Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are Smoked

吸电子烟的家庭中的空气质量、儿童和成人健康

基本信息

批准号：
9412238
负责人：
Terry Gordon
金额：
$ 50.16万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9412238
关键词：
Acute Adolescent Adopted Adoption Adult Aerosols Air Air Pollutants Area Biological Markers Blood Blood Pressure CD40 Ligand Carbon Monoxide Cardiopulmonary Cardiovascular Diseases Cardiovascular Physiology Chemicals Child Chronic Chronic Disease Cigarette Clinical Community Health Consumption Dangerousness Electronic cigarette Environmental Tobacco Smoke Epithelial Cells Exposure to Fibrinogen Flavoring Fright Future Glycerol Hand Harm Reduction Health Heating Home environment Household Individual Lead Lung diseases Mainstreaming Morbidity - disease rate Nasal cavity Nicotine Oral cavity P-Selectin Particulate Matter Physiological Poison Propylene Glycols Public Health Research Research Design Risk Risk Factors Smoke Smoker Source Spirometry System Testing Time Tobacco Tobacco smoking Tobacco use Trace Elements Vascular Cell Adhesion Molecule-1 cardiovascular disorder risk cigarette smoking cigarette smoking heart rate variability indexing intercellular cell adhesion molecule mortality non-smoking policy implication pollutant pulmonary function smoking cessation tobacco exposure transcriptomics vaping

项目摘要

Abstract Electronic cigarettes (e-cigs), were introduced to the US market only 10 years ago, and are markedly different from traditional cigarettes. Traditional cigarettes contain tobacco and are smoked through combustion, thereby exposing the smoker and those nearby (secondhand smoke; SHS) to thousands of potentially dangerous tobacco and combustion-related agents. In contrast, E-cigs are “vaped” rather than smoked, and the resultant aerosols produced contain a far smaller number of potentially toxic chemicals, such as nicotine and flavorings, as well as byproducts caused by the heating of propylene glycol, and glycerin. Thus, they are widely believed and marketed as a safer alternative to cigarette smoking, yet the actual dangers posed by the use of these e- cigarettes remains largely unexplored. Many see the widespread adoption of this alternative nicotine delivery system as holding great promise in helping people quit or reduce cigarette use, and thus are seen as having profoundly positive effects as harm reduction agents. Others fear that their use may lead adolescents (the group most likely to begin using cigarettes) to transition from their use to the use of cigarettes. To date, missing from this debate is the potential biologic harm of mainstream and secondhand e-cig aerosols in homes where these agents are used, and how such exposure compares to mainstream and SHS from cigarettes. Our overall hypothesis is that e-cig vaping in homes leads to exposure to aerosols containing a number of pollutants and that this exposure is associated with decrements in cardiopulmonary function and increases in biomarkers for risk of future pulmonary and cardiovascular disease both in the e-cig vaper and non-smoking/non-vaping children and adults in such homes. Findings from this study will have very significant research and public health implications by enhancing understanding of the potential dangers of e-cigs, which are rapidly increasing in use and which many believe is a safe alternative to cigarette smoking and an aid to helping tobacco smoking cessation.

抽象的电子烟（电子烟）仅在10年前才引入美国市场，并且明显不同传统的香烟。将吸烟者和附近的吸烟者（二手烟; SHS）暴露于数千个危险的危险中烟草和梳子相关的剂相比，电子烟是“蒸发”而不是烟熏产生的气溶胶包含较少数量的潜在有毒化学物质，例如尼古丁和调味剂，以及由丙烯甘油和甘油引起的副产品。并以更安全的吸烟方式销售，但是使用E-的实际危险香烟仍然没有探索。系统作为帮助人们戒烟或减少香烟的巨大承诺，因此被视为作为损害修订剂的深刻积极影响。最有可能开始使用香烟的小组从使用中过渡到使用香烟从这一辩论中，主流和二手电子烟气的潜在生物学危害是使用这些试剂，以及这种暴露与我们整体上的主流和SHS相比假设是，房屋中的电子烟蒸发导致向气溶胶爆炸，遏制污染物和这种暴露与心肺功能的降低有关，并增加了生物标志物的锻炼。在E-cig Vaper非吸烟/不蒸发中，未来肺和心血管疾病的风险在研究世界中的儿童和成年人中。通过增强对电子烟的潜在危险的理解来迅速增加的健康影响在使用中，许多人认为这是吸烟的安全替代品，也可以帮助吸烟停止。