TRANSLATIONAL RESEARCH IN LUNG BIOLOGY AND DISEASE

肺生物学和疾病的转化研究

基本信息

批准号：
8364916
负责人：
Charles G Irvin
金额：
$ 112.55万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8364916
关键词：
Address Age Animals Applications Grants Asthma Biology Cause of Death Cellular biology Centers of Research Excellence Cessation of life Clinical Research Clinical Trials Consultations Cystic Fibrosis Development Diagnosis Disease Doctor of Philosophy Environment Epithelial Cells Extramural Activities Funding Gap Junctions Goals Grant Interdisciplinary Study Lung Lung Inflammation Lung diseases Medicine Mentors Methods Molecular Morbidity - disease rate National Center for Research Resources Pathogenesis Peer Review Phase Phenotype Physiology Principal Investigator Productivity Publications Research Research Infrastructure Research Personnel Research Support Resources Science of genetics Scientist Societies Source Training Transgenic Organisms Translational Research United States United States National Institutes of Health Universities Vermont career career development college cost knockout animal mortality programs public health relevance research and development success

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle e we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on competitive scientific approaches 3) Maintain a "cutting edge" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy. PUBLIC HEALTH RELEVANCE (provided by applicant): Lung disease represents a huge burden on society in terms of death and disease. The purpose of this proposal is to further the development of the Vermont Lung Center that supports research into lung biology and disease.

该副本是利用资源的众多研究子项目之一由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持而且，副投影的主要研究员可能是其他来源提供的包括其他NIH来源。列出的总费用可能代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。描述（由申请人提供）：肺部疾病是美国发病率和死亡率的重要原因。尽管所有其他主要的死亡原因正在减少，但由于肺部疾病而导致的年龄调整后的死亡率持续增加。这项第三阶段更新应用的总体目的是继续在佛蒙特大学医学院佛蒙特州肺中心（VLC）开发肺部生物学和疾病研究计划。 VLC计划的基石是卓越。科学强度包括气道上皮细胞生物学，囊性纤维化，哮喘炎症，肺部生理学，转化动物研究以及对肺部疾病发病机理的临床研究。在最后一个资金周期E中，我们继续积累了生产力的记录，包括：招募良好的培训良好的博士学位和MD肺科学家，高影响力同行评审的出版物以及持续的以及持续的校外资金增加。佛蒙特州肺中心持续成功的一个关键要求是刺激的环境，可以在其中发生最佳的职业发展。因此，VLC-Cobre的当前目标是：1）发展一组才华横溢的MD和PhD生物医学研究者的职业2）对竞争性科学方法提供熟练的指导和咨询3）维持“最先进将创建应用程序。该建议还解决了UVM上扩展和支持翻译多学科研究的迫切需求，因为这就是基本分子，细胞和遗传科学的进步如何转化为诊断和治疗的新方法。公共卫生相关性（由申请人提供）：在死亡和疾病方面，肺病代表了社会的巨大负担。该提案的目的是进一步发展佛蒙特州肺中心的发展，该中心支持研究肺部生物学和疾病的研究。