Translational Research in Lung Biology and Disease

肺生物学和疾病的转化研究

• 批准号: 8319673
• 负责人: Charles G Irvin
• 金额: $ 113.1万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319673
• 关键词: Address; Age; Animals; Applications Grants; Asthma; Biology; Cause of Death; Cellular biology; Centers of Research Excellence; Cessation of life; Clinical Research; Clinical Trials; Consultations; Cystic Fibrosis; Development; Diagnosis; Disease; Doctor of Philosophy; Environment; Epithelial Cells; Extramural Activities; Funding; Gap Junctions; Goals; Interdisciplinary Study; Lung; Lung Inflammation; Lung diseases; Medicine; Mentors; Methods; Molecular; Morbidity - disease rate; Pathogenesis; Peer Review; Phase; Phenotype; Physiology; Productivity; Publications; Research; Research Personnel; Research Support; Science of genetics; Scientist; Societies; Training; Transgenic Organisms; Translational Research; United States; Universities; Vermont; career; career development; college; knockout animal; mortality; programs; research and development; success

Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on com petitive scientific approaches 3) Maintain a "cutting edge" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy.

肺部疾病是美国发病率和死亡率的重要原因。尽管所有其他主要的死亡原因正在减少，但由于肺部疾病而导致的年龄调整后的死亡率持续增加。这项第三阶段更新应用的总体目的是继续在佛蒙特大学医学院佛蒙特州肺中心（VLC）开发肺部生物学和疾病研究计划。 VLC计划的基石是卓越。科学强度包括气道上皮细胞生物学，囊性纤维化，哮喘炎症，肺部生理学，转化动物研究以及对肺部疾病发病机理的临床研究。在最后一个融资周期中，我们继续积累了生产力的记录，包括：招募大量训练有素的博士学位和MD肺科学家，高影响力同行评审的出版物以及继续增加的校外资金。 佛蒙特州肺中心持续成功的一个关键要求是刺激的环境，可以在其中发生最佳的职业发展。因此，VLC-Cobre的当前目标是： 1）发展一群才华横溢的MD和博士生物医学研究人员的职业 2）就COM PETIVE科学方法提供熟练的指导和咨询 3）保持“最前沿”研究环境 4）发展临床研究核心，维持转基因/敲除动物和小动物表型核心， 该提议的计划将通过形成从哪个中心的Nexus来朝着VLC的可持续性发展 将创建赠款申请。该建议还解决了扩展和支持的迫切需求 UVM的翻译多学科研究，因为这是基本分子，细胞的进步 遗传学科学被转化为新的诊断和治疗方法。