Translational Research in Lung Biology and Disease

肺生物学和疾病的转化研究

• 批准号: 8723247
• 负责人: Charles G Irvin
• 金额: $ 109.31万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723247
• 关键词: Address; Age; Animals; Applications Grants; Asthma; Biology; Cause of Death; Cellular biology; Centers of Research Excellence; Cessation of life; Clinical Research; Clinical Trials; Consultations; Cystic Fibrosis; Development; Diagnosis; Disease; Doctor of Philosophy; Environment; Epithelial Cells; Extramural Activities; Funding; Gap Junctions; Goals; Interdisciplinary Study; Lung; Lung Inflammation; Lung diseases; Medicine; Mentors; Methods; Molecular; Morbidity - disease rate; Pathogenesis; Peer Review; Phase; Phenotype; Physiology; Productivity; Publications; Research; Research Personnel; Research Support; Science of genetics; Scientist; Societies; Training; Transgenic Organisms; Translational Research; United States; Universities; Vermont; career; career development; college; knockout animal; mortality; programs; research and development; success

Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on com petitive scientific approaches 3) Maintain a "cutting edge" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy.

肺部疾病是美国发病率和死亡率的一个重要原因。尽管所有其他主要死因都在下降，但肺病导致的年龄调整死亡率却持续上升。 COBRE III 期续展申请的总体目的是继续开发佛蒙特大学医学院佛蒙特肺中心 (VLC) 的肺生物学和疾病研究项目。 VLC 计划的基石是卓越。科学优势包括气道上皮细胞生物学、囊性纤维化、哮喘炎症、肺部生理学、转化动物研究以及肺部疾病发病机制的临床研究。在上一个资助周期中，我们继续积累了生产力记录，包括：招募了足够数量的训练有素的博士和医学博士肺科科学家、高影响力的同行评审出版物以及持续大幅增加的外部资助。 佛蒙特州肺脏中心持续成功的一个关键要求是能够实现最佳职业发展的激励环境。因此，VLC-COBRE 当前的目标是： 1）培养一批才华横溢的MD和PhD生物医学研究者的职业生涯 2）提供有竞争力的科学方法的熟练指导和咨询 3）保持“前沿”的研究环境 4) 开发临床研究核心，维护转基因/基因敲除动物和小动物表型核心， 该拟议计划将通过与哪个中心建立联系来实现 VLC 的可持续性 将创建拨款申请。该提案还解决了扩大和支持的迫切需要 UVM 的转化性多学科研究，因为这就是基础分子、细胞的进步的方式 和遗传科学转化为新的诊断和治疗方法。