Core 1: Diabetes, GI & Nutrition, Ziegler

核心 1：糖尿病、胃肠道

• 批准号: 10260485
• 负责人: Thomas R Ziegler
• 金额: $ 17.8万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260485
• 关键词: Address; Adult; Adverse event; Affect; Area; Beta Cell; Biological; Biological Assay; Blood; Body Composition; Body fat; Caring; Cell physiology; Child; Childhood; Chronic; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Collaborations; Communities; Consultations; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Data Analyses; Diabetes Mellitus; Diagnostic; Diagnostic Procedure; Doctor of Philosophy; Early Diagnosis; Endocrine; Energy Metabolism; Faculty; Future; Gastrointestinal Diseases; Glucose Intolerance; Goals; Health; Hepatic; Image; Impairment; Individual; Interdisciplinary Study; Knowledge; Leadership; Link; Liver; Liver diseases; Longevity; Lung diseases; Maintenance; Measurement; Metabolism; Micronutrients; Mission; Modality; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Nutritional; Nutritional status; OGTT; Outcome; Persons; Phenotype; Play; Proteins; Quality of life; Reproductive Health; Research; Research Design; Research Personnel; Research Priority; Research Support; Research Training; Resources; Role; Sampling; Scientist; Services; Specimen; Technology; Teenagers; Testing; Tissues; Training; Training and Education; Translational Research; Translations; Universities; Visit; Withdrawal; base; bone; clinical data warehouse; cohort; comorbidity; cystic fibrosis patients; cystic fibrosis related diabetes; data repository; data warehouse; effective therapy; experience; gastrointestinal; graduate student; insulin sensitivity; interest; microbiome; novel; nutrient absorption; nutrition; outreach; sex; side effect; tool; training opportunity; translational scientist; undergraduate student

PROJECT SUMMARY – Core 1: Diabetes, GI, and Nutrition Core Major advances in the management of pulmonary disease in cystic fibrosis (CF) have led to a needed redirection of research to non-pulmonary comorbidities. Critical knowledge gaps exist in three key areas: 1) chronic endocrine complications, including CF-related diabetes (CFRD); 2) gastrointestinal (GI) and hepatic manifestations, including CF-related liver disease (CFLD); and 3) assessment and optimization of nutritional status. Individuals living with CF commonly experience comorbidities in one or more of these domains that significantly impair their overall quality of life and can reduce their long-term survival. In addition, little research has yet been conducted relevant to endocrine, GI, or nutritional issues in CF patients receiving CFTR modulators. The major goal of the Diabetes, GI, and Nutrition (DGN) Core of the Georgia CF Research and Translation Core Center (Georgia CF Core Center) is to support the research and training of clinical and translational scientists in non-pulmonary, NIDDK mission-related research in children and adults with CF. The DGN Core will consist of three integrated Sub-Cores, each providing unique and complementary faculty expertise and resources. These are: 1) Diabetes/Endocrine Sub-Core, 2) GI/Liver Sub-Core, and 3) Nutrition Sub-Core. The nature of the research supported by the DGN Sub-Cores is conducive to integrative interactions between each Sub-Core and with all other activities in our proposed Georgia CF Core Center. Each DGN Sub-Core will provide novel serial data obtained from annual research oral glucose tolerance test visits in children and adults with CF to the Georgia CF Data Warehouse, a state-wide data repository proposed by the Clinical Research and Informatics Core. We hypothesize that the DGN Core will lead to: 1) more impactful CF research; 2) more investigators new to CF performing multi-disciplinary research; 3) new collaborations linking DGN Core leadership and users to internal and external CF investigators; and 4) earlier detection, better diagnostics, and better treatment of CF comorbidities. We propose four specific aims to meet the goals of the DGN Core: Specific Aim 1: To provide a novel platform for established and new CF investigators wanting to incorporate diabetes, bone, sex/reproductive health, and other endocrine endpoints into their research (Diabetes/Endocrine Sub-Core). Specific Aim 2: To aid CF investigators interested in CF GI/liver disease with access to state-of-the-art tools and measurements, study design guidance, and data interpretation services (GI/Liver Sub-Core). Specific Aim 3: To provide scientists performing CF research with access to state-of-the-art tools and measurements, study design guidance, and data interpretation services related to nutrition and body composition outcomes (Nutrition Sub-Core). Specific Aim 4: To provide education, training and critical new outreach to promote interest and maximize DGN Core usage for clinical and translational research in CF across the lifespan.

项目摘要 - 核心1：糖尿病，GI和营养核心 囊性纤维化（CF）管理肺部疾病治疗的重大进展已导致需要重定向 非肺合并症的研究。关键知识差距存在三个关键领域：1）慢性 内分泌并发症，包括与CF相关的糖尿病（CFRD）； 2）胃肠道（GI）和肝 表现，包括与CF相关的肝病（CFLD）； 3）营养评估和优化 地位。具有CF共同经验的个人合并症 大大损害其整体生活质量，并可以减少其长期生存。此外，很少的研究 尚未与接收CFTR调节剂的CF患者中的内分泌，GI或营养问题有关。 佐治亚州CF研究和翻译核心的糖尿病，GI和营养（DGN）核心的主要目标 中心（佐治亚州CF核心中心）是为了支持临床和翻译科学家的研究和培训 CF的儿童和成人的非肺，NIDDK任务相关的研究。 DGN核心将包括 三个集成子核，每个核心提供独特而完整的教师专业知识和资源。这些 为：1）糖尿病/内分泌子核，2）GI/肝脏子核和3）营养子核。的本质 DGN子核支持的研究是针对每个子核和 在我们拟议的佐治亚州CF核心中心中，所有其他活动。每个DGN子核将提供新颖的串行 从年度研究的儿童和成人对佐治亚州的儿童和成人进行口服葡萄糖耐量测试访问获得的数据 CF Data Warehouse是临床研究和信息学核心提出的全州数据存储库。我们 假设DGN核心将导致：1）更具影响力的CF研究； 2）更多新的调查员 进行多学科研究； 3）将DGN核心领导和用户与内部用户联系起来的新合作 和外部CF调查人员； 4）早期检测，更好的诊断和更好的CF治疗 合并症。我们提出了四个具体目标，以实现DGN核心的目标： 特定目的1：为已建立和新的CF调查人员提供新颖的平台，希望合并 糖尿病，骨骼，性别/生殖健康和其他内分泌终点（糖尿病/内分泌） 子核）。 特定目的2：帮助对CF GI/肝脏疾病感兴趣的CF调查人员使用最先进的工具 以及测量，研究设计指南和数据解释服务（GI/肝脏子核）。 特定目的3：为科学家提供CF研究，并使用最先进的工具和 与营养和身体成分有关的测量，研究设计指导以及数据解释服务 结果（营养子核）。 特定目标4：提供教育，培训和关键的新外展活动以促进兴趣和最大的DGN 整个生命周期中CF的临床和翻译研究的核心用法。