NEURAL MECHANISMS OF SOCIAL COGNITION AND BONDING

社会认知和联系的神经机制

• 批准号: 7715827
• 负责人: Larry J Young
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715827
• 关键词: Animal Model; Autistic Disorder; Brain; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Cycloserine; Data; Disruption; Drug Design; Funding; Glutamate Agonist; Glutamates; Goals; Grant; Institution; Learning; Mental disorders; Neurotransmitters; Object Attachment; Oxytocin; Pharmaceutical Preparations; Reporting; Research; Research Personnel; Resources; Signal Transduction; Source; System; United States National Institutes of Health; affiliative behavior; memory process; neuromechanism; prairie vole; social attachment; social cognition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we collected data demonstrating that the glutamate agonist, d-cycloserine facilitates social bond formation in prairie voles. D-cycloserine is a drug that has been used in clinical trials. Studies have/and are underway to determine if D-cycloserine and oxytocin act synergistically to enhance social cognition in prairie voles. These studies will have direct translational implications for designing drug treatments in autism. The goal of this project is to investigate the interaction of the neurotransmitters glutamate and oxytocin in social cognition and social bonding in prairie voles. Prairie voles are an ideal animal model for investigating the brain mechanisms that regulate affiliative behavior and social bonding. Previous studies have demonstrated that oxytocin facilitates social bonding in prairie voles. In addition, oxytocin modulates the glutamate system in prairie voles. Glutamate has been implicated in learning and memory processes. We hypothesize that enhance oxytocin and glutamate signaling in the brain may be an effective treatment for the disruption in social cognition in psychiatric disorders such as autism.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在报告期间，我们收集了数据，表明谷氨酸激动剂D-胞丝烯促进了草原田鼠的社会纽带形成。 D-胞丝烯是一种已在临床试验中使用的药物。 研究已经/并且正在进行中，以确定D-胞霉素和催产素是否在协同作用方面起作用，以增强草原田鼠的社会认知。 这些研究将对设计自闭症的药物治疗具有直接的翻译意义。 该项目的目的是研究神经递质谷氨酸和催产素在草原田鼠的社会认知和社会联系中的相互作用。 草原田鼠是研究调节隶属行为和社会联系的大脑机制的理想动物模型。 先前的研究表明，催产素促进了草原田鼠的社会联系。 此外，催产素在草原田鼠中调节谷氨酸系统。 谷氨酸与学习和记忆过程有关。 我们假设增强大脑中的催产素和谷氨酸信号传导可能是对自闭症等精神疾病中社会认知中断的有效治疗方法。