IMMUNE RESP IN NEONATAL HOUSE DUST MITE-SENSITIZED MONKEYS FOL EXPTO OZONE

新生屋尘螨敏感猴对臭氧的免疫反应

• 批准号: 8357240
• 负责人: DALLAS Melvin HYDE
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357240
• 关键词: Adrenal Cortex Hormones; Aerosols; Animal Model; Asthma; Attenuated; Breathing; California; Child; Childhood Asthma; Development; Eosinophilia; Funding; Grant; Immune; Infant; Life; Macaca mulatta; Modality; Monkeys; National Center for Research Resources; Neonatal; Ozone; Primates; Principal Investigator; Pyroglyphidae; Regimen; Reporting; Research; Research Infrastructure; Resources; Safety; Source; Treatment Efficacy; United States National Institutes of Health; airway hyperresponsiveness; airway inflammation; cost; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Inhaled corticosteroids (ICS) are frequently used to treat persistent asthma in young children, however the safety and efficacy of this therapeutic modality during the first year of life is not known. We have previously reported that an exposure regimen of house dust mite (HDM) aerosol and ozone results in the development of airway hyperresponsiveness and eosinophilia in 6 month old infant rhesus monkeys. In the current study, we determined if ICS treatment can prevent or attenuate airways inflammation in this animal model of childhood asthma.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 吸入皮质类固醇 (ICS) 经常用于治疗幼儿的持续性哮喘，但这种治疗方式在一岁以内的安全性和有效性尚不清楚。我们之前曾报道过，屋尘螨 (HDM) 气溶胶和臭氧的暴露方案会导致 6 个月大的恒河猴幼崽出现气道高反应性和嗜酸粒细胞增多症。在当前的研究中，我们确定了 ICS 治疗是否可以预防或减轻儿童哮喘动物模型中的气道炎症。