University of Wisconsin Prostate SPORE

威斯康星大学前列腺孢子

基本信息

批准号：
10555398
负责人：
DAVID F. JARRARD
金额：
$ 206.11万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555398
关键词：
3-Dimensional Ablation Address Adjuvant Study Advanced Malignant Neoplasm Androgen Receptor Androgens Area Basic Science Bioinformatics Biological Biomedical Engineering Biometry Cancer Patient Castration Cessation of life Clinical Clinical Trials Combined Vaccines Data Development Disease Disease Progression Environment Feasibility Studies Generations Goals Human Image Immune response Immunology Immunotherapy Individual Institution Knowledge Lesion Link Local Therapy Malignant Neoplasms Malignant neoplasm of prostate Maps Medical Oncologist Metastatic Prostate Cancer Modeling Molds Morbidity - disease rate Neoadjuvant Therapy Outcome Pathology Patient-Focused Outcomes Patients Phase I Clinical Trials Positron-Emission Tomography Preclinical Testing Prostate Prostatectomy Quality of life Radiation Oncologist Radiology Specialty Research Research Personnel Research Project Grants Research Proposals Research Support Resistance Resources Scientist Signal Transduction Source Specimen Surgical Oncologist Therapeutic Time Tissues Translating Translational Research Treatment outcome Universities Wisconsin abiraterone advanced prostate cancer androgen deprivation therapy anticancer research biochip cancer therapy career castration resistant prostate cancer clinical care deprivation diagnostic strategy docetaxel high risk immune checkpoint blockade immunomodulatory therapies improved improved outcome inhibitor men molecular imaging mortality multidisciplinary next generation novel novel diagnostics novel strategies patient response pharmacologic phase I trial potential biomarker programs prostate cancer risk receptor vaccine response success therapeutic target therapy resistant translational goal treatment response treatment strategy tumor tumor heterogeneity tumor microenvironment vaccine evaluation

3-Dimensional Ablation Address Adjuvant Study Advanced Malignant Neoplasm Androgen Receptor Androgens Area Basic Science Bioinformatics Biological Biomedical Engineering Biometry Cancer Patient Castration Cessation of life Clinical Clinical Trials Combined Vaccines Data Development Disease Disease Progression Environment Feasibility Studies Generations Goals Human Image Immune response Immunology Immunotherapy Individual Institution Knowledge Lesion Link Local Therapy Malignant Neoplasms Malignant neoplasm of prostate Maps Medical Oncologist Metastatic Prostate Cancer Modeling Molds Morbidity - disease rate Neoadjuvant Therapy Outcome Pathology Patient-Focused Outcomes Patients Phase I Clinical Trials Positron-Emission Tomography Preclinical Testing Prostate Prostatectomy Quality of life Radiation Oncologist Radiology Specialty Research Research Personnel Research Project Grants Research Proposals Research Support Resistance Resources Scientist Signal Transduction Source Specimen Surgical Oncologist Therapeutic Time Tissues Translating Translational Research Treatment outcome Universities Wisconsin abiraterone advanced prostate cancer androgen deprivation therapy anticancer research biochip cancer therapy career castration resistant prostate cancer clinical care deprivation diagnostic strategy docetaxel high risk immune checkpoint blockade immunomodulatory therapies improved improved outcome inhibitor men molecular imaging mortality multidisciplinary next generation novel novel diagnostics novel strategies patient response pharmacologic phase I trial potential biomarker programs prostate cancer risk receptor vaccine response success therapeutic target therapy resistant translational goal treatment response treatment strategy tumor tumor heterogeneity tumor microenvironment vaccine evaluation

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项目摘要

PROJECT SUMMARY The University of Wisconsin (UW) Prostate Cancer SPORE is a highly collaborative research proposal that links basic scientists with prostate cancer clinicians to advance treatment strategies for prostate cancer patients. The broad objectives of this SPORE are to: 1) Increase multidisciplinary translational research and develop the next generation of prostate cancer researchers, 2) Develop common resources to promote advances, 3) Translate promising new approaches into patients, and 4) Improve overall survival and quality of life for patients with prostate cancer. A crosscutting theme that encompasses this SPORE is understanding tumor resistance in advanced prostate cancer and exploiting this knowledge to improve patient outcomes. The UW Prostate Cancer SPORE has three primary research projects: 1) Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer, 2) Androgen Deprivation as an Immune Modulating Therapy in Combination with Targeted Immunotherapy of Prostate Cancer, and 3) Extending Clinical Benefit by Selective Treatment of Resistant Lesions in mCRPC. The SPORE will support this research with three Cores (Administrative, Integrated Pathology Radiology, and Biostatistics and Bioinformatics). The Career Enhancement Program and Developmental Research Program will engage new and established investigators and further translational goals in a rich multidisciplinary environment. When completed, the research of the UW Prostate Cancer SPORE will advance our treatments and understanding of prostate cancer and undoubtedly beneficially impact patients with this disease.

项目摘要威斯康星大学（UW）前列腺癌孢子是一项高度协作的研究建议，可以联系前列腺癌临床医生的基础科学家可以推进前列腺癌患者的治疗策略。这该孢子的广泛目标是：1）增加多学科翻译研究并发展下一个前列腺癌研究人员的产生，2）开发共同资源以促进进步，3）翻译有希望进入患者的新方法，以及4）改善患者的总体生存和生活质量前列腺癌。一个包含该孢子的横切主题是了解肿瘤的抗性晚期前列腺癌并利用这些知识以改善患者的结果。 UW前列腺癌孢子有三个主要的研究项目：1）转移性级联的肿瘤微环境在高风险前列腺癌，2）雄激素剥夺是一种免疫调节疗法，结合针对前列腺癌的靶向免疫疗法，以及3）通过选择性治疗来扩大临床益处 MCRPC中的抗性病变。孢子将用三个核心支持这项研究（行政，整合病理放射学，生物统计学和生物信息学）。职业增强计划和发展研究计划将参与新的和既定的研究者并进一步的翻译目标在丰富的多学科环境中。完成后，UW前列腺癌孢子的研究将促进我们的治疗和对前列腺癌的理解，无疑会对患者产生这种疾病。