Patient Oriented Research In Clinical Nutrition

以患者为中心的临床营养研究

基本信息

批准号：
9103104
负责人：
Thomas R Ziegler
金额：
$ 17.75万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-16 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9103104
关键词：
Area Bioinformatics Clinical Clinical Investigator Clinical Nutrition Clinical Research Clinical Sciences Critical Care Critical Illness Cystic Fibrosis Development Diet Dietary Intervention Discipline Discipline of Nursing Doctor of Philosophy Dose Faculty Female Foundations Funding Funding Applicant Generations Glutamine Goals Grant Health Sciences Industry Institutes International Journals Junior Physician Leadership Link Medical Medical Students Medicine Mentors Metabolic Metabolism Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minority Groups Molecular Nutrition Assessment Nutritional Nutritional Science Nutritional Study Operative Surgical Procedures Oxidation-Reduction Patients Pediatrics Physicians Plasma Postdoctoral Fellow Productivity Publications Pulmonary Tuberculosis Recording of previous events Research Research Activity Research Design Research Institute Research Personnel Research Training Resources Role Sampling Services Short Bowel Syndrome Sickle Cell Anemia Societies Source Specialist Study Section TNFSF15 gene Therapeutic Time Training Training and Education Translational Research United States National Institutes of Health Vitamin D Wages Western Asia Georgia biomarker discovery career development editorial education research ethnic minority population global health graduate student innovation investigator training member metabolomics multidisciplinary novel nutrition outcome prediction patient oriented patient oriented research patient population post-doctoral training pre-doctoral programs senior faculty skills tool undergraduate student

项目摘要

DESCRIPTION (provided by applicant): This competing renewal application for the Midcareer Investigator Award in Patient Oriented Research (K24) "Patient-Oriented Research in Clinical Nutrition" seeks support for an accomplished physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. remains highly committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring undergraduates, graduate and medical students, postdoctoral fellows, clinical residents, and junior faculty in clinical nutrition research to continue to develop a needed new cadre of well-trained investigators in Clinical Nutrition. Renewal of this proposal will provide protected time t enable the P.I. to continue to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources in state-of-the-art metabolomics methods that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He maintains a strong and growing publication record, renewed independent funding for POR from NIH and other sources, a continued history of leadership roles in national nutrition- related societies, and increasing service on the editorial boards of front-line nutrition-oriented research journals. At Emory, the P.I. serves in the leadership of the NIH-funded CTSA grant, the Atlanta Clinical and Translational Science Institute (ACTSI), including as Co-Program Director of the ACTSI Research Education, Training and Career Development (RETCD) program, Co-Program Director of the ACTSI/RETCD KL2 postdoctoral training grant, and Program Director of the ACTSI/RETCD TL1 predoctoral training grant (TL1 RR025010). He serves in leadership roles with the Center for Clinical and Molecular Nutrition, several T32 training grants and the Emory graduate program in Nutrition and Health Science - all of which provide opportunities for continued mentoring in POR. Since the initial funding of this K24 grant (07/01/07), the P.I. has mentored the clinical/translational research activities of 32 trainees, from the level of undergraduate student to junior faculty, including a current cadre of 3 physician junior faculty members from the Emory Departments of Medicine and Pediatrics, respectively; 2 Ph.D. junior faculty investigators; 4 international physician investigators from the former Soviet Republic of Georgia; 3 physician postdoctoral fellows; 4 Ph.D.-trained postdoctoral fellows; a Pharm.D. specialist in clinical nutrition support; 3 Emory Ph.D. graduate students (2 in Nutrition and Health Sciences and 1 in Nursing) and an Emory undergraduate student. The candidate's POR program provides a rich training substrate for current and potential mentees and includes ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis.

描述（由申请人提供）：这项竞争性续签申请在以患者为导向的研究中的中级研究员奖（K24）“以患者为导向的临床营养研究”寻求支持为有成就的医师营养专家的支持，并在临床和翻译营养科学领域建立了研究者。 P.I.仍然致力于进行以患者为导向的研究（POR），专注于营养，并指导本科生，研究生和医学生，博士后研究员，临床居民以及临床营养研究的初级教师，以继续开发一项所需的新的在临床营养中经过良好学位的研究人员。该提案的续订将提供受保护的时间t使P.I.继续推进他的研究和指导营养方面的研究，并提供最先进的代谢组学方法的额外培训和资源，从而增强了他指导医生和其他临床研究人员的能力在与营养有关的研究中。申请人在营养和医学方面具有独特的培训背景，并为他的研究人员发起的POR和转化研究提供了联邦，基金会和行业资金的良好记录。他保持了强劲而不断增长的出版记录，从NIH和其他来源为POR恢复了独立资金，在国家营养相关社会中的领导角色持续历史，以及在面向前线营养的研究期刊的编辑委员会上的服务不断增加。在埃默里（Emory）在NIH资助的CTSA Grant，Atlanta临床和翻译科学研究所（ACTSI）的领导下，包括作为ACTSI研究教育，培训和职业发展（RETCD）计划的共同编程总监，ACTSI/RETCD KL2 KL2 KL2 KL2 KL2 KL2 KL2 COSTORAL培训培训总监ACTSI/RETCSI/RETCD TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 TL1 RR025010）。他曾在临床和分子营养中心，几项T32培训补助金以及埃默里营养与健康科学研究生计划中担任领导职务 - 所有这些都为继续在POR提供指导提供了机会。自此K24 Grant（07/01/07）的最初资金以来，P.I。从本科生到初级教师，包括32名学员的临床/转化研究活动，包括分别来自埃默里医学和儿科部门的3名医师初级教师的目前干部； 2博士初级教师调查员； 4来自佐治亚州前苏联共和国的国际医师调查员； 3个医师博士后研究员； 4博士学位训练的博士后研究员； Pharm.D。临床营养支持专家； 3 Emory Ph.D.研究生（营养和健康科学领域2名，护理中有1个）和一名埃默里大学生。候选人的POR计划为当前和潜在的受训者提供了丰富的训练底物，包括对谷氨酰胺在分解代谢状态的疗效和代谢影响的研究，包括重症监护，短肠综合征，囊性纤维化。镰状细胞贫血，与饮食相关的氧化还原控制和代谢组学分析。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ethanol Lock Therapy Markedly Reduces Catheter-Related Blood Stream Infections in Adults Requiring Home Parenteral Nutrition: A Retrospective Study From a Tertiary Medical Center.

乙醇封管疗法可显着减少需要家庭肠外营养的成人的导管相关血流感染：来自三级医疗中心的回顾性研究。

DOI：
10.1002/jpen.1698
发表时间：
2020
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
0
作者：
Gundogan,Kursat;Dave,NishaJ;Griffith,DanielP;Zhao,VivianM;McNally,ThereseA;Easley,KirkA;Haack,CarlaI;Galloway,JohnR;Ziegler,ThomasR
通讯作者：
Ziegler,ThomasR

Outcomes of percutaneous endoscopic gastrostomy in hospitalized patients at a tertiary care center in Turkey.

DOI：
10.1038/ejcn.2014.11
发表时间：
2014-04
期刊：
European journal of clinical nutrition
影响因子：
4.7
作者：
通讯作者：

Use of Reticulocyte Hemoglobin Content in the Assessment of Iron Deficiency in Children With Inflammatory Bowel Disease.

DOI：
10.1097/mpg.0000000000001335
发表时间：
2017-05
期刊：
Journal of pediatric gastroenterology and nutrition
影响因子：
2.9
作者：
Syed S;Kugathasan S;Kumar A;Prince J;Schoen BT;McCracken C;Ziegler TR;Suchdev PS
通讯作者：
Suchdev PS

Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation.