctoral; professor; programs; skills; tool; undergraduate student

DESCRIPTION (provided by applicant): This competing renewal application for the Midcareer Investigator Award in Patient Oriented Research (K24) "Patient-Oriented Research in Clinical Nutrition" seeks support for an accomplished physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. remains highly committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring undergraduates, graduate and medical students, postdoctoral fellows, clinical residents, and junior faculty in clinical nutrition research to continue to develop a needed new cadre of well-trained investigators in Clinical Nutrition. Renewal of this proposal will provide protected time t enable the P.I. to continue to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources in state-of-the-art metabolomics methods that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He maintains a strong and growing publication record, renewed independent funding for POR from NIH and other sources, a continued history of leadership roles in national nutrition- related societies, and increasing service on the editorial boards of front-line nutrition-oriented research journals. At Emory, the P.I. serves in the leadership of the NIH-funded CTSA grant, the Atlanta Clinical and Translational Science Institute (ACTSI), including as Co-Program Director of the ACTSI Research Education, Training and Career Development (RETCD) program, Co-Program Director of the ACTSI/RETCD KL2 postdoctoral training grant, and Program Director of the ACTSI/RETCD TL1 predoctoral training grant (TL1 RR025010). He serves in leadership roles with the Center for Clinical and Molecular Nutrition, several T32 training grants and the Emory graduate program in Nutrition and Health Science - all of which provide opportunities for continued mentoring in POR. Since the initial funding of this K24 grant (07/01/07), the P.I. has mentored the clinical/translational research activities of 32 trainees, from the level of undergraduate student to junior faculty, including a current cadre of 3 physician junior faculty members from the Emory Departments of Medicine and Pediatrics, respectively; 2 Ph.D. junior faculty investigators; 4 international physician investigators from the former Soviet Republic of Georgia; 3 physician postdoctoral fellows; 4 Ph.D.-trained postdoctoral fellows; a Pharm.D. specialist in clinical nutrition support; 3 Emory Ph.D. graduate students (2 in Nutrition and Health Sciences and 1 in Nursing) and an Emory undergraduate student. The candidate's POR program provides a rich training substrate for current and potential mentees and includes ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis. PUBLIC HEALTH RELEVANCE: There is a national need to train new investigators, including physicians, in nutrition-oriented clinical research. The candidate for this K24 grant renewal has a well-established track record of research publications, NIH and other funding, and leadership roles and mentoring in patient-oriented clinical nutrition research. Renewal of his K24 grant will provide the protected time and resources to allow the applicant to continue to grow his cadre of multidisciplinary mentees in this area, and to further develop the novel research area of nutritional metabolomics as a tool for biomarker discovery, nutritional assessment and outcome prediction.

描述（由申请人提供）：这项竞争性续签申请在以患者为导向的研究中的中级研究员奖（K24）“以患者为导向的临床营养研究”寻求支持为有成就的医师营养专家的支持，并在临床和翻译营养科学领域建立了研究者。 P.I.仍然致力于进行以患者为导向的研究（POR），专注于营养，并指导本科生，研究生和医学生，博士后研究员，临床居民以及临床营养研究的初级教师，以继续开发一项所需的新的在临床营养中经过良好学位的研究人员。该提案的续订将提供受保护的时间t使P.I.继续推进他的研究和指导营养方面的研究，并提供最先进的代谢组学方法的额外培训和资源，从而增强了他指导医生和其他临床研究人员的能力 在与营养有关的研究中。申请人在营养和医学方面具有独特的培训背景，并为他的研究人员发起的POR和转化研究提供了联邦，基金会和行业资金的良好记录。他保持了强劲而不断增长的出版记录，从NIH和其他来源为POR恢复了独立资金，在国家营养相关社会中的领导角色持续历史，以及在面向前线营养的研究期刊的编辑委员会上的服务不断增加。在埃默里（Emory）在NIH资助的CTSA Grant，Atlanta临床和翻译科学研究所（ACTSI）的领导下，包括作为ACTSI研究教育，培训和职业发展（RETCD）计划的共同编程总监，ACTSI/RETCD KL2 KL2 KL2 KL2 KL2 KL2 KL2 COSTORAL培训培训总监ACTSI/RETCSI/RETCD TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 RR025010）。他曾在临床和分子营养中心，几项T32培训补助金以及埃默里营养与健康科学研究生计划中担任领导职务 - 所有这些都为继续在POR提供指导提供了机会。自此K24 Grant（07/01/07）的最初资金以来，P.I。从本科生到初级教师，包括32名学员的临床/转化研究活动，包括分别来自埃默里医学和儿科部门的3名医师初级教师的目前干部； 2博士初级教师调查员； 4来自佐治亚州前苏联共和国的国际医师调查员； 3个医师博士后研究员； 4博士学位训练的博士后研究员； Pharm.D。临床营养支持专家； 3 Emory Ph.D.研究生（营养和健康科学领域2名，护理中有1个）和一名埃默里大学生。候选人的POR计划为当前和潜在的受训者提供了丰富的训练底物，包括对谷氨酰胺在分解代谢状态的疗效和代谢影响的研究，包括重症监护，短肠综合征，囊性纤维化。镰状细胞贫血，与饮食相关的氧化还原控制和代谢组学分析。 公共卫生相关性：在以营养为导向的临床研究中培训包括医生在内的新调查人员的国家需求。此K24授予申请的候选人有一个 良好的研究出版物，NIH和其他资金以及领导角色以及指导患者临床营养研究的良好记录。他的K24赠款的更新将提供受保护的时间和资源，以使申请人能够继续在该领域增加其多学科训练者的干部，并进一步发展营养代谢组学的新型研究领域，作为生物标志物发现，营养评估和结果预测的工具。