University of Wisconsin Prostate SPORE

威斯康星大学前列腺孢子

基本信息

批准号：
10555398
负责人：
DAVID F. JARRARD
金额：
$ 206.11万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555398
关键词：
3-Dimensional Ablation Address Adjuvant Study Advanced Malignant Neoplasm Androgen Receptor Androgens Area Basic Science Bioinformatics Biological Biomedical Engineering Biometry Cancer Patient Castration Cessation of life Clinical Clinical Trials Combined Vaccines Data Development Disease Disease Progression Environment Feasibility Studies Generations Goals Human Image Immune response Immunology Immunotherapy Individual Institution Knowledge Lesion Link Local Therapy Malignant Neoplasms Malignant neoplasm of prostate Maps Medical Oncologist Metastatic Prostate Cancer Modeling Molds Morbidity - disease rate Neoadjuvant Therapy Outcome Pathology Patient-Focused Outcomes Patients Phase I Clinical Trials Positron-Emission Tomography Preclinical Testing Prostate Prostatectomy Quality of life Radiation Oncologist Radiology Specialty Research Research Personnel Research Project Grants Research Proposals Research Support Resistance Resources Scientist Signal Transduction Source Specimen Surgical Oncologist Therapeutic Time Tissues Translating Translational Research Treatment outcome Universities Wisconsin abiraterone advanced prostate cancer androgen deprivation therapy anticancer research biochip cancer therapy career castration resistant prostate cancer clinical care deprivation diagnostic strategy docetaxel high risk immune checkpoint blockade immunomodulatory therapies improved improved outcome inhibitor men molecular imaging mortality multidisciplinary next generation novel novel diagnostics novel strategies patient response pharmacologic phase I trial potential biomarker programs prostate cancer risk receptor vaccine response success therapeutic target therapy resistant translational goal treatment response treatment strategy tumor tumor heterogeneity tumor microenvironment vaccine evaluation

项目摘要

PROJECT SUMMARY The University of Wisconsin (UW) Prostate Cancer SPORE is a highly collaborative research proposal that links basic scientists with prostate cancer clinicians to advance treatment strategies for prostate cancer patients. The broad objectives of this SPORE are to: 1) Increase multidisciplinary translational research and develop the next generation of prostate cancer researchers, 2) Develop common resources to promote advances, 3) Translate promising new approaches into patients, and 4) Improve overall survival and quality of life for patients with prostate cancer. A crosscutting theme that encompasses this SPORE is understanding tumor resistance in advanced prostate cancer and exploiting this knowledge to improve patient outcomes. The UW Prostate Cancer SPORE has three primary research projects: 1) Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer, 2) Androgen Deprivation as an Immune Modulating Therapy in Combination with Targeted Immunotherapy of Prostate Cancer, and 3) Extending Clinical Benefit by Selective Treatment of Resistant Lesions in mCRPC. The SPORE will support this research with three Cores (Administrative, Integrated Pathology Radiology, and Biostatistics and Bioinformatics). The Career Enhancement Program and Developmental Research Program will engage new and established investigators and further translational goals in a rich multidisciplinary environment. When completed, the research of the UW Prostate Cancer SPORE will advance our treatments and understanding of prostate cancer and undoubtedly beneficially impact patients with this disease.

项目概要威斯康星大学 (UW) 前列腺癌 SPORE 是一项高度协作的研究提案，它将基础科学家与前列腺癌临床医生共同推进前列腺癌患者的治疗策略。这该 SPORE 的主要目标是： 1) 增加多学科转化研究并开发下一代一代前列腺癌研究人员，2) 开发共同资源以促进进步，3) 翻译为患者提供有前途的新方法，以及 4) 提高患者的总体生存率和生活质量前列腺癌。包含该 SPORE 的一个横切主题是了解肿瘤的抵抗力晚期前列腺癌并利用这些知识来改善患者的治疗结果。华盛顿大学前列腺癌 SPORE 拥有三个主要研究项目：1）肿瘤微环境中转移级联的启动子高风险前列腺癌，2) 雄激素剥夺作为免疫调节疗法与前列腺癌的靶向免疫治疗，以及 3) 通过选择性治疗扩大临床获益 mCRPC 中的耐药病变。 SPORE 将通过三个核心（行政、综合病理学放射学、生物统计学和生物信息学）。职业提升计划和发展研究计划将吸引新的和已建立的研究人员以及进一步的转化目标在丰富的多学科环境中。威斯康星大学前列腺癌 SPORE 的研究完成后，将推进我们对前列腺癌的治疗和了解，无疑对患有前列腺癌的患者产生有益的影响这种病。