INHALATION EXPOSURE FACILITY

吸入暴露设施

• 批准号: 7715574
• 负责人: CHARLES George PLOPPER
• 金额: $ 5.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715574
• 关键词: Adult; Aerosols; Air Pollutants; Air Pollution; Airway Resistance; Alabama; Allergens; Animal Housing; Animals; Antibodies; Aromatic Polycyclic Hydrocarbons; Asthma; Breathing; Bronchoscopes; Chemical Industry; Computer Retrieval of Information on Scientific Projects Database; Cultured Cells; Development; Equipment; Exposure to; Funding; Gases; Generations; Grant; Health; Human; In Vitro; Indirect Calorimetry; Infant; Inhalation Exposure; Institutes; Institution; Laboratories; Louisiana; Lung; Macaca mulatta; Measurement; Mechanics; Medical Research; Metabolic; Michigan; Monitor; Monkeys; Pacific Northwest; Pennsylvania; Phase; Provider; Pulmonary function tests; Range; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Respiratory System; Scientist; Services; Solutions; Source; Suspension substance; Suspensions; System; Testing; Therapeutic Agents; Toxicology; United States Environmental Protection Agency; United States National Institutes of Health; Universities; air filter; comparative; follower of religion Jewish; in vivo; injury and repair; medical schools; nonhuman primate; ozone exposure; planetary Atmosphere; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. A relatively recent addition to the capabilities is a pulmonary function laboratory that offers a comprehensive array of testing for infant through adult nonhuman primates. Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + ETS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing This facility continued to provide stable, well characterized exposures to air pollutants, allergens, therapeutic agents, aerosols and other test atmospheres as required by the research projects supported. As a Core service provider, the facility supported 13 research projects during the reporting period with some 34 major investigators. In addition to UC Davis investigators, core services were provided to scientists at University of Alabama at Birmingham, Michigan State University, Pennsylvania State University, Louisiana State University, Chemical Industry Institute of Toxicology, U.S. EPA, Pacific Northwest National Laboratory, National Jewish Medical and Research Center, UCSF School of Medicine, Innate Pharma and Genentech, Inc. Major emphasis in research activities was directed to further inhalation exposure studies of asthma and air pollution in nonhuman primates. New modular building animal housing supplied with filtered air was tested and put into routine use. Equipment was obtained for microspray delivery of solutions and suspensions, and particularly antibodies, through a bronchoscope to rhesus macaques. Other nonhuman primate projects included continuing metabolic measurements using indirect calorimetry. A new system is under development for the generation of combustion products including polycyclic aromatic hydrocarbons for inhalation chamber studies.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目标：位于 CNPRC 的吸入暴露设施是大学校园内最大的吸入暴露设施之一。 它提供了利用非人类灵长类动物进行独特的人类健康相关肺部研究的机会。 存在体内或体外暴露于精确表征和受控的气体和气溶胶气氛的能力。 对于空气污染研究的健康影响，用于暴露研究的测试对象范围可以包括动物、分离和灌注的肺、气管外植体以及人或猴肺细胞培养物。 这允许采用综合的、比较的方法来定义呼吸系统损伤和修复的机制。 最近增加的功能是肺功能实验室，为婴儿到成年非人类灵长类动物提供全面的测试。 提供的服务： + 特别曝光 + 臭氧产生和监测 + 气溶胶生成和分析 + 氮氧化物的产生和监测 + 过敏原生成和分析 + 暴露在过滤空气中 + ETS 生成和分析 肺功能检测实验室 + 基线气道阻力测试 + 气道反应性测试 + 过敏原反应性测试 + 静态肺力学测试 + 后期过敏原反应性测试 该设施继续按照所支持的研究项目的要求提供稳定、特征明确的空气污染物、过敏原、治疗剂、气溶胶和其他测试气氛的暴露。 作为核心服务提供商，该机构在报告期内支持了 13 个研究项目，约有 34 名主要研究人员。 除了加州大学戴维斯分校的研究人员之外，还为阿拉巴马大学伯明翰分校、密歇根州立大学、宾夕法尼亚州立大学、路易斯安那州立大学、化学工业毒理学研究所、美国环保署、太平洋西北国家实验室、国家犹太医学和医学中心的科学家提供了核心服务。加州大学旧金山分校医学院研究中心、Innate Pharma 和 Genentech, Inc. 研究活动的主要重点是进一步研究非人类灵长类动物的哮喘和空气污染的吸入暴露。 配备过滤空气的新型模块化动物房屋经过测试并投入日常使用。 获得了通过支气管镜向恒河猴微喷雾输送溶液和悬浮液，特别是抗体的设备。 其他非人类灵长类动物项目包括使用间接量热法进行持续代谢测量。 正在开发一种新系统，用于生成燃烧产物，包括用于吸入室研究的多环芳烃。