INHALATION EXPOSURE FACILITY

吸入暴露设施

• 批准号: 8357253
• 负责人: DALLAS Melvin HYDE
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357253
• 关键词: Adult; Aerosols; Air Pollution; Airway Resistance; Allergens; Animals; Blood capillaries; California; Cardiac Output; Cell Culture Techniques; Diffuse; Exposure to; Funding; Gases; Generations; Grant; Health; Human; In Vitro; Infant; Inhalation Exposure; Laboratories; Lung; Mechanics; Monitor; Monkeys; National Center for Research Resources; Phase; Primates; Principal Investigator; Pulmonary function tests; Research; Research Infrastructure; Resources; Respiratory System; Services; Source; Testing; United States National Institutes of Health; Universities; air filter; capillary; comparative; cost; in vivo; injury and repair; nonhuman primate; ozone exposure; planetary Atmosphere; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates.Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + DCS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing + Lung diffusing capacity, cardiac output and pulmonary capillary volume

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 CNPRC 的吸入暴露设施是大学校园内最大的吸入暴露设施之一。 它提供了利用非人类灵长类动物进行独特的人类健康相关肺部研究的机会。 存在体内或体外暴露于精确表征和受控的气体和气溶胶气氛的能力。 对于空气污染研究的健康影响，用于暴露研究的测试对象范围可以包括动物、分离和灌注的肺、气管外植体以及人或猴肺细胞培养物。 这允许采用综合的、比较的方法来定义呼吸系统损伤和修复的机制。 肺功能实验室为婴儿到成年非人类灵长类动物提供全面的测试。提供的服务： + 特别曝光 + 臭氧产生和监测 + 气溶胶生成和分析 + 氮氧化物的产生和监测 + 过敏原生成和分析 + 暴露在过滤空气中 + DCS 生成和分析 肺功能检测实验室 + 基线气道阻力测试 + 气道反应性测试 + 过敏原反应性测试 + 静态肺力学测试 + 后期过敏原反应性测试 + 肺弥散能力、心输出量和肺毛细血管容量