IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE

新生屋尘螨敏感猴对臭氧的免疫反应

• 批准号: 7562144
• 负责人: CHARLES George PLOPPER
• 金额: $ 5.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562144
• 关键词: Adrenal Cortex Hormones; Aerosols; Animal Model; Asthma; Attenuated; Breathing; Child; Childhood Asthma; Computer Retrieval of Information on Scientific Projects Database; Development; Eosinophilia; Funding; Grant; Immune; Infant; Institution; Life; Macaca mulatta; Modality; Monkeys; Neonatal; Ozone; Pyroglyphidae; Reporting; Research; Research Personnel; Resources; Safety; Source; Treatment Efficacy; Treatment Protocols; United States National Institutes of Health; airway hyperresponsiveness; airway inflammation; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Inhaled corticosteroids (ICS) are frequently used to treat persistent asthma in young children, however the safety and efficacy of this therapeutic modality during the first year of life is not known. We have previously reported that an exposure regimen of house dust mite (HDM) aerosol and ozone results in the development of airway hyperresponsiveness and eosinophilia in 6 month old infant rhesus monkeys. In the current study, we determined if ICS treatment can prevent or attenuate airways inflammation in this animal model of childhood asthma.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 目的：吸入的皮质类固醇（IC）经常用于治疗幼儿的持续性哮喘，但是在生命的第一年，这种治疗方式的安全性和功效尚不清楚。我们以前已经报道说，房屋尘螨（HDM）气溶胶和臭氧的暴露方案导致了6个月大的婴儿恒河猴的气道高反应和嗜酸性粒细胞的发展。在当前的研究中，我们确定ICS治疗是否可以预防或减弱这种儿童哮喘动物模型中的气道炎症。